Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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|
|
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•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
430
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
347
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kilstrup-Nielsen C |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
PBX1 nuclear export is regulated independently of PBX-MEINOX interaction by PKA phosphorylation of the PBC-B domain. |
Volume: |
22 |
Issue: |
1 |
Pages: |
89-99 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Activin regulation of the follicle-stimulating hormone beta-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1. |
|
•
•
•
•
•
|
Allele |
Name: |
pre B cell leukemia homeobox 1; endonuclease-mediated mutation 1, Sally L Dunwoodie |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Chao SH |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus. |
Volume: |
23 |
Issue: |
3 |
Pages: |
831-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Berry FB |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner. |
Volume: |
25 |
Issue: |
4 |
Pages: |
1415-24 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Pbx1/Pbx1 |
Background: |
C57BL/6J-Pbx1 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE82099 |
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu Q |
Year: |
1995 |
Journal: |
Mol Cell Biol |
Title: |
Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. |
Volume: |
15 |
Issue: |
7 |
Pages: |
3786-95 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE39605 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
102
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
93
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
147
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
96
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
108
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
86
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
44
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
78
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
128
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
54
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Bürglin TR |
Year: |
1992 |
Journal: |
Nat Genet |
Title: |
New motif in PBX genes. |
Volume: |
1 |
Issue: |
5 |
Pages: |
319-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Joo S |
Year: |
2018 |
Journal: |
BMC Biol |
Title: |
Common ancestry of heterodimerizing TALE homeobox transcription factors across Metazoa and Archaeplastida. |
Volume: |
16 |
Issue: |
1 |
Pages: |
136 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Pbx proteins are members of the TALE (three-amino-acid loop extension) family of atypical homeodomain proteins, whose membersare characterised by a three-residue insertion between helix 1 and 2 and plays essential roles during embryonic development by participating in interactive TF networks. The heterodimerization of TALE proteins serves as a trigger for precise execution of developmental programs. Examinationof Pbx1 has shown that, in addition to the homeodomain, a short 16-residue C-terminal tail is essential for maximal cooperative interactions withHox partners as well as for maximal monomeric binding of Pbx1 to DNA. The PCB domain is a bipartite acidic domain that can be further subdivided into an A and B region [, , ]. |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Bürglin TR |
Year: |
1997 |
Journal: |
Nucleic Acids Res |
Title: |
Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals. |
Volume: |
25 |
Issue: |
21 |
Pages: |
4173-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mukherjee K |
Year: |
2007 |
Journal: |
J Mol Evol |
Title: |
Comprehensive analysis of animal TALE homeobox genes: new conserved motifs and cases of accelerated evolution. |
Volume: |
65 |
Issue: |
2 |
Pages: |
137-53 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (SMARCD3 or BAF60C) is a component of several complexes that remodel chromatin, a mechanism by which selected genes are transcriptionally activated or repressed. The complexes are SWI/SNF, which changes chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner []; BAF []; and the npBAF and nBAF, which are neuron-specific []. SMARCD3 is known to interact with a number of proteins, including SMARCA4/BRG1/BAF190A []and the homeobox protein PBX1 []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Hao X |
Year: |
2006 |
Journal: |
Leuk Res |
Title: |
Histologic and molecular characterizations of megakaryocytic leukemia in mice. |
Volume: |
30 |
Issue: |
4 |
Pages: |
397-406 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Debril MB |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. |
Volume: |
279 |
Issue: |
16 |
Pages: |
16677-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu J |
Year: |
2010 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1. |
Volume: |
107 |
Issue: |
47 |
Pages: |
20494-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
1999 |
Journal: |
Mamm Genome |
Title: |
Sequence and genomic organization of the mouse Lim1 gene. |
Volume: |
10 |
Issue: |
5 |
Pages: |
444-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matis C |
Year: |
2007 |
Journal: |
Dev Dyn |
Title: |
Identification of Lmo1 as part of a Hox-dependent regulatory network for hindbrain patterning. |
Volume: |
236 |
Issue: |
9 |
Pages: |
2675-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horman SR |
Year: |
2009 |
Journal: |
Blood |
Title: |
Gfi1 integrates progenitor versus granulocytic transcriptional programming. |
Volume: |
113 |
Issue: |
22 |
Pages: |
5466-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukuda S |
Year: |
2015 |
Journal: |
Leukemia |
Title: |
Survivin modulates genes with divergent molecular functions and regulates proliferation of hematopoietic stem cells through Evi-1. |
Volume: |
29 |
Issue: |
2 |
Pages: |
433-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mamo A |
Year: |
2006 |
Journal: |
Blood |
Title: |
Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation. |
Volume: |
108 |
Issue: |
2 |
Pages: |
622-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Olatoke T |
Year: |
2023 |
Journal: |
Sci Adv |
Title: |
Single-cell multiomic analysis identifies a HOX-PBX gene network regulating the survival of lymphangioleiomyomatosis cells. |
Volume: |
9 |
Issue: |
19 |
Pages: |
eadf8549 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang W |
Year: |
1996 |
Journal: |
Genes Dev |
Title: |
Diversity and specialization of mammalian SWI/SNF complexes. |
Volume: |
10 |
Issue: |
17 |
Pages: |
2117-30 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
378
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Fu X |
Year: |
1997 |
Journal: |
Mol Cell Biol |
Title: |
E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. |
Volume: |
17 |
Issue: |
3 |
Pages: |
1503-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dutta A |
Year: |
2021 |
Journal: |
Leukemia |
Title: |
U2af1 is required for survival and function of hematopoietic stem/progenitor cells. |
Volume: |
35 |
Issue: |
8 |
Pages: |
2382-2398 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oriente F |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism. |
Volume: |
28 |
Issue: |
18 |
Pages: |
5634-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oriente F |
Year: |
2011 |
Journal: |
Diabetes |
Title: |
Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphatase. |
Volume: |
60 |
Issue: |
1 |
Pages: |
138-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shepherd MS |
Year: |
2018 |
Journal: |
Blood |
Title: |
Single-cell approaches identify the molecular network driving malignant hematopoietic stem cell self-renewal. |
Volume: |
132 |
Issue: |
8 |
Pages: |
791-803 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jung JG |
Year: |
2016 |
Journal: |
Cancer Res |
Title: |
Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1. |
Volume: |
76 |
Issue: |
21 |
Pages: |
6351-6361 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di Rocco G |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
The recruitment of SOX/OCT complexes and the differential activity of HOXA1 and HOXB1 modulate the Hoxb1 auto-regulatory enhancer function. |
Volume: |
276 |
Issue: |
23 |
Pages: |
20506-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Di Giacomo G |
Year: |
2006 |
Journal: |
Gene Expr Patterns |
Title: |
Spatio-temporal expression of Pbx3 during mouse organogenesis. |
Volume: |
6 |
Issue: |
7 |
Pages: |
747-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Risolino M |
Year: |
2014 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma. |
Volume: |
111 |
Issue: |
36 |
Pages: |
E3775-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lange M |
Year: |
2008 |
Journal: |
Genes Dev |
Title: |
Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. |
Volume: |
22 |
Issue: |
17 |
Pages: |
2370-84 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
430
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
434
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
370
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
430
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
347
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
430
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
430
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
430
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
348
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Lessard J |
Year: |
2007 |
Journal: |
Neuron |
Title: |
An essential switch in subunit composition of a chromatin remodeling complex during neural development. |
Volume: |
55 |
Issue: |
2 |
Pages: |
201-15 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
483
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
454
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|