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Search results 101 to 200 out of 224 for Rnf114

0.021s
Type Details Score
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1778727
Stage: TS27
Assay Id: MGI:3508377
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754421
Stage: TS21
Assay Id: MGI:3508377
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754427
Stage: TS27
Assay Id: MGI:3508377
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1869223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9342
Specimen Label: GUDMAP:9342
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666821
Stage: TS21
Assay Id: MGI:3508377
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666827
Stage: TS27
Assay Id: MGI:3508377
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647021
Stage: TS21
Assay Id: MGI:3508377
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1647027
Stage: TS27
Assay Id: MGI:3508377
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1647017
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:3509657
Age: embryonic day 10.5
Image: 1
Note: Authors stated that in some instances they could not determine expression levels with certainty.
Specimen Label: 1
Specimen Num: 1
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1647016
Pattern: Not Specified
Stage: TS16
Assay Id: MGI:3509657
Age: embryonic day 10.5
Image: 2
Note: Authors stated that in some instances they could not determine expression levels with certainty.
Specimen Label: 2
Specimen Num: 2
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:3508377
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3185827
Stage: TS27
Assay Id: MGI:3508377
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9341
Specimen Label: GUDMAP:9341
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9342
Specimen Label: GUDMAP:9342
Detected: false
Specimen Num: 3
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1797223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9342
Specimen Label: GUDMAP:9342
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:5540230
Age: postnatal day 0
Image: GUDMAP:7228
Specimen Label: GUDMAP:7228
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1832123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9341
Specimen Label: GUDMAP:9341
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:1832123
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9342
Specimen Label: GUDMAP:9342
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9341
Specimen Label: GUDMAP:9341
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2851823
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9342
Specimen Label: GUDMAP:9342
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754021
Stage: TS21
Assay Id: MGI:3508377
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754027
Stage: TS27
Assay Id: MGI:3508377
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9341
Specimen Label: GUDMAP:9341
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2760523
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9342
Specimen Label: GUDMAP:9342
Detected: false
Specimen Num: 3
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280927
Stage: TS27
Assay Id: MGI:3508377
Age: postnatal newborn
Image: 2
Note: The tissue was olfactory epithelium and/or bulb.
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267921
Stage: TS21
Assay Id: MGI:3508377
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3267927
Stage: TS27
Assay Id: MGI:3508377
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9341
Specimen Label: GUDMAP:9341
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9342
Specimen Label: GUDMAP:9342
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2874723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9341
Specimen Label: GUDMAP:9341
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757721
Stage: TS21
Assay Id: MGI:3508377
Age: embryonic day 13.5
Image: 1
Specimen Label: 1
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2004-12-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757727
Stage: TS27
Assay Id: MGI:3508377
Age: postnatal newborn
Image: 2
Specimen Label: 2
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9341
Specimen Label: GUDMAP:9341
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3507310
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2850023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540230
Age: embryonic day 15.5
Image: GUDMAP:9342
Specimen Label: GUDMAP:9342
Detected: true
Specimen Num: 3
Publication    
First Author: Zhang S
Year: 2000
Journal: GenBank Submission
Title: Mus musculus Zfp228 (Znf228) mRNA, complete cds
Pages: AF282919
Publication  
First Author: Wu Y
Year: 2020
Journal: Front Cell Dev Biol
Title: Maternal UHRF1 Is Essential for Transcription Landscapes and Repression of Repetitive Elements During the Maternal-to-Zygotic Transition.
Volume: 8
Pages: 610773
Publication
First Author: Butterfield NC
Year: 2021
Journal: Nat Commun
Title: Accelerating functional gene discovery in osteoarthritis.
Volume: 12
Issue: 1
Pages: 467
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
Publication  
First Author: Wiese CB
Year: 2012
Journal: Front Neurosci
Title: A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.
Volume: 6
Pages: 130
Publication      
First Author: MGI and IMPC
Year: 2017
Journal: MGI Direct Data Submission
Title: MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
Publication
First Author: Guo G
Year: 2010
Journal: Dev Cell
Title: Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Volume: 18
Issue: 4
Pages: 675-85
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
UniProt Feature
Begin: 1
Description: E3 ubiquitin-protein ligase RNF114
Type: chain
End: 229
Protein
Organism: Mus musculus/domesticus
Length: 57  
Fragment?: false
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Yang P
Year: 2014
Journal: Immunobiology
Title: Identification of RNF114 as a novel positive regulatory protein for T cell activation.
Volume: 219
Issue: 6
Pages: 432-9
Publication  
First Author: Rodriguez MS
Year: 2014
Journal: Cell Death Dis
Title: The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation.
