PIN4, also known as Par14, is a member of the parvulin family of peptidyl-prolyl cis-trans isomerases. It is involved in rRNA processing, microtubule formation and the glucose metabolism []. It also binds DNA and associates with chromatin [].
This entry represents the RNA recognition motif (RRM) in Pin4, a novel phosphothreonine (pThr)-containing protein that specifically interacts with the pThr-binding site of the Rad53 FHA1 domain. Pin4 is involved in normal G2/M cell cycle progression in the absence of DNA damage and functions as a novel target of checkpoint-dependent cell cycle arrest pathways [, ]. It contains an N-terminal RRM, a nuclear localization signal, a coiled coil, and a total of 15 SQ/TQ motifs.In S. pombe, Cip1 (Csx1-interacting protein 1) and Cip2 (Csx1-interacting protein 2) are novel cytoplasmic RRM-containing proteins that counteract Csx1 function during oxidative stress. They are not essential for viability in S. pombe []. Both cip1 and cip2 contain one RRM. Like Pin4, Cip2 also possesses an R3H motif that may function in sequence-specific binding to single-stranded nucleic acids.
