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Search results 1401 to 1500 out of 2034 for Bcr

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Type Details Score
Publication
- | J:77216
   
First Author: Karpitskiy VV
Year: 1998
Journal: GenBank Submission
Title: Mus musculus 14-3-3 protein sigma mRNA, complete cds
Pages: AF058798
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Protein Coding Gene
MGI:2146320 | Dock10
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q6PAJ1
Organism: Mus musculus/domesticus
Length: 1270  
Fragment?: false
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Protein
A0A571BG95
Organism: Mus musculus/domesticus
Length: 1185  
Fragment?: false
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Protein Coding Gene
MGI:1889583 | Sh3kbp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Cd79a/Cd79a
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Cd19/Cd19<+>
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Protein
O70479
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
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Protein
Q922M3
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
Q8BGV7
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Protein
F8WGQ9
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
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Protein
A0JLP8
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Protein
S4R2A3
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Publication
8163536 | -
First Author: Law CL
Year: 1994
Journal: J Biol Chem
Title: Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex.
Volume: 269
Issue: 16
Pages: 12310-9
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Publication
1874735 | -
First Author: Taniguchi T
Year: 1991
Journal: J Biol Chem
Title: Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis.
Volume: 266
Issue: 24
Pages: 15790-6
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Publication
9551546 | -
First Author: Barford D
Year: 1998
Journal: Structure
Title: Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2.
Volume: 6
Issue: 3
Pages: 249-54
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Protein Domain
IPR012234 | Tyr_kinase_non-rcpt_SYK/ZAP70
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].This entry represents the non-receptor tyrosine kinases SYK and ZAP-70 [, , ]:SYK is a positive effector of BCR-stimulated responses. It couples the B-cell antigen receptor (BCR) to the mobilisation of calcium ion, either through a phosphoinositide 3-kinase-dependent pathway (when not phosphorylated on tyrosines of the linker region), or through a phospholipase C-gamma-dependent pathway (when phosphorylated on Tyr-342 and Tyr-346). Therefore, the differential phosphorylation of Syk can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ion [, ].ZAP70 plays a role in T-cell development and lymphocyte activation. It is essential for TCR-mediated IL-2 production. Isoform 1 of ZAP70 induces TCR-mediated signal transduction, isoform 2 does not [, ].
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Publication
26041538 | J:322367
First Author: Tartey S
Year: 2015
Journal: J Immunol
Title: Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses.
Volume: 195
Issue: 2
Pages: 519-27
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Publication
16301621 | J:108677
First Author: Coughlin JJ
Year: 2005
Journal: J Immunol
Title: RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling.
Volume: 175
Issue: 11
Pages: 7179-84
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Publication
16263223 | J:103474
 
First Author: Masuda K
Year: 2005
Journal: Gene
Title: FcRY, an Fc receptor related gene differentially expressed during B lymphocyte development and activation.
Volume: 363
Pages: 32-40
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Publication
8168489 | J:17868
First Author: Clark MR
Year: 1994
Journal: EMBO J
Title: Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity.
Volume: 13
Issue: 8
Pages: 1911-9
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Publication
10587346 | J:124758
First Author: Cheng PC
Year: 1999
Journal: J Exp Med
Title: A role for lipid rafts in B cell antigen receptor signaling and antigen targeting.
Volume: 190
Issue: 11
Pages: 1549-60
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Publication
11238609 | J:124754
First Author: Cheng PC
Year: 2001
Journal: J Immunol
Title: Translocation of the B cell antigen receptor into lipid rafts reveals a novel step in signaling.
Volume: 166
Issue: 6
Pages: 3693-701
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Publication
15661879 | J:96419
First Author: Fuentes-Pananá EM
Year: 2005
Journal: J Immunol
Title: Ig alpha/Ig beta complexes generate signals for B cell development independent of selective plasma membrane compartmentalization.
Volume: 174
Issue: 3
Pages: 1245-52
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Publication
10748054 | J:113920
First Author: Poe JC
Year: 2000
Journal: J Biol Chem
Title: CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
Volume: 275
Issue: 23
Pages: 17420-7
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Publication
8464478 | J:4309
First Author: Miki T
Year: 1993
Journal: Nature
Title: Oncogene ect2 is related to regulators of small GTP-binding proteins.
