Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Pires NM |
Year: |
2021 |
Journal: |
Clin Exp Hypertens |
Title: |
Antagonistic modulation of SIK1 and SIK2 isoforms in high blood pressure and cardiac hypertrophy triggered by high-salt intake. |
Volume: |
43 |
Issue: |
5 |
Pages: |
428-435 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horike N |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. |
Volume: |
278 |
Issue: |
20 |
Pages: |
18440-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horike N |
Year: |
2010 |
Journal: |
Pigment Cell Melanoma Res |
Title: |
Downregulation of SIK2 expression promotes the melanogenic program in mice. |
Volume: |
23 |
Issue: |
6 |
Pages: |
809-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nefla M |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Salt inducible kinases 2 and 3 are required for thymic T cell development. |
Volume: |
11 |
Issue: |
1 |
Pages: |
21550 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park J |
Year: |
2014 |
Journal: |
Diabetes |
Title: |
SIK2 is critical in the regulation of lipid homeostasis and adipogenesis in vivo. |
Volume: |
63 |
Issue: |
11 |
Pages: |
3659-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park M |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need. |
Volume: |
10 |
Issue: |
1 |
Pages: |
8676 |
|
•
•
•
•
•
|
Publication |
First Author: |
Darling NJ |
Year: |
2017 |
Journal: |
Biochem J |
Title: |
Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages. |
Volume: |
474 |
Issue: |
4 |
Pages: |
521-537 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katoh Y |
Year: |
2006 |
Journal: |
FEBS J |
Title: |
Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade. |
Volume: |
273 |
Issue: |
12 |
Pages: |
2730-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Gijsel-Bonnello M |
Year: |
2022 |
Journal: |
J Biol Chem |
Title: |
Salt-inducible kinase 2 regulates fibrosis during bleomycin-induced lung injury. |
Volume: |
298 |
Issue: |
12 |
Pages: |
102644 |
|
•
•
•
•
•
|
Publication |
First Author: |
Popov S |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake. |
Volume: |
9 |
Issue: |
4 |
Pages: |
e95771 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wei T |
Year: |
2019 |
Journal: |
Cell Death Dis |
Title: |
Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions. |
Volume: |
10 |
Issue: |
8 |
Pages: |
614 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakatsu Y |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion. |
Volume: |
292 |
Issue: |
28 |
Pages: |
11886-11895 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang CC |
Year: |
2021 |
Journal: |
Elife |
Title: |
Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption. |
Volume: |
10 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sakamaki J |
Year: |
2014 |
Journal: |
Nat Cell Biol |
Title: |
Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation. |
Volume: |
16 |
Issue: |
3 |
Pages: |
234-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Armouti M |
Year: |
2020 |
Journal: |
Endocrinology |
Title: |
Salt-inducible Kinases Are Critical Determinants of Female Fertility. |
Volume: |
161 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Patel K |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. |
Volume: |
5 |
|
Pages: |
4535 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paulo E |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis. |
Volume: |
8 |
Issue: |
1 |
Pages: |
11001 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bricambert J |
Year: |
2010 |
Journal: |
J Clin Invest |
Title: |
Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. |
Volume: |
120 |
Issue: |
12 |
Pages: |
4316-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Darling NJ |
Year: |
2021 |
Journal: |
J Biol Chem |
Title: |
Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells. |
|
|
Pages: |
100428 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muraoka M |
Year: |
2009 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1alpha and UCP-1 gene expression in brown adipocytes. |
Volume: |
296 |
Issue: |
6 |
Pages: |
E1430-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nishimori S |
Year: |
2019 |
Journal: |
J Clin Invest |
Title: |
Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling. |
Volume: |
129 |
Issue: |
12 |
Pages: |
5187-5203 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7284452 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-06-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610524 |
|
Stage: |
TS24 |
Assay Id: |
MGI:7284703 |
Age: |
embryonic day 16.5 |
|
|
Specimen Label: |
WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7284452 |
Assay Type: |
RT-PCR |
Annotation Date: |
2022-06-10 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610524 |
|
Stage: |
TS24 |
Assay Id: |
MGI:7284703 |
