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Search results 1201 to 1300 out of 1313 for Nrg1

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Type Details Score
Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:345476
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Allele
Nrg1<tm1Jya> | MGI:7488428
Name: neuregulin 1; targeted mutation 1, Junji Yamauchi
Allele Type: Targeted
Attribute String: Modified isoform(s)
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Allele
Tg(Camk2a-Nrg1_iIII)#Cysw | MGI:6275830
Name: transgene insertion, Cynthia S Weickert
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Modified isoform(s)
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HT Experiment
E-MTAB-5772 | Transcription profiling of wild type and XY Nrg1 knock out male pooled embryonic gonads to decipher the role of this gene in sexual differentiation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
19659570 | J:160209
First Author: Buac K
Year: 2009
Journal: Pigment Cell Melanoma Res
Title: NRG1 / ERBB3 signaling in melanocyte development and melanoma: inhibition of differentiation and promotion of proliferation.
Volume: 22
Issue: 6
Pages: 773-84
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GO Term
GO:0038131 | neuregulin receptor activity
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Publication
23390248 | J:194531
First Author: Hegde GV
Year: 2013
Journal: Sci Transl Med
Title: Blocking NRG1 and other ligand-mediated Her4 signaling enhances the magnitude and duration of the chemotherapeutic response of non-small cell lung cancer.
Volume: 5
Issue: 171
Pages: 171ra18
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Allele
Tg(tetO-Nrg1)1Smoc | MGI:7292757
Name: transgene insertion 1, Shanghai Model Organisms Center
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Allele
Tg(Thy1-Nrg1*III)1Kan | MGI:3530751
Name: transgene insertion 1, Klaus-Armin Nave
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Thy1-Nrg1*I)1Kan | MGI:3530750
Name: transgene insertion 1, Klaus-Armin Nave
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Nrg1<tm1Zhou> | MGI:1928830
Name: neuregulin 1; targeted mutation 1, Mingdong Zhou
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tg(Mpz-Nrg1)34Slca | MGI:3514151
Name: transgene insertion 34, Steven L Carroll
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Mpz-Nrg1)33Slca | MGI:3514148
Name: transgene insertion 33, Steven L Carroll
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Thy1-Nrg1*I)1Kan/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-Nrg1*III)1Kan/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-Nrg1*I)1Kan/?
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Allele
Nrg1<em2(cre/ERT2)Bzsh> | MGI:6361465
Name: neuregulin 1; endonuclease-mediated mutation 2, Bin Zhou
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, Inducible, Recombinase
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Allele
Tg(Nrg1-EGFP)LS131Gsat | MGI:4847274
Name: transgene insertion LS131, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Genotype
Genotype
Symbol: Nrg1/Nrg1
Background: involves: 129S1/Sv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nrg1/Nrg1<+>
Background: involves: 129S1/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Protein Domain
IPR002154 | Neuregulin_C
Type: Domain
Description: Neuregulins are a sub-family of EGF-like molecules that have been shown to play multiple essential roles in vertebrate embryogenesis including: cardiac development, Schwann cell and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses [, ]. Included in the family are heregulin; neu differentiation factor; acetylcholine receptor synthesis stimulator; glial growth factor; and sensory and motor-neuron derived factor []. Multiple family members are generated by alternate splicing or by use of several cell type-specific transcription initiation sites. In general, they bind to and activate the erbB family of receptor tyrosine kinases (erbB2 (HER2), erbB3 (HER3), and erbB4 (HER4)), functioning both as heterodimers and homodimers.The transmembrane forms of neuregulin 1 (NRG1) are present within synaptic vesicles, including those containing glutamate []. After exocytosis, NRG1 is in the presynaptic membrane, where the ectodomain of NRG1 may be cleaved off. The ectodomain then migrates across the synaptic cleft and binds to and activates a member of the EGF-receptor family on the postsynaptic membrane. This has been shown to increase the expression of certain glutamate-receptor subunits. NRG1 appears to signal for glutamate-receptor subunit expression, localisation, and /or phosphorylation facilitating subsequent glutamate transmission. The NRG1 gene has been identified as a potential gene determining susceptibility to schizophrenia by a combination of genetic linkage and association approaches []. Membrane-anchored Nrg-1 isoforms consist of a variable N-terminal extracellular domain and a conserved transmembrane and C-terminal cytoplasmic domains []. This entry represents the C-terminal, intracellular domain.
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Publication
25150498 | J:227754
First Author: Fledrich R
Year: 2014
Journal: Nat Med
Title: Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A.
Volume: 20
Issue: 9
Pages: 1055-61
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Publication
24232507 | J:318855
First Author: Brosius SN
Year: 2014
Journal: Acta Neuropathol
Title: Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis.
Volume: 127
Issue: 4
Pages: 573-91
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Allele
Nrg1<em1(cre/ERT2)Bzsh> | MGI:6361462
Name: neuregulin 1; endonuclease-mediated mutation 1, Bin Zhou
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Strain
MGI:5004240 | STOCK Tg(Nrg1-EGFP)LS131Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Bace1/Bace1 Tg(Thy1-Nrg1*I)1Kan/?
Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nrg1/Nrg1<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Allele
Tg(Thy1-Nrg1)FLMhsb | MGI:6303795
Name: transgene insertion FL, Markus H Schwab
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
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Genotype
Genotype
Symbol: Nrg1/Nrg1<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Publication
29740596 | J:263284
 
