| Type |
Details |
Score |
| Gene |
| Type: |
gene |
| Organism: |
human |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
MURC (also known as cavin 4) is a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway []. It plays a role in hypoxia-induced hypertrophy in cardiomyocytes []. It is involved in membrane trafficking of caveolin-3 in cardiomyocytes []. Fish have two murc genes (murca and murcb) []. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Naito D |
| Year: |
2015 |
| Journal: |
Am J Physiol Heart Circ Physiol |
| Title: |
The coiled-coil domain of MURC/cavin-4 is involved in membrane trafficking of caveolin-3 in cardiomyocytes. |
| Volume: |
309 |
| Issue: |
12 |
| Pages: |
H2127-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ogata T |
| Year: |
2008 |
| Journal: |
Mol Cell Biol |
| Title: |
MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. |
| Volume: |
28 |
| Issue: |
10 |
| Pages: |
3424-36 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
362
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shyu KG |
| Year: |
2014 |
| Journal: |
Clin Sci (Lond) |
| Title: |
Hypoxia activates muscle-restricted coiled-coil protein (MURC) expression via transforming growth factor-β in cardiac myocytes. |
| Volume: |
126 |
| Issue: |
5 |
| Pages: |
367-75 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Housley MP |
| Year: |
2016 |
| Journal: |
PLoS Genet |
| Title: |
Cavin4b/Murcb Is Required for Skeletal Muscle Development and Function in Zebrafish. |
| Volume: |
12 |
| Issue: |
6 |
| Pages: |
e1006099 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus caroli |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus pahari |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
Mus spretus |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ogata T |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors. |
| Volume: |
111 |
| Issue: |
10 |
| Pages: |
3811-6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317451 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689428 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317452 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Brain |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317451 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317452 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Heart |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317451 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1860128 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317452 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Aorta |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317451 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3598828 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317452 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Skeletal muscle |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317451 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1702128 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317452 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Stomach |
| Detected: |
false |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317451 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1672828 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317452 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Lung |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317451 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1737328 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317452 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Kidney |
| Detected: |
false |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317451 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1684628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317452 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Liver |
| Detected: |
false |
| Specimen Num: |
8 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317451 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1876728 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317452 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Spleen |
| Detected: |
false |
| Specimen Num: |
9 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317451 |
| Assay Type: |
Northern blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Absent |
| Sex: |
Male |
| Emaps: |
EMAPS:1797228 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317452 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Testis |
| Detected: |
false |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317449 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610517 |
|
| Stage: |
TS17 |
| Assay Id: |
MGI:5317551 |
| Age: |
embryonic day 10.5 |
|
|
| Specimen Label: |
+ |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317449 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610517 |
|
| Stage: |
TS17 |
| Assay Id: |
MGI:5317553 |
| Age: |
embryonic day 10.5 |
|
|
| Specimen Label: |
E10.5 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317449 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610521 |
|
| Stage: |
TS21 |
| Assay Id: |
MGI:5317553 |
| Age: |
embryonic day 13.5 |
|
|
| Specimen Label: |
E13.5 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317449 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610523 |
|
| Stage: |
TS23 |
| Assay Id: |
MGI:5317553 |
| Age: |
embryonic day 15.5 |
|
|
| Specimen Label: |
E15.5 |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317449 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610525 |
|
| Stage: |
TS25 |
| Assay Id: |
MGI:5317553 |
| Age: |
embryonic day 17.5 |
|
|
| Specimen Label: |
E17.5 |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317449 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610527 |
|
| Stage: |
TS27 |
| Assay Id: |
MGI:5317553 |
| Age: |
postnatal newborn |
|
|
| Specimen Label: |
Neonate |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317449 |
| Assay Type: |
RT-PCR |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317553 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
Adult |
| Detected: |
true |
| Specimen Num: |
6 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317448 |
| Assay Type: |
Western blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317559 |
| Age: |
postnatal |
|
|
| Specimen Label: |
NTg |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317448 |
| Assay Type: |
Western blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317559 |
| Age: |
postnatal |
|
|
| Specimen Label: |
NTg |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317448 |
| Assay Type: |
Western blot |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1610528 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317559 |
| Age: |
postnatal |
|
|
| Specimen Label: |
NTg |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317448 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3268828 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:5317453 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
3A |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317448 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3268828 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:5317453 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
3B top |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317448 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3268828 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:5317453 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
3B bottom |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317448 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3268828 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:5317453 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
3C top |
| Detected: |
true |
| Specimen Num: |
4 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317448 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-05-08 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3268828 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:5317453 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
3C bottom |
| Detected: |
true |
| Specimen Num: |
5 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317448 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-05-08 |
| Strength: |
Absent |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3517628 |
|
| Stage: |
TS28 |
| Assay Id: |
MGI:5317453 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
3A |
| Detected: |
false |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5317448 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-05-08 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3517728 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:5317453 |
| Age: |
postnatal adult |
|
|
| Specimen Label: |
3A |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bastiani M |
| Year: |
2009 |
| Journal: |
J Cell Biol |
| Title: |
MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. |
| Volume: |
185 |
| Issue: |
7 |
| Pages: |
1259-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakanishi N |
| Year: |
2016 |
| Journal: |
Nat Commun |
| Title: |
MURC deficiency in smooth muscle attenuates pulmonary hypertension. |
| Volume: |
7 |
|
| Pages: |
12417 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miyagawa K |
| Year: |
2017 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Loss of MURC/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm. |
| Volume: |
487 |
| Issue: |
3 |
| Pages: |
587-593 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ludwig A |
| Year: |
2013 |
| Journal: |
PLoS Biol |
| Title: |
Molecular composition and ultrastructure of the caveolar coat complex. |
| Volume: |
11 |
| Issue: |
8 |
| Pages: |
e1001640 |
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2017 |
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J Cell Physiol |
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Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins. |
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232 |
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The Gene Ontology Consortium |
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2014 |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
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UniProt-GOA |
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2012 |
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Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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Mouse Genome Informatics Scientific Curators |
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2002 |
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Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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Kawai J |
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2001 |
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Nature |
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Functional annotation of a full-length mouse cDNA collection. |
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409 |
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MGD Nomenclature Committee |
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2020 |
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UniProt-GOA |
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2012 |
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Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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2002 |
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Nature |
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
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420 |
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6915 |
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The Gene Ontology Consortium |
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2010 |
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Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Mouse Genome Informatics Scientific Curators |
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2002 |
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Mouse Genome Informatics Computational Sequence to Gene Associations |
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Mouse Genome Informatics Scientific Curators |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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MGI Genome Annotation Group and UniGene Staff |
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2010 |
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Allen Institute for Brain Science |
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Allen Institute |
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Allen Brain Atlas: mouse riboprobes |
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Mouse Genome Informatics Scientific Curators |
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2009 |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
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2010 |
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Database Download |
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Consensus CDS project |
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Mouse Genome Informatics Group |
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2003 |
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Database Procedure |
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Mouse Genome Informatics Scientific Curators |
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2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Mouse Genome Informatics |
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2010 |
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Database Release |
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Mouse Genome Informatics Scientific Curators |
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2005 |
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Obtaining and loading genome assembly coordinates from NCBI annotations |
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Mouse Genome Informatics Scientific Curators |
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2009 |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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