Volume: 362
Issue: 6419
Pages: 462-5
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Publication
29288206 | J:258123
First Author: Bod L
Year: 2018
Journal: J Immunol
Title: IL-4-Induced Gene 1: A Negative Immune Checkpoint Controlling B Cell Differentiation and Activation.
Volume: 200
Issue: 3
Pages: 1027-1038
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Publication
16166635 | J:101363
First Author: Kroll J
Year: 2005
Journal: Mol Cell Biol
Title: The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation.
Volume: 25
Issue: 19
Pages: 8531-40
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Publication
17640867 | J:124931
First Author: Chew V
Year: 2007
Journal: J Biol Chem
Title: Leupaxin negatively regulates B cell receptor signaling.
Volume: 282
Issue: 37
Pages: 27181-91
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Publication
7584145 | J:29751
First Author: Nishizumi H
Year: 1995
Journal: Immunity
Title: Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice.
Volume: 3
Issue: 5
Pages: 549-60
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Publication
12486102 | J:110913
First Author: Hibbs ML
Year: 2002
Journal: J Exp Med
Title: Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity.
Volume: 196
Issue: 12
Pages: 1593-604
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Publication
15749887 | J:97708
First Author: Mielenz D
Year: 2005
Journal: J Immunol
Title: Lipid rafts associate with intracellular B cell receptors and exhibit a B cell stage-specific protein composition.
Volume: 174
Issue: 6
Pages: 3508-17
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Publication
10770799 | J:61724
First Author: Marshall AJ
Year: 2000
Journal: J Exp Med
Title: A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase.
Volume: 191
Issue: 8
Pages: 1319-32
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Publication
18559951 | J:138146
First Author: Liu Y
Year: 2008
Journal: J Leukoc Biol
Title: Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.
Volume: 84
Issue: 3
Pages: 842-51
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Publication
20101619 | J:159193
First Author: Ishiura N
Year: 2010
Journal: Eur J Immunol
Title: Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation.
Volume: 40
Issue: 4
Pages: 1192-204
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Publication
16129705 | J:100706
First Author: Xing Y
Year: 2005
Journal: J Exp Med
Title: Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis.
Volume: 202
Issue: 5
Pages: 707-19
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Publication
25801429 | J:244548
First Author: Wong EB
Year: 2015
Journal: J Immunol
Title: B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance.
Volume: 194
Issue: 9
Pages: 4130-43
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Publication
19923443 | J:158032
First Author: Wang D
Year: 2010
Journal: FASEB J
Title: Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1.
Volume: 24
Issue: 3
Pages: 947-56
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Publication
20956287 | J:166239
First Author: Browne CD
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: SHEP1 partners with CasL to promote marginal zone B-cell maturation.
Volume: 107
Issue: 44
Pages: 18944-9
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Publication
23836061 | J:205703
First Author: Pfrengle F
Year: 2013
Journal: J Immunol
Title: Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.
Volume: 191
Issue: 4
Pages: 1724-31
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Publication
24790146 | J:265415
First Author: Hutzler S
Year: 2014
Journal: J Immunol
Title: The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells.
Volume: 192
Issue: 11
Pages: 5406-14
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Publication
24907343 | J:232061
First Author: Hartweger H
Year: 2014
Journal: J Immunol
Title: Themis2 is not required for B cell development, activation, and antibody responses.
Volume: 193
Issue: 2
Pages: 700-7
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Publication
22048769 | J:179699
First Author: Basu S
Year: 2011
Journal: J Immunol
Title: Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses.
Volume: 187
Issue: 11
Pages: 5720-32
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Publication
20519653 | J:161622
First Author: Ouchida R
Year: 2010
Journal: J Immunol
Title: A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation.
Volume: 185
Issue: 1
Pages: 294-301
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Publication
17207856 | J:118704
First Author: Contreras CM
Year: 2007
Journal: Mol Immunol
Title: Btk regulates multiple stages in the development and survival of B-1 cells.
Volume: 44
Issue: 10
Pages: 2719-28
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Publication
22327079 | J:181844
First Author: Chatterjee P
Year: 2012
Journal: J Immunol
Title: Modulation of antigen presentation and B cell receptor signaling in B cells of beige mice.
Volume: 188
Issue: 6
Pages: 2695-702
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Publication
9254656 | J:42368
First Author: Pani G
Year: 1997
Journal: J Exp Med
Title: The motheaten mutation rescues B cell signaling and development in CD45-deficient mice.