First Author: Kotzadimitriou D
Year: 2018
Journal: eNeuro
Title: Neuregulin 1 Type I Overexpression Is Associated with Reduced NMDA Receptor-Mediated Synaptic Signaling in Hippocampal Interneurons Expressing PV or CCK.
Volume: 5
Issue: 2
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Allele
Tg(Thy1-Nrg1)GIEFMhsb | MGI:6303796
Name: transgene insertion GIEF, Markus H Schwab
Allele Type: Transgenic
Attribute String: Epitope tag, Inserted expressed sequence
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Protein
D3YZR3
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nrg1/Nrg1<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nrg1/Nrg1<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
25848746 | J:307369
First Author: D'Uva G
Year: 2015
Journal: Nat Cell Biol
Title: ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.
Volume: 17
Issue: 5
Pages: 627-38
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Publication
19805360 | J:153219
First Author: Grossmann KS
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development.
Volume: 106
Issue: 39
Pages: 16704-9
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Publication
29748249 | J:272610
First Author: Kim M
Year: 2018
Journal: Genes Dev
Title: Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.
Volume: 32
Issue: 9-10
Pages: 645-657
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Publication
32822611 | J:328631
First Author: Grieco SF
Year: 2020
Journal: Curr Biol
Title: Subanesthetic Ketamine Reactivates Adult Cortical Plasticity to Restore Vision from Amblyopia.
Volume: 30
Issue: 18
Pages: 3591-3603.e8
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Publication
33627623 | J:314613
First Author: Grieco SF
Year: 2021
Journal: Transl Psychiatry
Title: Neuregulin signaling mediates the acute and sustained antidepressant effects of subanesthetic ketamine.
Volume: 11
Issue: 1
Pages: 144
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Publication
26318331 | J:227525
 
First Author: Guan YF
Year: 2015
Journal: Neuroscience
Title: Neuregulin 1 protects against ischemic brain injury via ErbB4 receptors by increasing GABAergic transmission.
Volume: 307
Pages: 151-9
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Publication
24412575 | J:208347
First Author: Forster N
Year: 2014
Journal: Dev Cell
Title: Basal cell signaling by p63 controls luminal progenitor function and lactation via NRG1.
Volume: 28
Issue: 2
Pages: 147-60
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Publication
21441918 | J:171622
First Author: Pitcher GM
Year: 2011
Journal: Nat Med
Title: Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors.
Volume: 17
Issue: 4
Pages: 470-8
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Publication
26844833 | J:268173
First Author: Marques-Smith A
Year: 2016
Journal: Neuron
Title: A Transient Translaminar GABAergic Interneuron Circuit Connects Thalamocortical Recipient Layers in Neonatal Somatosensory Cortex.
Volume: 89
Issue: 3
Pages: 536-49
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nrg1/Nrg1<+> Tg(CAG-dre)1Afst/?
Background: involves: 129 * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Nrg1/Nrg1<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
38311982 | J:345924
First Author: Hong J
Year: 2024
Journal: Glia
Title: PMP2 regulates myelin thickening and ATP production during remyelination.
Volume: 72
Issue: 5
Pages: 885-898
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Publication
23553667 | J:198542
First Author: Gouttenoire EA
Year: 2013
Journal: Glia
Title: Sh3tc2 deficiency affects neuregulin-1/ErbB signaling.
Volume: 61
Issue: 7
Pages: 1041-51
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Publication
26628400 | J:231381
 
