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Search results 301 to 400 out of 2086 for Lck

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Type Details Score
Publication
7590745 | J:26632
First Author: Danciger M
Year: 1995
Journal: Genomics
Title: Chromosomal localization of the genes for five zinc finger proteins expressed in mouse lens.
Volume: 28
Issue: 1
Pages: 39-43
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Publication
- | J:36
First Author: Greenfield AJ
Year: 1992
Journal: Mouse Genome
Title: Mappping of clone D4Smh6b to the distal end of mouse chromosome 4
Volume: 90
Issue: 1
Pages: 94-95
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Publication
1684952 | J:3321
First Author: Bahary N
Year: 1991
Journal: Genomics
Title: Molecular genetic linkage maps of mouse chromosomes 4 and 6.
Volume: 11
Issue: 1
Pages: 33-47
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Publication
8464923 | J:4377
First Author: Gregor P
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.
Volume: 90
Issue: 7
Pages: 3053-7
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Publication
8390965 | J:4958
First Author: Taylor BA
Year: 1993
Journal: Genomics
Title: The MEV mouse linkage testing stock: mapping 30 novel proviral insertions and establishment of an improved stock.
Volume: 16
Issue: 2
Pages: 380-94
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Publication
23616926 | J:194960
First Author: Tai G
Year: 2013
Journal: Biol Open
Title: FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique.
Volume: 2
Issue: 4
Pages: 416-23
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Publication
23793062 | J:205441
First Author: Liang Y
Year: 2013
Journal: Nat Immunol
Title: The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
Volume: 14
Issue: 8
Pages: 858-66
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Publication
19164599 | J:147173
First Author: Sultana DA
Year: 2009
Journal: Blood
Title: Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development.
Volume: 113
Issue: 13
Pages: 2976-87
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
11114734 | J:66153
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:345476
       
First Author: Haiming Tang, Dustin Ebert, Matthias Blum, Robert Finn, Paul Thomas
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Strain
MGI:4834638 | B6.Cg-Tg(Lck-FADD)1Hed/Ieg
Attribute String: transgenic, mutant strain, congenic
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Protein Coding Gene
MGI:1919949 | Lime1
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
362289 | Lime1
Type: gene
Organism: rat
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Gene
100140162 | LIME1
Type: gene
Organism: cattle
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Gene
100615345 | LIME1
Type: gene
Organism: chimpanzee
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Gene
100687818 | LIME1
Type: gene
Organism: dog, domestic
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Gene
425299 | LIME1
Type: gene
Organism: chicken
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Gene
100005368 | lime1
Type: gene
Organism: zebrafish
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Gene
100425312 | LIME1
Type: gene
Organism: macaque, rhesus
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Gene
100489775 | lime1
Type: gene
Organism: frog, western clawed
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Publication
1588967 | J:1262
First Author: Allen JM
Year: 1992
Journal: Mol Cell Biol
Title: Functional dissection of the lck proximal promoter.
Volume: 12
Issue: 6
Pages: 2758-68
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Strain
MGI:5317423 | STOCK Tg(Lck-AVEN)1Zrng/Ieg
Attribute String: mutant stock, transgenic
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UniProt Feature
UniProt Feature
Begin: 90
Description: Phosphotyrosine; by LCK
Type: modified residue
End: 90
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UniProt Feature
UniProt Feature
Begin: 517
Description: Phosphotyrosine; by LCK
Type: modified residue
End: 517
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UniProt Feature
UniProt Feature
Begin: 2
Description: Proto-oncogene tyrosine-protein kinase LCK
Type: chain
End: 509
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UniProt Feature
UniProt Feature
Begin: 314
Description: Phosphotyrosine; by LCK
Type: modified residue
End: 314
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Allele
Tg(LCK-NFKBIA)5Dwb | MGI:3056807
Name: transgene insertion 5, Dean W Ballard
Allele Type: Transgenic
Attribute String: Dominant negative, Humanized sequence, Inserted expressed sequence
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Protein
P06240
Organism: Mus musculus/domesticus
Length: 509  
Fragment?: false
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Gene
100036955 | lck.L
Type: gene
Organism: frog, African clawed
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Gene
108708930 | lck.S
Type: gene
Organism: frog, African clawed
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Publication
3380790 | -
First Author: Benavente J
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: Avian reovirus mRNAs are nonfunctional in infected mouse cells: translational basis for virus host-range restriction.
Volume: 85
Issue: 12
Pages: 4257-61
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Publication
2107025 | -
First Author: Turner JM
Year: 1990
Journal: Cell
Title: Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs.
Volume: 60
Issue: 5
Pages: 755-65
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Publication
1706070 | -
First Author: Abraham N
Year: 1991
Journal: Nature
Title: Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.
Volume: 350
Issue: 6313
Pages: 62-6
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Publication
8371758 | -
First Author: Chow LM
Year: 1993
Journal: Nature
Title: Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk.
Volume: 365
Issue: 6442
Pages: 156-60
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Publication
8421674 | -
First Author: Carrera AC
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP.
Volume: 90
Issue: 2
Pages: 442-6
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Protein
B2KG65
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Publication
30523347 | J:322112
First Author: Wan Z
Year: 2020
Journal: Cell Mol Immunol
Title: Transmembrane domain-mediated Lck association underlies bystander and costimulatory ICOS signaling.
Volume: 17
Issue: 2
Pages: 143-152
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Strain
MGI:5317746 | B6.Cg-Tg(Lck-CFLAR)1Zrng/Ieg
Attribute String: congenic, mutant strain, transgenic
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UniProt Feature
UniProt Feature
Begin: 736
Description: Phosphotyrosine; by HCK and LCK
Type: modified residue
End: 736
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UniProt Feature
UniProt Feature
Begin: 716
Description: Phosphotyrosine; by HCK and LCK
Type: modified residue
End: 716
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UniProt Feature
UniProt Feature
Begin: 261
Description: Phosphotyrosine; by LYN or LCK
Type: modified residue
End: 261
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UniProt Feature
UniProt Feature
Begin: 242
Description: Phosphotyrosine; by LYN or LCK
Type: modified residue
End: 242
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Allele
Lime1<+> | MGI:3575633
   
