Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Rev1 is a deoxycytidyl transferase involved in translesion DNA synthesis (TLS) pathway to bypass DNA lesions during replication []. During TLS, Y-family DNA polymerase (Poleta, Polkappa, Poliota and Rev1) incorporates a nucleotide opposite the DNA lesion, and then Polzeta (consitst of Rev3 and Rev7) carries out primer extension. Rev1 is a unique member of the Y polymerase family, since its catalytic activity is limited to DNA-dependent, deoxycytidyl transferase activity [, , ]. |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Masuda Y |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Mechanisms of dCMP transferase reactions catalyzed by mouse Rev1 protein. |
Volume: |
277 |
Issue: |
4 |
Pages: |
3040-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nelson JR |
Year: |
1996 |
Journal: |
Nature |
Title: |
Deoxycytidyl transferase activity of yeast REV1 protein. |
Volume: |
382 |
Issue: |
6593 |
Pages: |
729-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masuda Y |
Year: |
2001 |
Journal: |
J Biol Chem |
Title: |
Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain. |
Volume: |
276 |
Issue: |
18 |
Pages: |
15051-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1249
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie W |
Year: |
2012 |
Journal: |
Protein Cell |
Title: |
Structural insights into the assembly of human translesion polymerase complexes. |
Volume: |
3 |
Issue: |
11 |
Pages: |
864-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo C |
Year: |
2003 |
Journal: |
EMBO J |
Title: |
Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. |
Volume: |
22 |
Issue: |
24 |
Pages: |
6621-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim H |
Year: |
2012 |
Journal: |
Nat Struct Mol Biol |
Title: |
Regulation of Rev1 by the Fanconi anemia core complex. |
Volume: |
19 |
Issue: |
2 |
Pages: |
164-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dumstorf CA |
Year: |
2009 |
Journal: |
Mol Cancer Res |
Title: |
REV1 is implicated in the development of carcinogen-induced lung cancer. |
Volume: |
7 |
Issue: |
2 |
Pages: |
247-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Poltoratsky VP |
Year: |
2000 |
Journal: |
GenBank Submission |
Title: |
Mus musculus REV1 protein (Rev1) mRNA, complete cds |
|
|
Pages: |
AF179302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo C |
Year: |
2006 |
Journal: |
Mol Cell |
Title: |
REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo. |
Volume: |
23 |
Issue: |
2 |
Pages: |
265-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jansen JG |
Year: |
2005 |
Journal: |
Nucleic Acids Res |
Title: |
The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis. |
Volume: |
33 |
Issue: |
1 |
Pages: |
356-65 |
|
•
•
•
•
•
|
Publication |
First Author: |
Prasad R |
Year: |
2016 |
Journal: |
Nucleic Acids Res |
Title: |
Rev1 is a base excision repair enzyme with 5'-deoxyribose phosphate lyase activity. |
Volume: |
44 |
Issue: |
22 |
Pages: |
10824-10833 |
|
•
•
•
•
•
|
Publication |
First Author: |
In Het Panhuis W |
Year: |
2022 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Rev1 deficiency induces replication stress to cause metabolic dysfunction differently in males and females. |
Volume: |
322 |
Issue: |
3 |
Pages: |
E319-E329 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wojtaszek J |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Multifaceted recognition of vertebrate Rev1 by translesion polymerases ζ and κ. |
Volume: |
287 |
Issue: |
31 |
Pages: |
26400-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo C |
Year: |
2006 |
Journal: |
Mol Cell Biol |
Title: |
Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. |
Volume: |
26 |
Issue: |
23 |
Pages: |
8892-900 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sasatani M |
Year: |
2017 |
Journal: |
Carcinogenesis |
Title: |
Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level. |
Volume: |
38 |
Issue: |
5 |
Pages: |
570-578 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fakouri NB |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis. |
Volume: |
7 |
Issue: |
1 |
Pages: |
12480 |
|
•
•
•
•
•
|
Publication |
First Author: |
Masuda K |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
A critical role for REV1 in regulating the induction of C:G transitions and A:T mutations during Ig gene hypermutation. |
Volume: |
183 |
Issue: |
3 |
Pages: |
1846-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoon JH |
Year: |
2015 |
Journal: |
Genes Dev |
Title: |
Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ. |
Volume: |
29 |
Issue: |
24 |
Pages: |
2588-602 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zan H |
Year: |
2012 |
Journal: |
Cell Rep |
Title: |
Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination. |
Volume: |
2 |
Issue: |
5 |
Pages: |
1220-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jansen JG |
Year: |
2009 |
Journal: |
Mol Cell Biol |
Title: |
Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells. |
Volume: |
29 |
Issue: |
11 |
Pages: |
3113-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krijger PH |
Year: |
2013 |
Journal: |
Eur J Immunol |
Title: |
Rev1 is essential in generating G to C transversions downstream of the Ung2 pathway but not the Msh2+Ung2 hybrid pathway. |
Volume: |
43 |
Issue: |
10 |
Pages: |
2765-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kano C |
Year: |
2012 |
Journal: |
Int Immunol |
Title: |
Analysis of mice deficient in both REV1 catalytic activity and POLH reveals an unexpected role for POLH in the generation of C to G and G to C transversions during Ig gene hypermutation. |
Volume: |
24 |
Issue: |
3 |
Pages: |