First Author: Brzózka MM
Year: 2016
Journal: Neuroscience
Title: OSO paradigm--A rapid behavioral screening method for acute psychosocial stress reactivity in mice.
Volume: 314
Pages: 1-11
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Publication
26187852 | J:233043
First Author: Sonnenberg-Riethmacher E
Year: 2015
Journal: J Cell Sci
Title: Promotion of periostin expression contributes to the migration of Schwann cells.
Volume: 128
Issue: 17
Pages: 3345-55
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Publication
30637799 | J:274330
First Author: Bartus K
Year: 2019
Journal: Glia
Title: ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury.
Volume: 67
Issue: 6
Pages: 1036-1046
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Publication
30506868 | J:273251
First Author: Truong PH
Year: 2019
Journal: Glia
Title: Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons.
Volume: 67
Issue: 3
Pages: 525-538
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Publication
23063798 | J:190992
First Author: Harmelink C
Year: 2013
Journal: Dev Biol
Title: Myocardial Mycn is essential for mouse ventricular wall morphogenesis.
Volume: 373
Issue: 1
Pages: 53-63
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Publication
23437108 | J:199337
First Author: Ronchi G
Year: 2013
Journal: PLoS One
Title: ErbB2 receptor over-expression improves post-traumatic peripheral nerve regeneration in adult mice.
Volume: 8
Issue: 2
Pages: e56282
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Publication
28322273 | J:301708
First Author: Yan L
Year: 2018
Journal: Mol Psychiatry
Title: Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders.
Volume: 23
Issue: 5
Pages: 1233-1243
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Publication
30498032 | J:269263
First Author: Wang H
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Genetic recovery of ErbB4 in adulthood partially restores brain functions in null mice.
Volume: 115
Issue: 51
Pages: 13105-13110
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Publication
33584196 | J:335366
 
First Author: Wan C
Year: 2021
Journal: Front Neurosci
Title: Neuregulin1-ErbB4 Signaling in Spinal Cord Participates in Electroacupuncture Analgesia in Inflammatory Pain.
Volume: 15
Pages: 636348
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Publication
21209185 | J:167978
First Author: Ting AK
Year: 2011
Journal: J Neurosci
Title: Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons.
Volume: 31
Issue: 1
Pages: 15-25
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Publication
28727685 | J:284651
First Author: Skirzewski M
Year: 2018
Journal: Mol Psychiatry
Title: ErbB4 signaling in dopaminergic axonal projections increases extracellular dopamine levels and regulates spatial/working memory behaviors.
Volume: 23
Issue: 11
Pages: 2227-2237
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Publication
19793984 | J:316875
First Author: Vullhorst D
Year: 2009
Journal: J Neurosci
Title: Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus.
Volume: 29
Issue: 39
Pages: 12255-64
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Publication
15470130 | J:132561
First Author: Stankovic K
Year: 2004
Journal: J Neurosci
Title: Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear.
Volume: 24
Issue: 40
Pages: 8651-61
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Publication
29559337 | J:269788
 
First Author: Olaya JC
Year: 2018
Journal: Behav Brain Res
Title: Schizophrenia-relevant behaviours of female mice overexpressing neuregulin 1 type III.
Volume: 353
Pages: 227-235
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Publication
28981869 | J:269890
First Author: Olaya JC
Year: 2018
Journal: Schizophr Bull
Title: Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in Mice.
Volume: 44
Issue: 4
Pages: 865-875
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Publication
24177178 | J:206603
First Author: Lee CY
Year: 2014
Journal: Cancer Res
Title: Neuregulin autocrine signaling promotes self-renewal of breast tumor-initiating cells by triggering HER2/HER3 activation.
Volume: 74
Issue: 1
Pages: 341-52
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Publication
34630277 | J:312683
 
First Author: Mòdol-Caballero G
Year: 2021
Journal: Front Neurol
Title: Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1G93A ALS Mice.
Volume: 12
Pages: 693309
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Publication
21334441 | J:177965
First Author: Benvegnù S
Year: 2011
Journal: Mol Cell Neurosci
Title: Aged PrP null mice show defective processing of neuregulins in the peripheral nervous system.
Volume: 47
Issue: 1
Pages: 28-35
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Publication
23100438 | J:192171
First Author: Liang C
Year: 2012
Journal: J Neurosci
Title: Erbin is required for myelination in regenerated axons after injury.
Volume: 32
Issue: 43
Pages: 15169-80
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Publication
9742126 | J:317053
First Author: Pinkas-Kramarski R
Year: 1998
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Title: ErbB tyrosine kinases and the two neuregulin families constitute a ligand-receptor network.
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Title: Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.
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First Author: Adilakshmi T
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Journal: J Neurosci
Title: A nuclear variant of ErbB3 receptor tyrosine kinase regulates ezrin distribution and Schwann cell myelination.
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