Volume: 5
Pages: e1399
Publication
First Author: Bijlmakers MJ
Year: 2011
Journal: Hum Mol Genet
Title: Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis.
Volume: 20
Issue: 16
Pages: 3129-37
Publication
First Author: Capon F
Year: 2008
Journal: Hum Mol Genet
Title: Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.
Volume: 17
Issue: 13
Pages: 1938-45
Protein Domain
Type: Domain
Description: RNF114 (also known as Znf313) is a p21(WAF1)-targeting ubiquitin E3 ligase that interacts with X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) and may play a role in p53-mediated cell-fate decisions [, ]. It is involved in immune response to double-stranded RNA in disease pathogenesis []. Moreover, RNF114 interacts with A20 and modulates its ubiquitination []. It negatively regulates nuclear factor-kappaB (NF-kappaB)-dependent transcription and positively regulates T-cell activation []. RNF114 may play a putative role in the regulation of immune responses, since it corresponds to a novel psoriasis susceptibility gene, ZNF313 []. RNF114, together with three closely related proteins: RNF125, RNF138 and RNF166, forms a novel family of ubiquitin ligases with a C3HC4-type RING-HC finger, a C2HC-, and two C2H2-type zinc fingers, as well as a ubiquitin interacting motif (UIM).
Publication
First Author: Wellner U
Year: 2009
Journal: Nat Cell Biol
Title: The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
Volume: 11
Issue: 12
Pages: 1487-95
Publication
First Author: Gosti F
Year: 1995
Journal: Mol Gen Genet
Title: Abscisic acid-dependent and -independent regulation of gene expression by progressive drought in Arabidopsis thaliana.
Volume: 246
Issue: 1
Pages: 10-8
Protein Domain
Type: Domain
Description: This zinc-binding domain is found in plant drought induced 19 (Di19) proteins, animal E3 ubiquitin-protein ligases (RNF114/KCMF1/RNF138/RNF125) and transcriptional repressors (ZEB1/ZEB2). Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought []. KCMF1 and RNF114 are E3 ubiquitin-protein ligases [, ], while ZEB1 represses transcription by binding to the E box (5'-CANNTG-3') [].
Publication
First Author: Lee MG
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.
Volume: 111
Issue: 43
Pages: 15532-7
Publication
First Author: Jang JH
Year: 2004
Journal: FEBS Lett
Title: FIGC, a novel FGF-induced ubiquitin-protein ligase in gastric cancers.
Volume: 578
Issue: 1-2
Pages: 21-5
Publication
First Author: Giannini AL
Year: 2008
Journal: Biochem J
Title: T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain.
Volume: 410
Issue: 1
Pages: 101-11
Publication
First Author: Han D
Year: 2016
Journal: PLoS One
Title: Ubiquitylation of Rad51d Mediated by E3 Ligase Rnf138 Promotes the Homologous Recombination Repair Pathway.
Volume: 11
Issue: 5
Pages: e0155476
Publication  
First Author: Chen HW
Year: 2015
Journal: Sci Rep
Title: Ring finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6.
Volume: 5
Pages: 14770
Protein Domain
Type: Domain
Description: This entry includes the C2HC RNF-type zinc finger.Ubiquitination is a post-translational modification that mediates the covalent attachment of ubiquitin (Ub), a small, highly conserved, cytoplasmic protein of 76 amino acid residues, to target proteins. This conjugation is catalyzed by the sequential action of three enzymes: Ub-activating (E1) enzyme, Ub-conjugating (E2) enzyme and Ub ligase (E3). A large number of RING finger (RNF) proteins are present in eukaryotic cells and the majority of them are believed to act as E3 ubiquitin ligases. The closely related proteins RNF125/TRAC-1, RNF114 (also known as Zpf313), RNF138 (or NARF) and RNF166 contain, apart from the RING domain, a C2HC (Cys2-His-Cys)- and two C2H2 (Cys2-His2)-type zinc fingers, as well as an ubiquitin interacting motif (UIM) [, , , ].Some proteins known to contain a C2HC RNF-type zinc finger are listed below:Mammalian RNF125/T-cell RING protein in activation 1 (TRAC-1)/, a positive regulator of T-cell activation. It negatively regulates RIG-1 mediated antiviral activity via conjugating ubiquitin chains to RIG-1 and MDA5, leading to their degradation by the proteasome.Vertebrate RNF114, acts as negative regulator of NF-kappaB-dependent transcription. It interacts with A20 in T cells and modulates A20 ubiquitylation.Vertebrate RNF138, likely involved in regulating homologous recombination repair pathway.Vertebrate RNF166, potentiates the RNA virus-induced production of IFN-beta via enhancing the ubiquitination of TRAF3 and TRAF6.
Protein
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 330  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false