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Search results 201 to 271 out of 271 for Mettl3

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Type Details Score
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE181095 | Mettl3 regulates late retinogenesis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Allele
Mettl3<tm1c(KOMP)Wtsi> | MGI:6414842
Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
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UniProt Feature
UniProt Feature
Begin: 146
Description: Interaction with METTL3
Type: site
End: 146
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UniProt Feature
UniProt Feature
Begin: 399
Description: Interaction with METTL3
Type: site
End: 399
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UniProt Feature
UniProt Feature
Begin: 298
Description: Interaction with METTL3
Type: site
End: 298
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UniProt Feature
UniProt Feature
Begin: 245
Description: Interaction with METTL3
Type: site
End: 245
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UniProt Feature
UniProt Feature
Begin: 242
Description: Interaction with METTL3
Type: site
End: 242
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UniProt Feature
UniProt Feature
Begin: 2
Description: N6-adenosine-methyltransferase subunit METTL3
Type: chain
End: 580
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Publication
31914601 | J:299492
First Author: Zhang C
Year: 2020
Journal: FASEB J
Title: METTL3 regulates inflammatory pain by modulating m6A-dependent pri-miR-365-3p processing.
Volume: 34
Issue: 1
Pages: 122-132
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Publication
33902106 | J:334851
First Author: Yankova E
Year: 2021
Journal: Nature
Title: Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.
Volume: 593
Issue: 7860
Pages: 597-601
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Protein
G5E922
Organism: Mus musculus/domesticus
Length: 335  
Fragment?: true
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Protein
Q8C3P7
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
A0A0R4J041
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Publication
31365297 | J:287764
First Author: Liu Y
Year: 2019
Journal: Am J Physiol Cell Physiol
Title: The N6-methyladenosine (m6A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA.
Volume: 317
Issue: 4
Pages: C762-C775
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Protein
Q8C3P7-2
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Protein
G3UYB5
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Protein
G3UX68
Organism: Mus musculus/domesticus
Length: 37  
Fragment?: false
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Protein
G3UXX7
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: true
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Protein
G3UZP2
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Protein
G3UY98
Organism: Mus musculus/domesticus
Length: 36  
Fragment?: false
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Protein
G3UZP3
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
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Protein
G3UXN3
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: true
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HT Experiment
GSE225140 | METTL3 mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling (Ribosome-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE225141 | METTL3 mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling (RNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE147415 | Single-cell RNA-seq of embryonic day 17 (E17) mouse skin epithelial cells with or without Mettl3 knockout
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
36587923 | J:344512
 
First Author: Tang Z
Year: 2023
Journal: Free Radic Biol Med
Title: KDM1A-mediated upregulation of METTL3 ameliorates Alzheimer's disease via enhancing autophagic clearance of p-Tau through m6A-dependent regulation of STUB1.
Volume: 195
Pages: 343-358
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Allele
Mettl3<tm1Smoc> | MGI:7513943
Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready
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Publication
25683224 | -
First Author: Chen T
Year: 2015
Journal: Cell Stem Cell
Title: m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
Volume: 16
Issue: 3
Pages: 289-301
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Publication
28869969 | -
First Author: Zhang C
Year: 2017
Journal: Nature
Title: m6A modulates haematopoietic stem and progenitor cell specification.
Volume: 549
Issue: 7671
Pages: 273-276
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Strain
MGI:6355018 | C57BL/6J-Mettl3<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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HT Experiment
GSE154992 | Combined analysis of ribo-seq and rna-seq reveals that Mettl3 regulates embryonic cerebral cortex development in mice by controlling the proliferation and differentiation of neural progenitor cells
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
27373337 | -
First Author: Wang P
Year: 2016
Journal: Mol Cell
Title: Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Volume: 63
Issue: 2
Pages: 306-317
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Allele
Mettl3<em1Chez> | MGI:7532765
Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit; endonuclease-mediated mutation 1, Zheng Chen
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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Allele
Mettl3<em1Smoc> | MGI:7291047
Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:7513945 | C57BL/6J-Mettl3<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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HT Experiment
GSE100528 | METTL3-mediated m6A modification is required for cerebellar development m6A modification and cerebellar development
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
29535189 | J:345540
First Author: Knuckles P
Year: 2018
Journal: Genes Dev
Title: Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.
Volume: 32
Issue: 5-6
Pages: 415-429
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Publication
27281194 | J:338070
First Author: Wang X
Year: 2016
Journal: Nature
Title: Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.
Volume: 534
Issue: 7608
Pages: 575-8
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Publication
25799998 | J:220463
First Author: Alarcón CR
Year: 2015
Journal: Nature
Title: N6-methyladenosine marks primary microRNAs for processing.
Volume: 519
Issue: 7544
Pages: 482-5
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Protein Domain
IPR025848 | MT-A70
Type: Family
Description: METTL3 and METTL14 (methyltransferase-like) form a methyltransferase complex that methylates adenosine residues at the N6 position of some RNAs, forming N6-methyladenosine (m6A). METTL3, also known as MT-A70, is the catalytic subunit of this complex, and accepts S-adenosyl methionine, a donor for methylation []. m6A, which is present at internal sites of some mRNAs, affects different aspects of mRNA metabolism such as half-life, splicing, and translation [, , , , ].Methyltransferases (EC [intenz:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [, , ]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM []. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [, , ]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [, , ]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.
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Publication
30559377 | J:282659
First Author: Winkler R
Year: 2019
Journal: Nat Immunol
Title: m6A modification controls the innate immune response to infection by targeting type I interferons.
Volume: 20
Issue: 2
Pages: 173-182
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Publication
33707441 | J:304986
First Author: Qiu W
Year: 2021
Journal: Nat Commun
Title: N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA.
Volume: 12
Issue: 1
Pages: 1582
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Publication
30428350 | J:270819
First Author: Zhong X
Year: 2018
Journal: Cell Rep
Title: Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Volume: 25
Issue: 7
Pages: 1816-1828.e4
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Publication
29107534 | J:256786
     
