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Search results 1301 to 1400 out of 2191 for MBP

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Type Details Score
Allele
Name: transgene insertion 30, Brian Schaefer
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion 1, Shioko Kimura
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: transgene insertion 53, Masahiro Sato
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: transgene insertion 29, Masayuki Miura
Allele Type: Transgenic
Attribute String: Recombinase
Allele
Name: immunoglobulin kappa chain complex; targeted mutation 3.1, Velocigene
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
Allele
Name: transgene insertion, Kouichi Ito
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Publication
First Author: Hardardottir F
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: T cells with two functional antigen-specific receptors.
Volume: 92
Issue: 2
Pages: 354-8
Publication
First Author: Jones RE
Year: 2003
Journal: J Immunol
Title: Epitope spreading is not required for relapses in experimental autoimmune encephalomyelitis.
Volume: 170
Issue: 4
Pages: 1690-8
Allele
Name: L1 cell adhesion molecule; endonuclease-mediated mutation 1, Melitta Schachner
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
Allele
Name: L1 cell adhesion molecule; endonuclease-mediated mutation 2, Melitta Schachner
Allele Type: Endonuclease-mediated
Attribute String: Not Specified
Allele  
Name: intergenic site 77; endonuclease-mediated mutation 1, Andrea Ventura
Allele Type: Endonuclease-mediated
Allele  
Name: intergenic site 78; endonuclease-mediated mutation 1, Andrea Ventura
Allele Type: Endonuclease-mediated
Allele  
Name: intergenic site 79; endonuclease-mediated mutation 1, Andrea Ventura
Allele Type: Endonuclease-mediated
Allele  
Name: intergenic site 80; endonuclease-mediated mutation 1, Andrea Ventura
Allele Type: Endonuclease-mediated
HT Experiment
Series Id: GSE37902
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Publication
First Author: Emery B
Year: 2009
Journal: Cell
Title: Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination.
Volume: 138
Issue: 1
Pages: 172-85
Publication
First Author: Koenning M
Year: 2012
Journal: J Neurosci
Title: Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS.
Volume: 32
Issue: 36
Pages: 12528-42
Publication
First Author: Inouye H
Year: 1991
Journal: J Neurosci Res
Title: Folding and function of the myelin proteins from primary sequence data.
Volume: 28
Issue: 1
Pages: 1-17
Publication
First Author: Senoo H
Year: 2012
Journal: Int J Dev Biol
Title: An orthologue of the Myelin-gene Regulatory Transcription Factor regulates Dictyostelium prestalk differentiation.
Volume: 56
Issue: 5
Pages: 325-32
Publication
First Author: Russel S
Year: 2011
Journal: Dev Biol
Title: Regulation of the C. elegans molt by pqn-47.
Volume: 360
Issue: 2
Pages: 297-309
Protein Domain
Type: Family
Description: This entry represents metazoan myelin gene regulatory factor (MRF). MRF is a transcription regulator required in vertebrates for expression of central nervous system (CNS) myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and CNS myelination []. It is also required for the maintenance of expression of myelin genes and the mature oligodendrocytes identity in the adult CNS []. A Caenorhabditis elegans orthologue, pqn-47, may function as a regulator of molting [], while a Dictyostelium orthologue has been described to regulate prestalk differentiation [].
Protein Domain
Type: Domain
Description: Myelin regulatory factor (Myrf) is a transcription regulator required in vertebrates for expression of central nervous system (CNS) myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and CNS myelination []. It is also required for the maintenance of expression of myelin genes and the mature oligodendrocytes identity in the adult CNS [, ]. A Caenorhabditis elegans orthologue, pqn-47, may function as a regulator of molting [], while a Dictyostelium orthologue has been described to regulate prestalk differentiation [].This domain is found at the C terminus of myelin regulatory factor. The function of the domain is not known.
Publication
First Author: Kawamura K
Year: 2008
Journal: J Immunol
Title: Different development of myelin basic protein agonist- and antagonist-specific human TCR transgenic T cells in the thymus and periphery.
