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Search results 1101 to 1200 out of 1327 for Lif

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Hits by Pathway

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Lifr/Lifr<+>
Background: B6;129S7-Lifr/J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lifr/Lifr<+>
Background: C57BL/6N-Lifr/H
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lifr/Lifr<+>
Background: involves: 129 * 129S7/SvEvBrd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lifr/Lifr<+>
Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lifr/Lifr<+>
Background: involves: 129P3/J * 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lifr/Lifr<+>
Background: either: (involves: 129P2/OlaHsd * CBA) or (involves: 129P2/OlaHsd * MF1)
Zygosity: ht
Has Mutant Allele: true
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Publication
17299136 | J:120902
First Author: Magni P
Year: 2007
Journal: Mol Endocrinol
Title: Leukemia inhibitory factor induces the chemomigration of immortalized gonadotropin-releasing hormone neurons through the independent activation of the Janus kinase/signal transducer and activator of transcription 3, mitogen-activated protein kinase/extracellularly regulated kinase 1/2, and phosphatidylinositol 3-kinase/Akt signaling pathways.
Volume: 21
Issue: 5
Pages: 1163-74
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Strain
MGI:6332848 | B6.Cg-Lyz2<tm1(cre)Ifo> Lifr<tm1a(EUCOMM)Hmgu>/JAusbAnu
Attribute String: mutant strain, congenic, targeted mutation
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Publication
27539849 | J:237300
First Author: Walker EC
Year: 2016
Journal: J Biol Chem
Title: Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass.
Volume: 291
Issue: 41
Pages: 21703-21716
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GO Term
GO:0038165 | oncostatin-M-mediated signaling pathway
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Publication
8276403 | J:15137
First Author: Gearing DP
Year: 1993
Journal: Genomics
Title: The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13.
Volume: 18
Issue: 1
Pages: 148-50
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HT Experiment
GSE218405 | Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
21998580 | J:261895
First Author: Wuest T
Year: 2011
Journal: PLoS Pathog
Title: The herpes simplex virus-1 transactivator infected cell protein-4 drives VEGF-A dependent neovascularization.
Volume: 7
Issue: 10
Pages: e1002278
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Publication
9454853 | J:45763
First Author: Arce V
Year: 1998
Journal: J Neurosci
Title: Synergistic effects of schwann- and muscle-derived factors on motoneuron survival involve GDNF and cardiotrophin-1 (CT-1).
Volume: 18
Issue: 4
Pages: 1440-8
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Protein Domain
IPR040901 | LIFR_N
Type: Domain
Description: This domain can be found in leukemia inhibitory factor receptor (LIFR). LIFR is a cell surface receptor that mediates the actions of LIF and other interleukin-6 type cytokines through the formation of signalling complexes with gp130. This is the N-terminal domain, referred to as domain 1, which contains conserved disulfide bonds between Cys-10 to Cys-20 and Cys-37 to Cys-45 [].
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Protein Domain
IPR001581 | Leukemia_IF/oncostatin
Type: Family
Description: On the basis of functional and structural similarities, the small cytokines leukemia inhibitory factor (LIF) and oncostatin (OSM) can be classified into a single family [, ].It has been said []that LIF and OSM can be included in the IL-6 family of cytokines, but while all these cytokines seem to be structurally related, the sequence similarity is not high enough to allow the use of a single consensus pattern.
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Publication
10564261 | J:58439
First Author: Takagi M
Year: 1999
Journal: Mol Biol Cell
Title: Chimeric cytokine receptor can transduce expansion signals in interleukin 6 receptor alpha (IL-6Ralpha)-, IL-11Ralpha-, and gp130-low to -negative primitive hematopoietic progenitors.
Volume: 10
Issue: 11
Pages: 3633-42
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Publication
8001975 | J:19872
First Author: Kirschner MA
Year: 1994
Journal: Genomics
Title: The mouse and human excitatory amino acid transporter gene (EAAT1) maps to mouse chromosome 15 and a region of syntenic homology on human chromosome 5.
Volume: 22
Issue: 3
Pages: 631-3
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Publication
12831858 | J:84736
First Author: Tamura S
Year: 2003
Journal: Neuroscience
Title: Localization of oncostatin M receptor beta in adult and developing CNS.
Volume: 119
Issue: 4
Pages: 991-7
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Publication
24594094 | J:356300
First Author: Finn EH
Year: 2014
Journal: Dev Biol
Title: Maternal bias and escape from X chromosome imprinting in the midgestation mouse placenta.
