Type |
Details |
Score |
Publication |
First Author: |
De Vincenti AP |
Year: |
2021 |
Journal: |
Development |
Title: |
Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation. |
Volume: |
148 |
Issue: |
16 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Landy MA |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation. |
Volume: |
34 |
Issue: |
13 |
Pages: |
108913 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saul MC |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
Genomic variants in an inbred mouse model predict mania-like behaviors. |
Volume: |
13 |
Issue: |
5 |
Pages: |
e0197624 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karpinski BA |
Year: |
2022 |
Journal: |
Dis Model Mech |
Title: |
Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome. |
Volume: |
15 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ren AJ |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons. |
Volume: |
5 |
|
Pages: |
4984 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen TR |
Year: |
2012 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Generation and characterization of Tmeff2 mutant mice. |
Volume: |
425 |
Issue: |
2 |
Pages: |
189-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cao Z |
Year: |
2022 |
Journal: |
Front Mol Neurosci |
Title: |
Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli. |
Volume: |
15 |
|
Pages: |
901466 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lopes C |
Year: |
2012 |
Journal: |
J Neurosci |
Title: |
Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors. |
Volume: |
32 |
Issue: |
28 |
Pages: |
9706-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gorokhova S |
Year: |
2014 |
Journal: |
PLoS Genet |
Title: |
Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor. |
Volume: |
10 |
Issue: |
2 |
Pages: |
e1004081 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2020 |
Journal: |
Sci Adv |
Title: |
Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia. |
Volume: |
6 |
Issue: |
1 |
Pages: |
eaay6350 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen ZF |
Year: |
2001 |
Journal: |
Neuron |
Title: |
The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. |
Volume: |
31 |
Issue: |
1 |
Pages: |
59-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Angueira AR |
Year: |
2021 |
Journal: |
Nat Metab |
Title: |
Defining the lineage of thermogenic perivascular adipose tissue. |
Volume: |
3 |
Issue: |
4 |
Pages: |
469-484 |
|
•
•
•
•
•
|
Publication |
First Author: |
da Silva S |
Year: |
2011 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling. |
Volume: |
108 |
Issue: |
8 |
Pages: |
3395-400 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lowenstein ED |
Year: |
2023 |
Journal: |
Neuron |
Title: |
Prox2 and Runx3 vagal sensory neurons regulate esophageal motility. |
Volume: |
111 |
Issue: |
14 |
Pages: |
2184-2200.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo W |
Year: |
2007 |
Journal: |
Neuron |
Title: |
A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. |
Volume: |
54 |
Issue: |
5 |
Pages: |
739-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen CL |
Year: |
2006 |
Journal: |
Neuron |
Title: |
Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. |
Volume: |
49 |
Issue: |
3 |
Pages: |
365-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramsey IS |
Year: |
2006 |
Journal: |
Annu Rev Physiol |
Title: |
An introduction to TRP channels. |
Volume: |
68 |
|
Pages: |
619-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Asai Y |
Year: |
2010 |
Journal: |
J Assoc Res Otolaryngol |
Title: |
A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea. |
Volume: |
11 |
Issue: |
1 |
Pages: |
27-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
De Clercq K |
Year: |
2021 |
Journal: |
Cell Mol Life Sci |
Title: |
Mapping the expression of transient receptor potential channels across murine placental development. |
Volume: |
78 |
Issue: |
11 |
Pages: |
4993-5014 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dumas S |
Year: |
2019 |
Journal: |
Front Cell Dev Biol |
Title: |
Developmental Co-expression of Vglut2 and Nurr1 in a Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron Specification. |
Volume: |
7 |
|
Pages: |
307 |
|
•
•
•
•
•
|
Publication |
First Author: |
Desiderio S |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA. |
Volume: |
26 |
Issue: |
13 |
Pages: |
3522-3536.e5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wickramasinghe SR |
Year: |
2008 |
Journal: |
Neuron |
Title: |
Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons. |
Volume: |
58 |
Issue: |
4 |
Pages: |
532-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xia W |
Year: |
2018 |
Journal: |
J Cell Biol |
Title: |
Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability in cold stress. |
Volume: |
217 |
Issue: |
10 |
Pages: |
3464-3479 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lechner SG |
Year: |
2009 |
Journal: |
EMBO J |
Title: |
Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. |
Volume: |
28 |
Issue: |
10 |
Pages: |
1479-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2001 |
|
Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
transient receptor potential cation channel, subfamily V, member 1; targeted mutation 1, John B Davis |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Vti1b promotes TRPV1 sensitization during inflammatory pain. |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors. |
|
•
•
•
•
•
|
Publication |
First Author: |
Patel KN |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Pirt, a TRPV1 modulator, is required for histamine-dependent and -independent itch. |
