Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:2664141 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752522 |
|
Stage: |
TS22 |
Assay Id: |
MGI:2666380 |
Age: |
embryonic day 14.5 |
Image: |
BG071784 14.5dpc |
|
Specimen Label: |
BG071784 14.5dpc |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664141 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1668822 |
|
Stage: |
TS22 |
Assay Id: |
MGI:2666380 |
Age: |
embryonic day 14.5 |
Image: |
BG071784 14.5dpc |
|
Specimen Label: |
BG071784 14.5dpc |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664141 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1757722 |
|
Stage: |
TS22 |
Assay Id: |
MGI:2666380 |
Age: |
embryonic day 14.5 |
Image: |
BG071784 14.5dpc |
|
Specimen Label: |
BG071784 14.5dpc |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664141 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689417 |
Pattern: |
Not Specified |
Stage: |
TS17 |
Assay Id: |
MGI:2666380 |
Age: |
embryonic day 10.5 |
Image: |
BG071784 10.5dpc |
|
Specimen Label: |
BG071784 10.5dpc |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2664141 |
Assay Type: |
RNA in situ |
Annotation Date: |
2003-07-21 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1796222 |
|
Stage: |
TS22 |
Assay Id: |
MGI:2666380 |
Age: |
embryonic day 14.5 |
Image: |
BG071784 14.5dpc |
|
Specimen Label: |
BG071784 14.5dpc |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Angulo G |
Year: |
2021 |
Journal: |
Elife |
Title: |
Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion. |
Volume: |
10 |
|
|
|
•
•
•
•
•
|
Allele |
Name: |
icos ligand; targeted mutation 1, Tak W Mak |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
322
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
347
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Allele |
Name: |
icos ligand; endonuclease-mediated mutation 3, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
icos ligand; targeted mutation 3, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence, Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
icos ligand; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
icos ligand; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Allele |
Name: |
inducible T cell co-stimulator; targeted mutation 1, Tak Mak |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Wikenheiser DJ |
Year: |
2016 |
Journal: |
J Immunol |
Title: |
The Costimulatory Molecule ICOS Regulates Host Th1 and Follicular Th Cell Differentiation in Response to Plasmodium chabaudi chabaudi AS Infection. |
Volume: |
196 |
Issue: |
2 |
Pages: |
778-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Busse M |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
ICOS mediates the generation and function of CD4+CD25+Foxp3+ regulatory T cells conveying respiratory tolerance. |
Volume: |
189 |
Issue: |
4 |
Pages: |
1975-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vidric M |
Year: |
2006 |
Journal: |
Infect Immun |
Title: |
Role for inducible costimulator in control of Salmonella enterica serovar Typhimurium infection in mice. |
Volume: |
74 |
Issue: |
2 |
Pages: |
1050-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buus TB |
Year: |
2016 |
Journal: |
Oncotarget |
Title: |
Development of interleukin-17-producing Vγ2+ γδ T cells is reduced by ICOS signaling in the thymus. |
Volume: |
7 |
Issue: |
15 |
Pages: |
19341-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tada Y |
Year: |
2006 |
Journal: |
Clin Immunol |
Title: |
Role of inducible costimulator in the development of lupus in MRL/lpr mice. |
Volume: |
120 |
Issue: |
2 |
Pages: |
179-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bossaller L |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells. |
Volume: |
177 |
Issue: |
7 |
Pages: |
4927-32 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Icos/Icos |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Icos/Icos |
Background: |
B6.129P2-Icos/J |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Colino J |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Noncovalent association of protein and capsular polysaccharide on bacteria-sized latex beads as a model for polysaccharide-specific humoral immunity to intact gram-positive extracellular bacteria. |
Volume: |
191 |
Issue: |
6 |
Pages: |
3254-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vu F |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction. |
Volume: |
180 |
Issue: |
4 |
Pages: |
2284-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vidric M |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
Cooperation between 4-1BB and ICOS in the immune response to influenza virus revealed by studies of CD28/ICOS-deficient mice. |
Volume: |
175 |
Issue: |
11 |
Pages: |
7288-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suh WK |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28. |
Volume: |
172 |
Issue: |
10 |
Pages: |
5917-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marks E |
Year: |
2007 |
Journal: |
Infect Immun |
Title: |
Differential CD28 and inducible costimulatory molecule signaling requirements for protective CD4+ T-cell-mediated immunity against genital tract Chlamydia trachomatis infection. |
Volume: |
75 |
Issue: |
9 |
Pages: |
4638-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moguche AO |
Year: |
2015 |
Journal: |
J Exp Med |
Title: |
ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis. |
Volume: |
212 |
Issue: |
5 |
Pages: |
715-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huo F |
Year: |
2019 |
Journal: |
Immunobiology |
Title: |
Aire deficient dendritic cells promote the T follicular helper cells differentiation. |
Volume: |
224 |
Issue: |
4 |