Volume: 390
Issue: 1
Pages: 80-92
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HT Experiment
E-GEOD-74155 | Single-cell analysis of allelic gene expression in pluripotency, differentiation and X-chromosome inactivation
Series Id: GSE74155
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
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Allele
Tg(Scgb1a1-rtTA,tetO-LIF)1Eli | MGI:3835961
Name: transgene insertion 1, Jack A Elias
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence, Transactivator
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Allele
Tg(Scgb1a1-rtTA,tetO-Nos2)1Eli | MGI:3836006
Name: transgene insertion 1, Jack A Elias
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Transactivator
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Allele
Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli | MGI:3836020
Name: transgene insertion 14, Jack A Elias
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Transactivator
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Allele
Tg(Scgb1a1-rtTA,tetO-Il11)1Eli | MGI:3836050
Name: transgene insertion 1, Jack A Elias
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Transactivator
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Allele
Tg(Scgb1a1-rtTA,tetO-IL9)1Flv | MGI:3836062
Name: transgene insertion 1, Richard A Flavell
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence, Transactivator
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HT Experiment
GSE157555 | Fetal brain elicits sexually conflicting transcriptional response to the deficiency of uterine Forkhead Box A2 (Foxa2) in mice
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
2026606 | -
First Author: Kallestad JC
Year: 1991
Journal: J Biol Chem
Title: Disulfide bond assignment and identification of regions required for functional activity of oncostatin M.
Volume: 266
Issue: 14
Pages: 8940-5
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Protein Domain
IPR019827 | Leukemia_IF/oncostatin_CS
Type: Conserved_site
Description: On the basis of functional and structural similarities, the small cytokines leukemia inhibitory factor (LIF) and oncostatin (OSM) can be classified into a single family [, ].It has been said []that LIF and OSM can be included in the IL-6 family of cytokines, but while all these cytokines seem to be structurally related, the sequence similarity is not high enough to allow the use of a single consensus pattern.The signature pattern for this entry is based on a conserved region in the C-terminal region. This region is centred on a conserved cysteine which has been shown, in OSM, to be involved in a disulphide bond [].
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Publication
15051883 | J:89246
First Author: Derouet D
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.
Volume: 101
Issue: 14
Pages: 4827-32
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Publication
15020581 | J:131101
First Author: Hjoberg J
Year: 2004
Journal: J Appl Physiol (1985)
Title: Expression of nitric oxide synthase-2 in the lungs decreases airway resistance and responsiveness.
Volume: 97
Issue: 1
Pages: 249-59
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Publication
11104801 | J:66079
First Author: Wang Z
Year: 2000
Journal: J Exp Med
Title: Interferon gamma induction of pulmonary emphysema in the adult murine lung.
Volume: 192
Issue: 11
Pages: 1587-600
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Publication
23470621 | J:211748
First Author: Choo-Wing R
Year: 2013
Journal: Am J Respir Cell Mol Biol
Title: Hyperoxia and interferon-γ-induced injury in developing lungs occur via cyclooxygenase-2 and the endoplasmic reticulum stress-dependent pathway.
Volume: 48
Issue: 6
Pages: 749-57
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Publication
11781348 | J:130417
First Author: Temann UA
Year: 2002
Journal: J Clin Invest
Title: Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology.
Volume: 109
Issue: 1
Pages: 29-39
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Genotype
Genotype
Symbol: Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/?
Background: involves: C57BL/6 * CBA
Zygosity: ot
Has Mutant Allele: true
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Publication
1717982 | -
First Author: Rose TM
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.
Volume: 88
Issue: 19
Pages: 8641-5
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Publication
1566332 | -
First Author: Hilton DJ
Year: 1992
Journal: Trends Biochem Sci
Title: LIF: lots of interesting functions.
Volume: 17
Issue: 2
Pages: 72-6
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Protein
P53347
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
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Protein
F8WH42
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: false
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Protein
Q3U1H5
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: false
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Publication
16284650 | J:104580
First Author: Ma B
Year: 2005
Journal: J Clin Invest
Title: Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema.
Volume: 115
Issue: 12
Pages: 3460-72
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Publication
21216975 | J:214716
First Author: Harijith A
Year: 2011
Journal: Am J Respir Cell Mol Biol
Title: A role for matrix metalloproteinase 9 in IFNγ-mediated injury in developing lungs: relevance to bronchopulmonary dysplasia.
Volume: 44
Issue: 5
Pages: 621-30
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Publication
9576762 | J:145769
First Author: Waxman AB
Year: 1998
Journal: J Clin Invest
Title: Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.
Volume: 101
Issue: 9
Pages: 1970-82
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Genotype
Genotype
Symbol: Ctss/Ctss Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/?
Background: involves: 129S2/SvPas * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Publication
30658714 | J:272505
First Author: Catela C
Year: 2019
Journal: Neural Dev
Title: An ancient role for collier/Olf/Ebf (COE)-type transcription factors in axial motor neuron development.
