Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6304342 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3549820 |
Pattern: |
Not Specified |
Stage: |
TS20 |
Assay Id: |
MGI:6304429 |
Age: |
embryonic day 12.5 |
|
Note: |
Coexpressed with Fn1 in endothelial cells. |
Specimen Label: |
2a |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Allele |
Name: |
notch 1; targeted mutation 2, Raphael Kopan |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
fibronectin 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6304342 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1914327 |
Pattern: |
Regionally restricted |
Stage: |
TS27 |
Assay Id: |
MGI:6304429 |
Age: |
postnatal day 2 |
|
Note: |
Expression spred to the haematopoietic compartments. Co-expressed with Fn1 in sinus endothelial cells. |
Specimen Label: |
6b |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6304342 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1720326 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6304429 |
Age: |
embryonic day 18.5 |
|
Note: |
Decreased expression. Few areas of Vcam1 and Fn1 co-expressed were seen. |
Specimen Label: |
2b |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6304342 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3549826 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6304429 |
Age: |
embryonic day 18.5 |
|
Note: |
Decreased expression. Few areas of Vcam1 and Fn1 co-expressed were seen. Expressed in endothelial cells. |
Specimen Label: |
2b |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6304342 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2019-05-21 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3753928 |
Pattern: |
Regionally restricted |
Stage: |
TS28 |
Assay Id: |
MGI:6304429 |
Age: |
postnatal day 4 |
|
Note: |
Coexpression with Fn1 increased markedly on the surface layers of trabecular bone. |
Specimen Label: |
6c |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Allele |
Name: |
fibronectin 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 41, Susumu Tonegawa |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
160
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Bennett WF |
Year: |
1991 |
Journal: |
J Biol Chem |
Title: |
High resolution analysis of functional determinants on human tissue-type plasminogen activator. |
Volume: |
266 |
Issue: |
8 |
Pages: |
5191-201 |
|
•
•
•
•
•
|
Publication |
First Author: |
Downing AK |
Year: |
1992 |
Journal: |
J Mol Biol |
Title: |
Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance. |
Volume: |
225 |
Issue: |
3 |
Pages: |
821-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baron M |
Year: |
1990 |
Journal: |
Nature |
Title: |
Structure of the fibronectin type 1 module. |
Volume: |
345 |
Issue: |
6276 |
Pages: |
642-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Smith BO |
Year: |
1995 |
Journal: |
Structure |
Title: |
The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator. |
Volume: |
3 |
Issue: |
8 |
Pages: |
823-33 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
Fibronectin type I repeats are one of the three repeats found in the fibronectin protein.Fibronectin is a plasma protein that binds cell surfaces and various compoundsincluding collagen, fibrin, heparin, DNA, and actin. Type I domain (FN1) is approximately40 residues in length. Four conserved cysteines are involved in disulphide bonds. The 3Dstructure of the FN1 domain has been determined [, , ]. It consists of two antiparallelβ-sheets, first a double-stranded one, that is linked by a disulphide bond to atriple-stranded β-sheet. The second conserved disulphide bridge links the C-terminaladjacent strands of the domain.In human tissue plasminogen activator chain A the FN1 domain together with thefollowing epidermal growth factor (EGF)-like domain are involved infibrin-binding []. It has been suggested that these two modules form a single structuraland functional unit []. The two domains keep their specific tertiary structure, but interactintimately to bury a hydrophobic core; the inter-module linker makes up the third strand ofthe EGF-module's major β-sheet. |
|
•
•
•
•
•
|
Publication |
First Author: |
Kramer JM |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor. |
Volume: |
179 |
Issue: |
10 |
Pages: |
6379-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Monteith AJ |
Year: |
2021 |
Journal: |
Sci Adv |
Title: |
Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens. |
Volume: |
7 |
Issue: |
37 |
Pages: |
eabj2101 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pace JA |
Year: |
2021 |
Journal: |
Sci Adv |
Title: |
Podocyte-specific KLF4 is required to maintain parietal epithelial cell quiescence in the kidney. |
Volume: |
7 |
Issue: |
36 |
Pages: |
eabg6600 |
|
•
•
•
•
•
|
Publication |
First Author: |
Montgomery GW |
Year: |
1995 |
Journal: |
Anim Genet |
Title: |
Sheep linkage mapping: RFLP markers for comparative mapping studies. |