Pages: |
539-550 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pratama A |
Year: |
2015 |
Journal: |
Nat Commun |
Title: |
MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres. |
Volume: |
6 |
|
Pages: |
6436 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arjunaraja S |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
The nature of an in vivo anti-capsular polysaccharide response is markedly influenced by the composition and/or architecture of the bacterial subcapsular domain. |
Volume: |
188 |
Issue: |
2 |
Pages: |
569-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bertram EM |
Year: |
2002 |
Journal: |
Eur J Immunol |
Title: |
Role of ICOS versus CD28 in antiviral immunity. |
Volume: |
32 |
Issue: |
12 |
Pages: |
3376-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bergqvist P |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers. |
Volume: |
177 |
Issue: |
11 |
Pages: |
7772-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao X |
Year: |
2013 |
Journal: |
Mol Med |
Title: |
Enhanced inducible costimulator ligand (ICOS-L) expression on dendritic cells in interleukin-10 deficiency and its impact on T-cell subsets in respiratory tract infection. |
Volume: |
19 |
Issue: |
1 |
Pages: |
346-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilson EH |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses. |
Volume: |
177 |
Issue: |
4 |
Pages: |
2365-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice. |
Volume: |
191 |
Issue: |
1 |
Pages: |
200-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao X |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Anti-chlamydial Th17 responses are controlled by the inducible costimulator partially through phosphoinositide 3-kinase signaling. |
Volume: |
7 |
Issue: |
12 |
Pages: |
e52657 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mittelsteadt KL |
Year: |
2021 |
Journal: |
J Exp Med |
Title: |
ICOS signaling limits regulatory T cell accumulation and function in visceral adipose tissue. |
Volume: |
218 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
O'Brien CA |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain. |
Volume: |
15 |
Issue: |
1 |
Pages: |
e0228251 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lownik JC |
Year: |
2019 |
Journal: |
J Immunol |
Title: |
B Cell ADAM10 Controls Murine Lupus Progression through Regulation of the ICOS:ICOS Ligand Axis. |
Volume: |
202 |
Issue: |
3 |
Pages: |
664-674 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burbage M |
Year: |
2018 |
Journal: |
Elife |
Title: |
Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity. |
Volume: |
7 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Robays LJ |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Concomitant inhalation of cigarette smoke and aerosolized protein activates airway dendritic cells and induces allergic airway inflammation in a TLR-independent way. |
Volume: |
183 |
Issue: |
4 |
Pages: |
2758-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matsuo T |
Year: |
2019 |
Journal: |
J Immunol |
Title: |
Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation. |
Volume: |
202 |
Issue: |
11 |
Pages: |
3161-3172 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kosuge H |
Year: |
2006 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Critical role of inducible costimulator signaling in the development of arteriosclerosis. |
Volume: |
26 |
Issue: |
12 |
Pages: |
2660-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
O'Brien CA |
Year: |
2019 |
Journal: |
J Immunol |
Title: |
IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic Toxoplasma gondii Infection. |
Volume: |
202 |
Issue: |
6 |
Pages: |
1755-1766 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma B |
Year: |
2022 |
Journal: |
Front Immunol |
Title: |
CHI3L1 enhances melanoma lung metastasis via regulation of T cell co-stimulators and CTLA-4/B7 axis. |
Volume: |
13 |
|
Pages: |
1056397 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakae S |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF. |
Volume: |
176 |
Issue: |
4 |
Pages: |
2238-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marriott CL |
Year: |
2015 |
Journal: |
Eur J Immunol |
Title: |
ICOS is required for the generation of both central and effector CD4(+) memory T-cell populations following acute bacterial infection. |
Volume: |
45 |
Issue: |
6 |
Pages: |
1706-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma J |
Year: |
2021 |
Journal: |
Aging (Albany NY) |
Title: |
Follistatin-like 1 deficiency impairs T cell development to promote lung metastasis of triple negative breast cancer. |
Volume: |
13 |
Issue: |
5 |
Pages: |
7211-7227 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hastey CJ |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
Delays and diversions mark the development of B cell responses to Borrelia burgdorferi infection. |
Volume: |
188 |
Issue: |
11 |
Pages: |
5612-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Q |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine. |
Volume: |
181 |
Issue: |
12 |
Pages: |
8258-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Verma M |
Year: |
2021 |
Journal: |
J Exp Med |
Title: |
The molecular and epigenetic mechanisms of innate lymphoid cell (ILC) memory and its relevance for asthma. |
Volume: |
218 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Gigoux M |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. |
Volume: |
106 |
Issue: |
48 |
Pages: |
20371-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wan Z |
Year: |
2020 |
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Sci Immunol |
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