First Author: Coots RA
Year: 2017
Journal: Mol Cell
Title: m6A Facilitates eIF4F-Independent mRNA Translation.
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Publication
33909701 | J:314224
First Author: Xu J
Year: 2021
Journal: PLoS Pathog
Title: The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NFκB transcripts to dampen antiviral innate immunity.
Volume: 17
Issue: 4
Pages: e1009530
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Publication
30967445 | J:287935
 
First Author: Kmietczyk V
Year: 2019
Journal: Life Sci Alliance
Title: m6A-mRNA methylation regulates cardiac gene expression and cellular growth.
Volume: 2
Issue: 2
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Publication
31751468 | J:286650
First Author: Cao Y
Year: 2020
Journal: Hum Mol Genet
Title: Dynamic effects of Fto in regulating the proliferation and differentiation of adult neural stem cells of mice.
Volume: 29
Issue: 5
Pages: 727-735
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Publication
33579825 | J:302608
 
First Author: Chien CS
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: METTL3-dependent N6-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium.
Volume: 118
Issue: 7
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Publication
33848642 | J:330477
First Author: Cao X
Year: 2021
Journal: Cell Mol Gastroenterol Hepatol
Title: Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis.
Volume: 12
Issue: 2
Pages: 633-651
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Publication
35001873 | J:319848
   
First Author: Li B
Year: 2022
Journal: Elife
Title: RNA N6-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice.
Volume: 11
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Publication
38182816 | J:345634
First Author: Xu J
Year: 2024
Journal: EMBO Rep
Title: DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.
Volume: 25
Issue: 2
Pages: 770-795
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Publication
38572146 | J:347091
 
First Author: Jiang L
Year: 2024
Journal: Front Neurosci
Title: β-amyloid accumulation enhances microtubule associated protein tau pathology in an APP(NL-G-F)/MAPT(P301S) mouse model of Alzheimer's disease.
Volume: 18
Pages: 1372297
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Publication
24284625 | -
First Author: Wang X
Year: 2014
Journal: Nature
Title: N6-methyladenosine-dependent regulation of messenger RNA stability.
Volume: 505
Issue: 7481
Pages: 117-20
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Publication
26751643 | -
First Author: Choi J
Year: 2016
Journal: Nat Struct Mol Biol
Title: N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics.
Volume: 23
Issue: 2
Pages: 110-5
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Publication
26593424 | -
First Author: Meyer KD
Year: 2015
Journal: Cell
Title: 5' UTR m(6)A Promotes Cap-Independent Translation.
Volume: 163
Issue: 4
Pages: 999-1010
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Publication
26046440 | -
First Author: Wang X
Year: 2015
Journal: Cell
Title: N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.
Volume: 161
Issue: 6
Pages: 1388-99
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Protein
Q3U6J4
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: true
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Publication
7897657 | -
First Author: Schluckebier G
Year: 1995
Journal: J Mol Biol
Title: Universal catalytic domain structure of AdoMet-dependent methyltransferases.
Volume: 247
Issue: 1
Pages: 16-20
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Publication
16225687 | -
 
First Author: Kozbial PZ
Year: 2005
Journal: BMC Struct Biol
Title: Natural history of S-adenosylmethionine-binding proteins.
Volume: 5
Pages: 19
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Publication
21858014 | -
First Author: Wlodarski T
Year: 2011
Journal: PLoS One
Title: Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltransferome.
Volume: 6
Issue: 8
Pages: e23168
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Publication
12826405 | -
First Author: Schubert HL
Year: 2003
Journal: Trends Biochem Sci
Title: Many paths to methyltransfer: a chronicle of convergence.
Volume: 28
Issue: 6
Pages: 329-35
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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