Name: Lck interacting transmembrane adaptor 1; wild type
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Publication
10970857 | J:64671
First Author: Baker M
Year: 2000
Journal: EMBO J
Title: Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice.
Volume: 19
Issue: 17
Pages: 4644-54
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Publication
16257509 | -
First Author: Fukushima A
Year: 2006
Journal: Cell Signal
Title: Lck couples Shc to TCR signaling.
Volume: 18
Issue: 8
Pages: 1182-9
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Publication
21983898 | -
First Author: Patrussi L
Year: 2012
Journal: Apoptosis
Title: p66Shc-dependent apoptosis requires Lck and CamKII activity.
Volume: 17
Issue: 2
Pages: 174-86
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Publication
25263124 | J:259376
First Author: Zhou RW
Year: 2014
Journal: Nat Immunol
Title: N-glycosylation bidirectionally extends the boundaries of thymocyte positive selection by decoupling Lck from Ca²⁺ signaling.
Volume: 15
Issue: 11
Pages: 1038-45
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Publication
36564464 | J:337691
First Author: Horkova V
Year: 2023
Journal: Nat Immunol
Title: Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells.
Volume: 24
Issue: 1
Pages: 174-185
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Publication
15905512 | J:99042
First Author: Zhang DJ
Year: 2005
Journal: J Immunol
Title: Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene.
Volume: 174
Issue: 11
Pages: 6725-31
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DO Term
DOID:0111937 | immunodeficiency 22
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Publication
33684096 | J:305803
First Author: Sripada A
Year: 2021
Journal: PLoS Biol
Title: Sprouty2 positively regulates T cell function and airway inflammation through regulation of CSK and LCK kinases.
Volume: 19
Issue: 3
Pages: e3001063
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Publication
12496963 | J:265600
First Author: Irles C
Year: 2003
Journal: Nat Immunol
Title: CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling.
Volume: 4
Issue: 2
Pages: 189-97
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Publication
22507872 | J:188303
First Author: Mahon RN
Year: 2012
Journal: Cell Immunol
Title: Mycobacterium tuberculosis ManLAM inhibits T-cell-receptor signaling by interference with ZAP-70, Lck and LAT phosphorylation.
Volume: 275
Issue: 1-2
Pages: 98-105
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UniProt Feature
UniProt Feature
Begin: 580
Description: Phosphotyrosine; by SRC, FYN and LCK
Type: modified residue
End: 580
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UniProt Feature
UniProt Feature
Begin: 515
Description: Phosphotyrosine; by INSR, SRC and LCK
Type: modified residue
End: 515
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Publication
14610046 | J:289012
First Author: Brdicková N
Year: 2003
Journal: J Exp Med
Title: LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.
Volume: 198
Issue: 10
Pages: 1453-62
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Publication
9647223 | J:110916
First Author: Irie HY
Year: 1998
Journal: J Immunol
Title: The cytoplasmic domain of CD8 beta regulates Lck kinase activation and CD8 T cell development.
Volume: 161
Issue: 1
Pages: 183-91
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Publication
23931554 | J:200992
First Author: Ventimiglia LN
Year: 2013
Journal: Biochem J
Title: The role of membrane rafts in Lck transport, regulation and signalling in T-cells.
Volume: 454
Issue: 2
Pages: 169-79
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Publication
9670936 | J:48581
First Author: Takemoto Y
Year: 1998
Journal: J Immunol
Title: Growth factor receptor-bound protein 2 (Grb2) association with hemopoietic specific protein 1: linkage between Lck and Grb2.
Volume: 161
Issue: 2
Pages: 625-30
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Allele
Lime1<tm1.1Mal> | MGI:3762394
Name: Lck interacting transmembrane adaptor 1; targeted mutation 1.1, Bernard Malissen
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
16446380 | J:118955
First Author: Marti F
Year: 2006
Journal: J Exp Med
Title: Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells.
Volume: 203
Issue: 2
Pages: 281-7
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Publication
17277109 | J:143998
First Author: Falahati R
Year: 2007
Journal: J Immunol
Title: Changes in the role of the CD45 protein tyrosine phosphatase in regulating Lck tyrosine phosphorylation during thymic development.
Volume: 178
Issue: 4
Pages: 2056-64
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Publication
35860252 | J:330231
 
First Author: Damen H
Year: 2022
Journal: Front Immunol
Title: Negative Regulation of Zap70 by Lck Forms the Mechanistic Basis of Differential Expression in CD4 and CD8 T Cells.
Volume: 13
Pages: 935367
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Publication
- | J:171186
     
First Author: Petrie H
Year: 2011
Journal: MGI Direct Data Submission
Title: A new transgenic mouse expressing Lyl1 (lymphoblastic leukemia 1) under the control of an Lck promoter
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Publication
7736574 | J:24973
First Author: Miyazaki T
Year: 1995
Journal: Cell
Title: Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation.
Volume: 81
Issue: 2
Pages: 223-31
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Publication
35365636 | J:323939
First Author: Jacobsen AV
Year: 2022
Journal: Cell Death Dis
Title: The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL.
Volume: 13
Issue: 4
Pages: 291
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Transgene
MGI:3056808 | Tg(LCK-NFKBIA)5Dwb
Type: transgene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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