Volume: 186
Issue: 4
Pages: 581-8
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Publication
19380785 | J:150309
First Author: Gross AJ
Year: 2009
Journal: J Immunol
Title: Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance.
Volume: 182
Issue: 9
Pages: 5382-92
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Publication
23509253 | J:194234
First Author: Zhu Z
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling.
Volume: 110
Issue: 14
Pages: E1282-90
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Publication
21791431 | J:177075
First Author: Ma P
Year: 2011
Journal: Blood
Title: The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor.
Volume: 118
Issue: 13
Pages: 3459-69
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Publication
16530850 | J:144136
First Author: Coughlin JJ
Year: 2006
Journal: Immunol Lett
Title: The role of RasGRPs in regulation of lymphocyte proliferation.
Volume: 105
Issue: 1
Pages: 77-82
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Publication
15634889 | J:132847
First Author: Moll T
Year: 2005
Journal: J Immunol
Title: Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation.
Volume: 174
Issue: 2
Pages: 702-9
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Publication
18927440 | J:144568
First Author: Matsuda S
Year: 2009
Journal: Blood
Title: Critical role of class IA PI3K for c-Rel expression in B lymphocytes.
Volume: 113
Issue: 5
Pages: 1037-44
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Publication
15661902 | J:110016
First Author: Kanayama N
Year: 2005
Journal: J Immunol
Title: Analysis of marginal zone B cell development in the mouse with limited B cell diversity: role of the antigen receptor signals in the recruitment of B cells to the marginal zone.
Volume: 174
Issue: 3
Pages: 1438-45
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Publication
24223520 | J:205106
First Author: Liu C
Year: 2013
Journal: PLoS Biol
Title: N-wasp is essential for the negative regulation of B cell receptor signaling.
Volume: 11
Issue: 11
Pages: e1001704
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Publication
17082595 | J:140491
First Author: Won WJ
Year: 2006
Journal: J Immunol
Title: Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells.
Volume: 177
Issue: 10
Pages: 6815-23
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Publication
23378429 | J:193615
First Author: Crane DD
Year: 2013
Journal: J Immunol
Title: B1a cells enhance susceptibility to infection with virulent Francisella tularensis via modulation of NK/NKT cell responses.
Volume: 190
Issue: 6
Pages: 2756-66
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Publication
18354197 | J:133383
First Author: Schram BR
Year: 2008
Journal: J Immunol
Title: B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements.
Volume: 180
Issue: 7
Pages: 4728-41
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Publication
23804807 | J:209556
First Author: Nündel K
Year: 2013
Journal: J Leukoc Biol
Title: The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells.
Volume: 94
Issue: 5
Pages: 865-75
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Publication
15384044 | J:115457
First Author: Hess KL
Year: 2004
Journal: Eur J Immunol
Title: Frontline: The p85alpha isoform of phosphoinositide 3-kinase is essential for a subset of B cell receptor-initiated signaling responses.
Volume: 34
Issue: 11
Pages: 2968-76
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Publication
19841184 | J:157189
First Author: Kendall PL
Year: 2009
Journal: J Immunol
Title: Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene.
Volume: 183
Issue: 10
Pages: 6403-12
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Publication
17339472 | J:144277
First Author: Alugupalli KR
Year: 2007
Journal: J Immunol
Title: MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses.
Volume: 178
Issue: 6
Pages: 3740-9
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Publication
18641308 | J:137874
First Author: Kerfoot SM
Year: 2008
Journal: J Immunol
Title: Identification of initiator B cells, a novel subset of activation-induced deaminase-dependent B-1-like cells that mediate initiation of contact sensitivity.
Volume: 181
Issue: 3
Pages: 1717-27
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Publication
12055217 | J:123796
First Author: Lajaunias F
Year: 2002
Journal: J Immunol
Title: Differentially regulated expression and function of CD22 in activated B-1 and B-2 lymphocytes.
Volume: 168
Issue: 12
Pages: 6078-83
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Publication
11466342 | J:120492
First Author: Wu HJ
Year: 2001
Journal: J Immunol
Title: Positive signaling through CD72 induces mitogen-activated protein kinase activation and synergizes with B cell receptor signals to induce X-linked immunodeficiency B cell proliferation.
Volume: 167
Issue: 3
Pages: 1263-73
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Publication
16982884 | J:139321
First Author: Yan J
Year: 2006
Journal: J Immunol
Title: B cells drive early T cell autoimmunity in vivo prior to dendritic cell-mediated autoantigen presentation.
