Human FBXL5 (F-box and leucine-rich repeat protein 5) protein plays a role in cellular iron homeostasis []. It is part of an E3 ubiquitin ligase complex that targets the iron regulatory protein IRP2 for proteasomal degradation []. The FBXL5's stability is regulated by iron concentration, with its iron- and oxygen-binding hemerythrin domain acting as a ligand-dependent regulatory switch [, , ].