Volume: 14
Issue: 1
Pages: 2
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Publication
11730713 | J:73366
First Author: Azari MF
Year: 2001
Journal: Brain Res
Title: Leukemia inhibitory factor by systemic administration rescues spinal motor neurons in the SOD1 G93A murine model of familial amyotrophic lateral sclerosis.
Volume: 922
Issue: 1
Pages: 144-7
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Protein
Q8C2U4
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: true
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Publication
12097503 | J:124527
First Author: Hatta T
Year: 2002
Journal: J Neurosci
Title: The Role of gp130 in cerebral cortical development: in vivo functional analysis in a mouse exo utero system.
Volume: 22
Issue: 13
Pages: 5516-24
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Publication
8404048 | J:14732
First Author: Giovannini M
Year: 1993
Journal: Cytogenet Cell Genet
Title: Tandem linkage of genes coding for leukemia inhibitory factor (LIF) and oncostatin M (OSM) on human chromosome 22.
Volume: 64
Issue: 3-4
Pages: 240-4
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Publication
8272873 | J:172926
First Author: Stahl N
Year: 1994
Journal: Science
Title: Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.
Volume: 263
Issue: 5143
Pages: 92-5
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Publication
15944319 | J:100854
First Author: Zheng T
Year: 2005
Journal: J Immunol
Title: Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema.
Volume: 174
Issue: 12
Pages: 8106-15
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Genotype
Genotype
Symbol: Casp3/Casp3 Tg(Scgb1a1-rtTA,tetO-Ifng)14Eli/?
Background: involves: 129S1/Sv * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
E-GEOD-44087 | Gene expression profiling of mouse uterine epithelial cells isolated on morning of day 4 of pregnancy
Series Id: GSE44087
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein Coding Gene
MGI:1330819 | Osmr
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
29379870 | J:262472
 
First Author: Edmond M
Year: 2017
Journal: eNeuro
Title: Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs.
Volume: 4
Issue: 6
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Publication
15378055 | J:93253
First Author: Lee CG
Year: 2004
Journal: Nat Med
Title: Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.
Volume: 10
Issue: 10
Pages: 1095-103
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Publication
15841185 | J:97367
First Author: He CH
Year: 2005
Journal: J Clin Invest
Title: Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury.
Volume: 115
Issue: 4
Pages: 1039-48
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Publication
9590174 | J:47298
First Author: Neubauer H
Year: 1998
Journal: Cell
Title: Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis.
Volume: 93
Issue: 3
Pages: 397-409
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Publication
8548812 | J:30407
First Author: Tartaglia LA
Year: 1995
Journal: Cell
Title: Identification and expression cloning of a leptin receptor, OB-R.
Volume: 83
Issue: 7
Pages: 1263-71
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Publication
23040478 | J:193651
First Author: Martello G
Year: 2012
Journal: Cell Stem Cell
Title: Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal.
Volume: 11
Issue: 4
Pages: 491-504
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Publication
16596657 | J:115751
First Author: Hariri LP
Year: 2006
Journal: Lasers Surg Med
Title: Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model.
Volume: 38
Issue: 4
Pages: 305-13
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Publication
16966486 | J:114638
First Author: Samardzija M
Year: 2006
Journal: FASEB J
Title: Differential role of Jak-STAT signaling in retinal degenerations.
Volume: 20
Issue: 13
Pages: 2411-3
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Publication
20016025 | J:168273
First Author: Grossberg AJ
Year: 2010
Journal: Endocrinology
Title: Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130.
Volume: 151
Issue: 2
Pages: 606-16
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Publication
8608598 | J:31325
First Author: Durbin JE
Year: 1996
Journal: Cell
Title: Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease.
Volume: 84
Issue: 3
Pages: 443-50
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Publication
29934619 | J:266260
First Author: Kelleher AM
Year: 2018
Journal: Nat Commun
Title: Uterine glands coordinate on-time embryo implantation and impact endometrial decidualization for pregnancy success.
Volume: 9
Issue: 1
Pages: 2435
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Publication
28543818 | J:274935
First Author: Koide M
Year: 2017
Journal: J Bone Miner Res
Title: Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts.
Volume: 32
Issue: 10
Pages: 2074-2086
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Publication
11591128 | J:86898
First Author: Alonzi T
Year: 2001
Journal: Mol Cell Neurosci
Title: Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons.
Volume: 18
Issue: 3
Pages: 270-82
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Publication
18665789 | J:157294
First Author: Walker EC
Year: 2008
Journal: J Bone Miner Res
Title: Cardiotrophin-1 is an osteoclast-derived stimulus of bone formation required for normal bone remodeling.
