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Search results 101 to 120 out of 120 for Pan3

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0.018s

Type

Details

Score

Allele

Pan3<em1(IMPC)Tcp> | MGI:6367973

Name:	PAN3 poly(A) specific ribonuclease subunit; endonuclease-mediated mutation 1, The Centre for Phenogenomics
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

•

Allele

Pan3<Gt(IST14631F4)Tigm> | MGI:5245917

Name:	PAN3 poly(A) specific ribonuclease subunit; gene trap IST14631F4, Texas A&M Institute for Genomic Medicine
Allele Type:	Gene trapped

•

Allele

Pan3<Gt(IST15091A10)Tigm> | MGI:5277769

Name:	PAN3 poly(A) specific ribonuclease subunit; gene trap IST15091A10, Texas A&M Institute for Genomic Medicine
Allele Type:	Gene trapped

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Strain

MGI:6440121 | B6;129S5-Pan3<Gt(OST65480)Lex>/Tac

Attribute String:

mutant stock, gene trap

•

Allele

Pan3<Gt(A045F04)Wrst> | MGI:4335542

Name:	PAN3 poly(A) specific ribonuclease subunit; gene trap A045F04, German Gene Trap Consortium
Allele Type:	Gene trapped

•

Strain

MGI:6866526 | C57BL/6NCrl-Pan3<em1(IMPC)Tcp>/TcpMmucd

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

•

Strain

MGI:6492512 | C57BL/6N-Pan3<em1(IMPC)Tcp>/Tcp

Attribute String:

coisogenic, targeted mutation

•

Genotype

Symbol:	Pan3/Pan3
Background:	C57BL/6N-Pan3/Tcp
Zygosity:	hm
Has Mutant Allele:	true

•

Protein Coding Gene

MGI:1353431 | Pcsk1n

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Genotype

Symbol:	Pan3/Pan3<+>
Background:	C57BL/6N-Pan3/Tcp
Zygosity:	ht
Has Mutant Allele:	true

•

Publication

32905781 | -

First Author:	Liu J
Year:	2020
Journal:	Cell Rep
Title:	YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.
Volume:	32
Issue:	10
Pages:	108120

•

Publication

30643264 | J:282657

First Author:	Zhu P
Year:	2019
Journal:	Nat Immunol
Title:	IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3.
Volume:	20
Issue:	2
Pages:	183-194

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Publication

24880344 | -

First Author:	Schäfer IB
Year:	2014
Journal:	Nat Struct Mol Biol
Title:	The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase.
Volume:	21
Issue:	7
Pages:	591-8

•

Protein Domain

IPR028881 | PAN2_UCH_dom

Type:

Domain

Description:

The poly(A)-specific nuclease (PAN) is a deadenylating enzyme involved in cytoplasmic mRNA turnover and consists of two subunits, PAN2 and PAN3, which form a conserved complex acting in the initial trimming of poly(A) tails, a process followed by the processive action of CCR4-NOT complex. PAN2 is the catalytic subunit and has two independent structural units, the N-terminal assembly unit which engages in a bipartite interaction with PAN3 dimers and the C-terminal catalytic unit [, , ]. The C-terminal unit contains the ubiquitin C-terminal hydrolase (UCH) domain, represented in this entry, and a RNase domain of the DEDD superfamily () [, ].

•

Protein Domain

IPR030843 | PAN2

Type:

Family

Description:

Pan2 is a catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of the two eukaryotic poly(A) nuclease complexes (Ccr4-Caf1 and Pan2-Pan3) involved in mRNA decay [, ]. Pan2 is involved in the initial stage of deadenylation of mRNA, which is required for poly(A) tail shortening []. Regulation of mRNA decay rates in eukaryotic cells affects gene expression []. The Pan2-Pan3 complex shortens cytoplasmic mRNA 3' polyA tails to regulate mRNA stability []. In the complex Pan2 provides the catalytic activity, whereas Pan3 mediates Pan2 recruitment tomRNA targets [].

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Protein

Q8BGF7

Organism:	Mus musculus/domesticus
Length:	1200
Fragment?:	false

•

Protein

Q80XN5

Organism:	Mus musculus/domesticus
Length:	424
Fragment?:	false

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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