Age: |
embryonic day 16.5 |
|
|
Specimen Label: |
DKO |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425641 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-09-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7525171 |
Age: |
embryonic day 14.5 |
|
Note: |
Cortical plate expression was greater than in the ventricular zone. |
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4425641 |
Assay Type: |
RNA in situ |
Annotation Date: |
2023-09-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7525171 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
Supplementary table 2 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin C |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains. |
Volume: |
12 |
Issue: |
12 |
Pages: |
e0188972 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sanosaka M |
Year: |
2015 |
Journal: |
Immunology |
Title: |
Salt-inducible kinase 3 deficiency exacerbates lipopolysaccharide-induced endotoxin shock accompanied by increased levels of pro-inflammatory molecules in mice. |
Volume: |
145 |
Issue: |
2 |
Pages: |
268-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoon SH |
Year: |
2023 |
Journal: |
J Clin Invest |
Title: |
A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis. |
Volume: |
133 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kim MJ |
Year: |
2015 |
Journal: |
Diabetes |
Title: |
Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells. |
Volume: |
64 |
Issue: |
9 |
Pages: |
3189-202 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wein MN |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
SIKs control osteocyte responses to parathyroid hormone. |
Volume: |
7 |
|
Pages: |
13176 |
|
•
•
•
•
•
|
Publication |
First Author: |
Clark K |
Year: |
2012 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. |
Volume: |
109 |
Issue: |
42 |
Pages: |
16986-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kuwako KI |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
The LKB1-SIK Pathway Controls Dendrite Self-Avoidance in Purkinje Cells. |
Volume: |
24 |
Issue: |
11 |
Pages: |
2808-2818.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Patra KC |
Year: |
2018 |
Journal: |
Nat Cell Biol |
Title: |
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. |
Volume: |
20 |
Issue: |
7 |
Pages: |
811-822 |
|
•
•
•
•
•
|
Publication |
First Author: |
Trivedi CM |
Year: |
2010 |
Journal: |
Dev Cell |
Title: |
Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. |
Volume: |
19 |
Issue: |
3 |
Pages: |
450-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chu Q |
Year: |
2019 |
Journal: |
Cell Discov |
Title: |
STK11 is required for the normal program of ciliated cell differentiation in airways. |
Volume: |
5 |
|
Pages: |
36 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI and IMPC |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bedogni F |
Year: |
2021 |
Journal: |
Front Mol Neurosci |
Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
Volume: |
14 |
|
Pages: |
686034 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
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•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
931
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Fragment?: |
false |
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UniProt Feature |
Begin: |
162 |
Description: |
Phosphoserine; by SIK2 |
Type: |
modified residue |
End: |
162 |
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UniProt Feature |
Begin: |
1 |
Description: |
Serine/threonine-protein kinase SIK2 |
Type: |
chain |
End: |
931 |
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UniProt Feature |
Begin: |
789 |
Description: |
Phosphoserine; by AMPK and SIK2 |
Type: |
modified residue |
End: |
789 |
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UniProt Feature |
Begin: |
171 |
Description: |
Phosphoserine; by AMPK, MARK2, SIK1 and SIK2 |
Type: |
modified residue |
End: |
171 |
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Interaction Experiment |
Description: |
SIK2 regulates fasting-induced PPAR? activity and ketogenesis through p300. |
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Allele |
Name: |
salt inducible kinase 2; targeted mutation 1, PolyGene AG |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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Publication |
First Author: |
Zhang ZN |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300. |
Volume: |
6 |
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Pages: |
23317 |
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Publication |
First Author: |
Ahmed AA |
Year: |
2010 |
Journal: |
Cancer Cell |
Title: |
SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer. |
Volume: |
18 |
Issue: |
2 |
Pages: |
109-21 |
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