Volume: 23
Issue: 12
Pages: 2025-32
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Publication
22357924 | J:182743
First Author: Sakimoto S
Year: 2012
Journal: Development
Title: A role for endothelial cells in promoting the maturation of astrocytes through the apelin/APJ system in mice.
Volume: 139
Issue: 7
Pages: 1327-35
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Publication
33222288 | J:307640
First Author: Marquardt RM
Year: 2021
Journal: FASEB J
Title: Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment.
Volume: 35
Issue: 2
Pages: e21209
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Publication
20813103 | J:166618
First Author: Mu W
Year: 2010
Journal: Dev Biol
Title: PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance.
Volume: 347
Issue: 2
Pages: 279-88
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Publication
24905170 | J:228270
First Author: Yeo JC
Year: 2014
Journal: Cell Stem Cell
Title: Klf2 is an essential factor that sustains ground state pluripotency.
Volume: 14
Issue: 6
Pages: 864-72
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Publication
26188092 | J:297356
First Author: Li WZ
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Hesx1 enhances pluripotency by working downstream of multiple pluripotency-associated signaling pathways.
Volume: 464
Issue: 3
Pages: 936-42
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Publication
2491897 | J:9516
First Author: Sutherland GR
Year: 1989
Journal: Leukemia
Title: The gene for human leukemia inhibitory factor (LIF) maps to 22q12.
Volume: 3
Issue: 1
Pages: 9-13
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Publication
9740655 | J:50002
First Author: Hara T
Year: 1998
Journal: Dev Biol
Title: Distinct roles of oncostatin M and leukemia inhibitory factor in the development of primordial germ cells and sertoli cells in mice.
Volume: 201
Issue: 2
Pages: 144-53
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Publication
7914698 | J:129016
First Author: Bamber BA
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: Leukemia inhibitory factor induces neurotransmitter switching in transgenic mice.
Volume: 91
Issue: 17
Pages: 7839-43
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Publication
19618472 | J:151560
First Author: Scotland KB
Year: 2009
Journal: Dev Dyn
Title: Analysis of Rex1 (zfp42) function in embryonic stem cell differentiation.
Volume: 238
Issue: 8
Pages: 1863-77
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Publication
23746443 | J:199311
First Author: Morgani SM
Year: 2013
Journal: Cell Rep
Title: Totipotent embryonic stem cells arise in ground-state culture conditions.
Volume: 3
Issue: 6
Pages: 1945-57
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Publication
23344953 | J:203517
First Author: Zhang J
Year: 2013
Journal: J Biol Chem
Title: BMP induces cochlin expression to facilitate self-renewal and suppress neural differentiation of mouse embryonic stem cells.
Volume: 288
Issue: 12
Pages: 8053-60
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Publication
30154213 | J:267060
 
First Author: Sutherland L
Year: 2018
Journal: J Cell Sci
Title: LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein.
Volume: 131
Issue: 18
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Publication
32795400 | J:338519
First Author: Skelly DA
Year: 2020
Journal: Cell Stem Cell
Title: Mapping the Effects of Genetic Variation on Chromatin State and Gene Expression Reveals Loci That Control Ground State Pluripotency.
Volume: 27
Issue: 3
Pages: 459-469.e8
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Publication
22305567 | J:317085
First Author: Li Z
Year: 2012
Journal: Cell Stem Cell
Title: BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells.
Volume: 10
Issue: 2
Pages: 171-82
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Publication
37584546 | J:353438
First Author: Wang P
Year: 2024
Journal: Autophagy
Title: The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity.
Volume: 20
Issue: 1
Pages: 58-75
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Protein Coding Gene
MGI:104749 | Osm
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19228596 | J:152946
First Author: Sferruzzi-Perri AN
Year: 2009
Journal: Biol Reprod
Title: Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice.
Volume: 81
Issue: 1
Pages: 207-21
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Publication
9584176 | J:47670
First Author: Lindberg RA
Year: 1998
Journal: Mol Cell Biol
Title: Cloning and characterization of a specific receptor for mouse oncostatin M.
Volume: 18
Issue: 6
Pages: 3357-67
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Publication
10842358 | J:69576
First Author: Gendron RL
Year: 2000
Journal: Dev Dyn
Title: Tubedown-1, a novel acetyltransferase associated with blood vessel development.
Volume: 218
Issue: 2
Pages: 300-15
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Publication
21235343 | J:243396
First Author: Vizlin-Hodzic D
Year: 2011
Journal: Cell Reprogram
Title: SAF-A has a role in transcriptional regulation of Oct4 in ES cells through promoter binding.
Volume: 13
Issue: 1
Pages: 13-27
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Publication
15351786 | J:93660
First Author: Geserick P
Year: 2004
Journal: Int Immunol
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