Volume: |
6 |
Issue: |
5 |
Pages: |
e20559 |
|
•
•
•
•
•
|
Publication |
First Author: |
Han Q |
Year: |
2016 |
Journal: |
Neuron |
Title: |
SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. |
Volume: |
92 |
Issue: |
6 |
Pages: |
1279-1293 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ufret-Vincenty CA |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
Localization of the PIP2 sensor of TRPV1 ion channels. |
Volume: |
286 |
Issue: |
11 |
Pages: |
9688-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Langeslag M |
Year: |
2011 |
Journal: |
Mol Pain |
Title: |
Oncostatin M induces heat hypersensitivity by gp130-dependent sensitization of TRPV1 in sensory neurons. |
Volume: |
7 |
|
Pages: |
102 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arnold WR |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel. |
Volume: |
12 |
Issue: |
1 |
Pages: |
926 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2021 |
Journal: |
J Allergy Clin Immunol |
Title: |
Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors. |
Volume: |
147 |
Issue: |
6 |
Pages: |
2236-2248.e16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bogdan DM |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
FABP5 deletion in nociceptors augments endocannabinoid signaling and suppresses TRPV1 sensitization and inflammatory pain. |
Volume: |
12 |
Issue: |
1 |
Pages: |
9241 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:4354373 |
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2024-03-12 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1666828 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:7611628 |
Age: |
postnatal adult |
|
Note: |
GFP-immunoreactive cells were detected. Co-labeling with the sensory neuron marker, Trpv1 was observed. |
Specimen Label: |
S3D |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Y |
Year: |
2019 |
Journal: |
Mol Pain |
Title: |
TLR4 mediates upregulation and sensitization of TRPV1 in primary afferent neurons in 2,4,6-trinitrobenzene sulfate-induced colitis. |
Volume: |
15 |
|
Pages: |
1744806919830018 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
829
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Negri L |
Year: |
2006 |
Journal: |
J Neurosci |
Title: |
Impaired nociception and inflammatory pain sensation in mice lacking the prokineticin receptor PKR1: focus on interaction between PKR1 and the capsaicin receptor TRPV1 in pain behavior. |
Volume: |
26 |
Issue: |
25 |
Pages: |
6716-27 |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Protein kinase A anchoring via AKAP150 is essential for TRPV1 modulation by forskolin and prostaglandin E2 in mouse sensory neurons. |
|
•
•
•
•
•
|
Publication |
First Author: |
Janssen DA |
Year: |
2016 |
Journal: |
Pflugers Arch |
Title: |
TRPV4 mediates afferent pathways in the urinary bladder. A spinal c-fos study showing TRPV1 related adaptations in the TRPV4 knockout mouse. |
Volume: |
468 |
Issue: |
10 |
Pages: |
1741-9 |
|
•
•
•
•
•
|
Allele |
Name: |
transient receptor potential cation channel, subfamily V, member 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Michael D Ehlers |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Cevikbas F |
Year: |
2014 |
Journal: |
J Allergy Clin Immunol |
Title: |
A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1. |
Volume: |
133 |
Issue: |
2 |
Pages: |
448-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao Y |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors. |
Volume: |
39 |
Issue: |
11 |
Pages: |
110972 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Mark A Hoon |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 5917, Jan Siemens |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Arenkiel BR |
Year: |
2008 |
Journal: |
Nat Methods |
Title: |
Genetic control of neuronal activity in mice conditionally expressing TRPV1. |
Volume: |
5 |
Issue: |
4 |
Pages: |
299-302 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion MA208, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion SK30, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Klas Kullander |
Allele Type: |
Transgenic |
Attribute String: |
Recombinase |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
135
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Phosphoinositide-Binding Protein (PIRT) is thought to have a role in positively regulating transient receptor potential vanilloid 1 (TRPV1) channel activity via phosphatidylinositol 4,5-bisphosphate (PIP2) []. TRPV1 is a molecular sensor of noxious heat and capsaicin.PIRT is predicted to be a multi-pass membrane protein and is located in the cell membrane []. |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant stock |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
Not Specified |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Trpv1-cre)1Hoon/? |
Background: |
Not Specified |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
Baseline |
Source: |
GEO |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Trpv1-cre)1Hoon/? |
Background: |
involves: 129S1/Sv |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Fernández-Trillo J |
Year: |
2020 |
Journal: |
J Neurosci |
Title: |
Piezo2 Mediates Low-Threshold Mechanically Evoked Pain in the Cornea. |
Volume: |
40 |
Issue: |
47 |
Pages: |
8976-8993 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Nes-cre)1Wme/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * CBA |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Slc17a6/Slc17a6 Tg(Trpv1-icre)1Kldr/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|