Volume: 181
Issue: 8
Pages: 5462-72
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: An H
Year: 2020
Journal: Sci Rep
Title: Functional mechanism and pathogenic potential of MYRF ICA domain mutations implicated in birth defects.
Volume: 10
Issue: 1
Pages: 814
Publication
First Author: Holmskov U
Year: 1994
Journal: Immunol Today
Title: Collectins: collagenous C-type lectins of the innate immune defense system.
Volume: 15
Issue: 2
Pages: 67-74
Publication  
First Author: Stuart LM
Year: 2006
Journal: Curr Dir Autoimmun
Title: Collectins: opsonins for apoptotic cells and regulators of inflammation.
Volume: 9
Pages: 143-61
Publication
First Author: Presanis JS
Year: 2003
Journal: Biochem Soc Trans
Title: Biochemistry and genetics of mannan-binding lectin (MBL).
Volume: 31
Issue: Pt 4
Pages: 748-52
Publication
First Author: Kishore U
Year: 2006
Journal: Mol Immunol
Title: Surfactant proteins SP-A and SP-D: structure, function and receptors.
Volume: 43
Issue: 9
Pages: 1293-315
Publication  
First Author: Jack DL
Year: 2001
Journal: Immunol Rev
Title: Mannose-binding lectin: targeting the microbial world for complement attack and opsonophagocytosis.
Volume: 180
Pages: 86-99
Publication
First Author: Kuhlman M
Year: 1989
Journal: J Exp Med
Title: The human mannose-binding protein functions as an opsonin.
Volume: 169
Issue: 5
Pages: 1733-45
Publication
First Author: Akella A
Year: 2013
Journal: Indian J Exp Biol
Title: Pulmonary surfactants and their role in pathophysiology of lung disorders.
Volume: 51
Issue: 1
Pages: 5-22
Publication
First Author: Heitzeneder S
Year: 2012
Journal: Clin Immunol
Title: Mannan-binding lectin deficiency - Good news, bad news, doesn't matter?
Volume: 143
Issue: 1
Pages: 22-38
Protein Domain
Type: Domain
Description: This entry represents the C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose-binding lectin (MBL, also known as mannan-binding protein or MBP), and CL-L1 (collectin liver 1) [, ]. CTLD refers to a domain, homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins [].The CTLDs of these collectins bind carbohydrates on surfaces (e.g. pathogens, allergens, necrotic, or apoptotic cells) and mediate functions associated with killing and phagocytosis. MBPs recognize high mannose oligosaccharides in a calcium dependent manner, bind to a broad range of pathogens, and trigger cell killing by activating the complement pathway [, ]. MBP also acts directly as an opsonin []. SP-A and SP-D in addition to functioning as host defense components, are components of pulmonary surfactant which play a role in surfactant homeostasis [, ]. Pulmonary surfactant is a phospholipid-protein complex which reduces the surface tension within the lungs. SP-A binds the major surfactant lipid: dipalmitoylphosphatidylcholine (DPPC). SP-D binds two minor components of surfactant that contain sugar moieties: glucosylceramide and phosphatidylinositol (PI). MBP and SP-A, -D monomers are homotrimers with an N-terminal collagen region and three CTLDs. Multiple homotrimeric units associate to form supramolecular complexes. MBL deficiency results in an increased susceptibility to a large number of different infections and to inflammatory disease [].
Allele  
Name: myelin basic protein; myelin deficient
Allele Type: Spontaneous
Publication
First Author: Ponomarev ED
Year: 2007
Journal: J Immunol
Title: GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis.
Volume: 178
Issue: 1
Pages: 39-48
Publication
First Author: Grewal IS
Year: 2001
Journal: Immunity
Title: CD62L is required on effector cells for local interactions in the CNS to cause myelin damage in experimental allergic encephalomyelitis.
Volume: 14
Issue: 3
Pages: 291-302
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: mutant strain, transgenic, coisogenic
Strain
Attribute String: transgenic, mutant strain, congenic
Strain
Attribute String: F1 hybrid, transgenic
Publication  
First Author: Singh V
Year: 2014
Journal: Exp Eye Res
Title: TGFβ and PDGF-B signaling blockade inhibits myofibroblast development from both bone marrow-derived and keratocyte-derived precursor cells in vivo.