Volume: 177
Issue: 7
Pages: 4481-7
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Publication
12486097 | J:131138
First Author: Li Y
Year: 2002
Journal: J Exp Med
Title: Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern.
Volume: 196
Issue: 12
Pages: 1543-52
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Publication
22984080 | J:190650
First Author: Lee SR
Year: 2012
Journal: J Immunol
Title: Receptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells.
Volume: 189
Issue: 8
Pages: 3859-68
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Publication
23616572 | J:204782
First Author: Xu M
Year: 2013
Journal: J Immunol
Title: Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease.
Volume: 190
Issue: 11
Pages: 5436-45
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Publication
16116172 | J:113242
First Author: Barrington RA
Year: 2005
Journal: J Immunol
Title: CD21/CD19 coreceptor signaling promotes B cell survival during primary immune responses.
Volume: 175
Issue: 5
Pages: 2859-67
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Publication
23296704 | J:193016
First Author: Nickerson KM
Year: 2013
Journal: J Immunol
Title: TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation.
Volume: 190
Issue: 4
Pages: 1447-56
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Publication
15210829 | J:90963
First Author: Jin H
Year: 2004
Journal: J Immunol
Title: Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis.
Volume: 173
Issue: 1
Pages: 657-65
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Publication
31732528 | J:282189
First Author: Kulik L
Year: 2019
Journal: J Immunol
Title: Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus.
Volume: 203
Issue: 12
Pages: 3136-3147
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Publication
23365086 | J:193457
First Author: Oishi H
Year: 2013
Journal: J Immunol
Title: A bacterial artificial chromosome transgene with polymorphic Cd72 inhibits the development of glomerulonephritis and vasculitis in MRL-Faslpr lupus mice.
Volume: 190
Issue: 5
Pages: 2129-37
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Publication
10744653 | J:61691
First Author: Yoshida T
Year: 2000
Journal: Int Immunol
Title: Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice.
Volume: 12
Issue: 4
Pages: 517-26
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Publication
23979161 | J:201583
First Author: Hess C
Year: 2013
Journal: J Clin Invest
Title: T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies.
Volume: 123
Issue: 9
Pages: 3788-96
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Publication
21030983 | J:167638
First Author: Ta VB
Year: 2011
Journal: Leukemia
Title: Pre-B-cell leukemias in Btk/Slp65-deficient mice arise independently of ongoing V(D)J recombination activity.
Volume: 25
Issue: 1
Pages: 48-56
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Publication
19494297 | J:149292
First Author: Castro I
Year: 2009
Journal: J Immunol
Title: B cell receptor-mediated sustained c-Rel activation facilitates late transitional B cell survival through control of B cell activating factor receptor and NF-kappaB2.
Volume: 182
Issue: 12
Pages: 7729-37
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Publication
31534009 | J:280800
     
First Author: Nündel K
Year: 2019
Journal: J Immunol
Title: Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 Vκ8 B Cells.
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Publication
28368423 | J:248153
First Author: Moyo TK
Year: 2017
Journal: Oncogene
Title: Myc enhances B-cell receptor signaling in precancerous B cells and confers resistance to Btk inhibition.
Volume: 36
Issue: 32
Pages: 4653-4661
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Publication
17202334 | J:142634
First Author: Hinman RM
Year: 2007
Journal: J Immunol
Title: B cell receptor signaling down-regulates forkhead box transcription factor class O 1 mRNA expression via phosphatidylinositol 3-kinase and Bruton's tyrosine kinase.
Volume: 178
Issue: 2
Pages: 740-7
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Publication
29483358 | J:261314
First Author: Nyhoff LE
Year: 2018
Journal: J Immunol
Title: Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages.
Volume: 200
Issue: 7
Pages: 2352-2361
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Publication
9730885 | J:50288
First Author: Satterthwaite AB
Year: 1998
Journal: J Exp Med
Title: Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways.
Volume: 188
Issue: 5
Pages: 833-44
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Publication
17372989 | J:120843
First Author: Halcomb KE
Year: 2007
Journal: Eur J Immunol
Title: Btk and phospholipase C gamma 2 can function independently during B cell development.
Volume: 37
Issue: 4
Pages: 1033-42
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Publication
18849077 | J:141113
First Author: Halcomb KE
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