Volume: |
26 |
Issue: |
4 |
Pages: |
249-59 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Tissue-type plasminogen activator is a serine peptidase belonging to MEROPS peptidase family S1 (chymotrypsin family, clan PA(S)), subfamily S1A.The fibrinolytic system is the mechanism by which blood clots are dissolved via the plasmin-mediated degradation of fibrin into soluble end products. The system is activated by urokinase-type plasminogen activator (uPA; ) or by tissue-type plasminogen activator (tPA; ; this family), which are enzymes that convert the inactive proenzyme plasminogen to the active protease plasmin [].tPA is mainly involved in the activation of circulating plasminogen, while uPA activates cell-bound plasminogen after binding to a specific uPA receptor (uPAR).Following the signal sequence and propeptide regions, tPA typically contains a fibronectin type I (FN1) domain, an EGF-type domain, two kringle domains and a trypsin domain. However, there are members missing FN1 or EGF or one of the kringles.This entry also includes salivary plaminogen activators from the vampire bat (Desmodus rotundus). |
|
•
•
•
•
•
|
Publication |
First Author: |
Roy DS |
Year: |
2017 |
Journal: |
Cell |
Title: |
Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories. |
Volume: |
170 |
Issue: |
5 |
Pages: |
1000-1012.e19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Möckel T |
Year: |
2023 |
Journal: |
PLoS One |
Title: |
Transcriptome analysis of renal ischemia/reperfusion (I/R) injury in BAFF and BAFF-R deficient mice. |
Volume: |
18 |
Issue: |
9 |
Pages: |
e0291619 |
|
•
•
•
•
•
|
Publication |
First Author: |
Asher JH Jr |
Year: |
1990 |
Journal: |
J Med Genet |
Title: |
Mouse and hamster mutants as models for Waardenburg syndromes in humans. |
Volume: |
27 |
Issue: |
10 |
Pages: |
618-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matthaei M |
Year: |
2012 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy. |
Volume: |
53 |
Issue: |
10 |
Pages: |
6718-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu K |
Year: |
2017 |
Journal: |
Matrix Biol |
Title: |
Cell autonomous ANTXR1-mediated regulation of extracellular matrix components in primary fibroblasts. |
Volume: |
62 |
|
Pages: |
105-114 |
|
•
•
•
•
•
|
Publication |
First Author: |
Montgomery TA |
Year: |
2017 |
Journal: |
J Am Soc Nephrol |
Title: |
Breast Regression Protein-39/Chitinase 3-Like 1 Promotes Renal Fibrosis after Kidney Injury via Activation of Myofibroblasts. |
Volume: |
28 |
Issue: |
11 |
Pages: |
3218-3226 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beever JE |
Year: |
1994 |
Journal: |
Mamm Genome |
Title: |
A genetic map of nine loci on bovine chromosome 2. |
Volume: |
5 |
Issue: |
9 |
Pages: |
542-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lijnen HR |
Year: |
2001 |
Journal: |
Ann N Y Acad Sci |
Title: |
Elements of the fibrinolytic system. |
Volume: |
936 |
|
Pages: |
226-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang D |
Year: |
2023 |
Journal: |
Exp Neurol |
Title: |
Evidence that enolase-phosphatase 1 exacerbates early cerebral ischemia injury and blood-brain barrier breakdown by enhancing extracellular matrix destruction and inhibiting the interaction between ADI1 and MT1-MMP. |
Volume: |
365 |
|
Pages: |
114410 |
|
•
•
•
•
•
|
Publication |
First Author: |
McDaniel K |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury. |
Volume: |
292 |
Issue: |
27 |
Pages: |
11336-11347 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mao M |
Year: |
2021 |
Journal: |
Dis Model Mech |
Title: |
Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome. |
Volume: |
14 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1055
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1920
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
810
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2477
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2266
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2176
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2271
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1331
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2386
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2386
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2266
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2296
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2296
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1832
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2361
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
559
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
653
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
597
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
653
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
653
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
653
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
|
•
•
•
•
•
|