Volume: 121
Pages: 35-40
Publication
First Author: Liu S
Year: 2020
Journal: J Immunol
Title: Mapping the Chromosomal Insertion Site of the GFP Transgene of UBC-GFP Mice to the MHC Locus.
Volume: 204
Issue: 7
Pages: 1982-1987
Publication
First Author: Peters NC
Year: 2014
Journal: PLoS Pathog
Title: Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection.
Volume: 10
Issue: 12
Pages: e1004538
Publication
First Author: Glass AM
Year: 2013
Journal: Comp Med
Title: Spontaneous cardiac calcinosis in BALB/cByJ mice.
Volume: 63
Issue: 1
Pages: 29-37
Publication
First Author: Staffas A
Year: 2018
Journal: Cell Host Microbe
Title: Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.
Volume: 23
Issue: 4
Pages: 447-457.e4
Publication
First Author: Lee Eh
Year: 2013
Journal: PLoS One
Title: Overexpression of apolipoprotein A1 in the lung abrogates fibrosis in experimental silicosis.
Volume: 8
Issue: 2
Pages: e55827
Publication
First Author: Bajénoff M
Year: 2008
Journal: J Immunol
Title: Fibroblastic reticular cells guide T lymphocyte entry into and migration within the splenic T cell zone.
Volume: 181
Issue: 6
Pages: 3947-54
Publication  
First Author: Åšwierczek-Lasek B
Year: 2022
Journal: Cells
Title: Comparison of Muscle Regeneration after BMSC-Conditioned Medium, Syngeneic, or Allogeneic BMSC Injection.
Volume: 11
Issue: 18
Publication
First Author: Naik SH
Year: 2007
Journal: Nat Immunol
Title: Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo.
Volume: 8
Issue: 11
Pages: 1217-26
Publication
First Author: Kirschenbaum D
Year: 2024
Journal: Cell
Title: Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma.
Volume: 187
Issue: 1
Pages: 149-165.e23
Publication  
First Author: Mandal A
Year: 2018
Journal: Sci Transl Med
Title: Cell and fluid sampling microneedle patches for monitoring skin-resident immunity.
Volume: 10
Issue: 467
Publication
First Author: Ramos CA
Year: 2020
Journal: iScience
Title: A Non-canonical Function of BMAL1 Metabolically Limits Obesity-Promoted Triple-Negative Breast Cancer.
Volume: 23
Issue: 2
Pages: 100839
Publication  
First Author: Singh V
Year: 2013
Journal: Exp Eye Res
Title: A method to generate enhanced GFP+ chimeric mice to study the role of bone marrow-derived cells in the eye.
Volume: 116
Pages: 366-70
Publication
First Author: Bajénoff M
Year: 2006
Journal: Immunity
Title: Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes.
Volume: 25
Issue: 6
Pages: 989-1001
Publication
First Author: Povinelli BJ
Year: 2015
Journal: Exp Hematol
Title: Related-to-receptor tyrosine kinase receptor regulates hematopoietic stem and progenitor sensitivity to myelosuppressive injury in mice.
Volume: 43
Issue: 3
Pages: 243-252.e1
Publication
First Author: Zhang S
Year: 2014
Journal: Stem Cells
Title: Interleukin 6 mediates the therapeutic effects of adipose-derived stromal/stem cells in lipopolysaccharide-induced acute lung injury.
Volume: 32
Issue: 6
Pages: 1616-28
Publication
First Author: Yurchenko E
Year: 2012
Journal: PLoS One
Title: Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo.
Volume: 7
Issue: 4
Pages: e35572
Publication
First Author: Jones RL
Year: 2018
Journal: Environ Health Perspect
Title: Use of a Mouse Model of Experimentally Induced Endometriosis to Evaluate and Compare the Effects of Bisphenol A and Bisphenol AF Exposure.