169-74 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jansen JG |
Year: |
2006 |
Journal: |
J Exp Med |
Title: |
Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice. |
Volume: |
203 |
Issue: |
2 |
Pages: |
319-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Martín-Pardillos A |
Year: |
2017 |
Journal: |
Blood |
Title: |
Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions. |
Volume: |
130 |
Issue: |
13 |
Pages: |
1523-1534 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lv L |
Year: |
2013 |
Journal: |
Nucleic Acids Res |
Title: |
Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation. |
Volume: |
41 |
Issue: |
22 |
Pages: |
10312-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Enoiu M |
Year: |
2012 |
Journal: |
Nucleic Acids Res |
Title: |
Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis. |
Volume: |
40 |
Issue: |
18 |
Pages: |
8953-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ito W |
Year: |
2012 |
Journal: |
Genes Cells |
Title: |
Stalled Polη at its cognate substrate initiates an alternative translesion synthesis pathway via interaction with REV1. |
Volume: |
17 |
Issue: |
2 |
Pages: |
98-108 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Tsaalbi-Shtylik A |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia. |
Volume: |
106 |
Issue: |
51 |
Pages: |
21836-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shah P |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
Primordial germ cell DNA demethylation and development require DNA translesion synthesis. |
Volume: |
15 |
Issue: |
1 |
Pages: |
3734 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oberbeck N |
Year: |
2014 |
Journal: |
Mol Cell |
Title: |
Maternal aldehyde elimination during pregnancy preserves the fetal genome. |
Volume: |
55 |
Issue: |
6 |
Pages: |
807-817 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakahara M |
Year: |
2013 |
Journal: |
Mamm Genome |
Title: |
Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. |
Volume: |
24 |
Issue: |
5-6 |
Pages: |
228-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Araki K |
Year: |
1999 |
Journal: |
Cell Mol Biol (Noisy-le-grand) |
Title: |
Exchangeable gene trap using the Cre/mutated lox system. |
Volume: |
45 |
Issue: |
5 |
Pages: |
737-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taniwaki T |
Year: |
2005 |
Journal: |
Dev Growth Differ |
Title: |
Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. |
Volume: |
47 |
Issue: |
3 |
Pages: |
163-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
RIKEN Data Curation in Mouse Genome Informatics |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ko MS |
Year: |
2000 |
Journal: |
Development |
Title: |
Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. |
Volume: |
127 |
Issue: |
8 |
Pages: |
1737-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
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•
•
•
•
•
|
Publication |
First Author: |
Friedel RH |
Year: |
2007 |
Journal: |
Brief Funct Genomic Proteomic |
Title: |
EUCOMM--the European conditional mouse mutagenesis program. |
Volume: |
6 |
Issue: |
3 |
Pages: |
180-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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•
•
•
•
•
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Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
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•
•
•
•
•
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Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
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Title: |
Cyagen Biosciences Website. |
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•
•
•
•
•
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Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
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•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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•
•
•
•
•
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Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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•
•
•
•
•
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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•
•
•
•
•
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Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
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•
•
•
•
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Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
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•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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•
•
•
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•
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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•
•
•
•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
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•
•
•
•
•
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Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
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•
•
•
•
•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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•
•
•
•
•
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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|
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•
•
•
•
•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
•
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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•
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•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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