Volume: 126
Issue: 12
Pages: 127004
Publication
First Author: Mrass P
Year: 2017
Journal: Nat Commun
Title: ROCK regulates the intermittent mode of interstitial T cell migration in inflamed lungs.
Volume: 8
Issue: 1
Pages: 1010
Publication
First Author: Berretta F
Year: 2011
Journal: J Immunol
Title: IL-2 contributes to maintaining a balance between CD4+Foxp3+ regulatory T cells and effector CD4+ T cells required for immune control of blood-stage malaria infection.
Volume: 186
Issue: 8
Pages: 4862-71
Publication
First Author: Yurchenko E
Year: 2007
Journal: Transgenic Res
Title: Ubiquitous expression of mRFP-1 in vivo by site-directed transgenesis.
Volume: 16
Issue: 1
Pages: 29-40
Publication
First Author: Fee D
Year: 2003
Journal: J Neuroimmunol
Title: Activated/effector CD4+ T cells exacerbate acute damage in the central nervous system following traumatic injury.
Volume: 136
Issue: 1-2
Pages: 54-66
Publication
First Author: Ashpole NM
Year: 2014
Journal: Am J Physiol Heart Circ Physiol
Title: Systemic influences contribute to prolonged microvascular rarefaction after brain irradiation: a role for endothelial progenitor cells.
Volume: 307
Issue: 6
Pages: H858-68
Publication
First Author: Okano J
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Epidermis-dermis junction as a novel location for bone marrow-derived cells to reside in response to ionizing radiation.
Volume: 461
Issue: 4
Pages: 695-701
Publication
First Author: Piras BA
Year: 2013
Journal: PLoS One
Title: Systemic delivery of shRNA by AAV9 provides highly efficient knockdown of ubiquitously expressed GFP in mouse heart, but not liver.
Volume: 8
Issue: 9
Pages: e75894
Publication
First Author: Stewart KS
Year: 2011
Journal: Blood
Title: Delta-like ligand 4-Notch signaling regulates bone marrow-derived pericyte/vascular smooth muscle cell formation.
Volume: 117
Issue: 2
Pages: 719-26
Publication
First Author: Katagi M
Year: 2014
Journal: FEBS Lett
Title: Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy.
Volume: 588
Issue: 6
Pages: 1080-6
Publication
First Author: Baligar P
Year: 2016
Journal: Stem Cells
Title: Molecular and Cellular Functions Distinguish Superior Therapeutic Efficiency of Bone Marrow CD45 Cells Over Mesenchymal Stem Cells in Liver Cirrhosis.
Volume: 34
Issue: 1
Pages: 135-47
Publication
First Author: Metcalf D
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Multipotential hematopoietic blast colony-forming cells exhibit delays in self-generation and lineage commitment.
Volume: 107
Issue: 37
Pages: 16257-61
Publication
First Author: Chamoto K
Year: 2012
Journal: Am J Respir Cell Mol Biol
Title: CD34+ progenitor to endothelial cell transition in post-pneumonectomy angiogenesis.
Volume: 46
Issue: 3
Pages: 283-9
Strain
Attribute String: congenic, mutant strain, transgenic
Allele
Name: transgene insertion 28, Fabrizio G Mastronardi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 640, Universitatsspital Zurich
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 72, Peter 't Hoen
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: immunoglobulin heavy chain complex; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
Allele
Name: immunoglobulin heavy chain complex; targeted mutation 2, Velocigene
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
Allele
Name: immunoglobulin heavy chain complex; targeted mutation 3.1, Velocigene
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
Allele
Name: transgene insertion, Robin JM Franklin
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
Allele
Name: immunoglobulin heavy chain complex; targeted mutation 3, Velocigene
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
Publication
First Author: Cao Y
Year: 2006
Journal: Eur J Immunol
Title: Induction of experimental autoimmune encephalomyelitis in transgenic mice expressing ovalbumin in oligodendrocytes.
Volume: 36
Issue: 1
Pages: 207-15
Genotype
Symbol: Mbp/Mbp
Background: involves: C3H/HeJ * C57BL/6J * MDB/Dt
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Igh/Igh
Background: involves: 129S6/SvEvTac * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Igh/Igh
Background: involves: 129S6/SvEvTac * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(TPO-cre)1Shk/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Publication  
First Author: Kragh CL
Year: 2014
Journal: Neurobiol Dis
Title: Prodegenerative IκBα expression in oligodendroglial α-synuclein models of multiple system atrophy.
Volume: 63
Pages: 171-83
Publication
First Author: Shen AL
Year: 2010
Journal: PLoS One
Title: The PPCD1 mouse: characterization of a mouse model for posterior polymorphous corneal dystrophy and identification of a candidate gene.
Volume: 5
Issue: 8
Pages: e12213
Protein Domain
Type: Domain
Description: Myelin regulatory factor (Myrf) is a transcription regulator required in vertebrates for expression of central nervous system (CNS) myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and CNS myelination []. It is also required for the maintenance of expression of myelin genes and the mature oligodendrocytes identity in the adult CNS [, ]. A Caenorhabditis elegans orthologue, pqn-47, may function as a regulator of molting [], while a Dictyostelium orthologue has been described to regulate prestalk differentiation [].This domain is found towards the C terminus of myelin regulatory factor (Myrf) and corresponds to the Intramolecular Chaperone Auto-processing (ICA) domain. It forms a homo-trimer and carries out the auto-cleavage of Myrf releasing the N-terminal homo-trimer from the ER membrane. This allows its entry to the nucleus to function as a homo-trimer transcription factor [].
Publication
First Author: Oliver PM
Year: 2006
Journal: Immunity
Title: Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation.
Volume: 25
Issue: 6
Pages: 929-40
Strain
Attribute String: congenic, targeted mutation, transgenic
Publication
First Author: Mishra A
Year: 2017
Journal: Biol Open
Title: A novel immunodeficient NOD.SCID-rd1 mouse model of retinitis pigmentosa to investigate potential therapeutics and pathogenesis of retinal degeneration.
Volume: 6
Issue: 4
Pages: 449-462
Publication
First Author: Dai M
Year: 2010
Journal: Am J Pathol
Title: Bone marrow cell recruitment mediated by inducible nitric oxide synthase/stromal cell-derived factor-1alpha signaling repairs the acoustically damaged cochlear blood-labyrinth barrier.
Volume: 177
Issue: 6
Pages: 3089-99
Publication
First Author: Yurchenko E
Year: 2011
Journal: Eur J Immunol
Title: CD4+ Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammation.
Volume: 41
Issue: 12
Pages: 3455-66
Publication
First Author: Ilievski V
Year: 2015
Journal: PLoS One
Title: TLR4 Expression by Liver Resident Cells Mediates the Development of Glucose Intolerance and Insulin Resistance in Experimental Periodontitis.
Volume: 10
Issue: 8
Pages: e0136502
Publication
First Author: Rydström A
Year: 2023
Journal: Stem Cell Reports
Title: MAC-1 marks a quiescent and functionally superior HSC subset during regeneration.
Volume: 18
Issue: 3
Pages: 736-748
Publication
First Author: Nguyen V
Year: 2012
Journal: J Immunol
Title: IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms.
Volume: 189
Issue: 2
Pages: 1081-93
Publication
First Author: Claus C
Year: 2012
Journal: Cancer Res
Title: CD27 signaling increases the frequency of regulatory T cells and promotes tumor growth.
Volume: 72
Issue: 14
Pages: 3664-76
Publication
First Author: Faltusová K
Year: 2018
Journal: Stem Cells
Title: Stem Cell Defect in Ubiquitin-Green Fluorescent Protein Mice Facilitates Engraftment of Lymphoid-Primed Hematopoietic Stem Cells.
Volume: 36
Issue: 8
Pages: 1237-1248
Publication
First Author: Cui H
Year: 2016
Journal: Oncotarget
Title: Heparanase expression upregulates platelet adhesion activity and thrombogenicity.
Volume: 7
Issue: 26
Pages: 39486-39496
Publication
First Author: Jiang L
Year: 2020
Journal: Cell
Title: Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.
Volume: 183
Issue: 5
Pages: 1219-1233.e18