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Search results 1601 to 1700 out of 1805 for Nedd4

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Type Details Score
Allele
Ndfip1<Gt(D068C12)Wrst> | MGI:3889629
 
Name: Nedd4 family interacting protein 1; gene trap D068C12, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Ndfip1<tm1.1Pmo> | MGI:5550254
Name: Nedd4 family interacting protein 1; targeted mutation 1.1, Paula M Oliver
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Allele
Ndfip1<tm1a(EUCOMM)Hmgu> | MGI:5295026
Name: Nedd4 family interacting protein 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
N4bp2l1<em1Gpt> | MGI:7302745
Name: NEDD4 binding protein 2-like 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Ndfip2<tm1b(EUCOMM)Hmgu> | MGI:5548666
Name: Nedd4 family interacting protein 2; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Ndfip1<tm1e(EUCOMM)Hmgu> | MGI:5294999
Name: Nedd4 family interacting protein 1; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Ndfip2<Gt(A014E02)Wrst> | MGI:4333095
 
Name: Nedd4 family interacting protein 2; gene trap A014E02, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Ndfip2<tm1a(EUCOMM)Hmgu> | MGI:4436082
Name: Nedd4 family interacting protein 2; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Genotype
Genotype
Symbol: Ndfip1/Ndfip1
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ndfip1/Ndfip1
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ndfip1/Ndfip1
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: N4bp1/N4bp1
Background: C57BL/6N-N4bp1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: N4bp1/N4bp1
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ndfip1/Ndfip1
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ndfip1/Ndfip1
Background: involves: C57BL/6J * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ndfip1/Ndfip1
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Publication
23851689 | J:205692
First Author: Ramos-Hernández N
Year: 2013
Journal: J Immunol
Title: Ndfip1 enforces a requirement for CD28 costimulation by limiting IL-2 production.
Volume: 191
Issue: 4
Pages: 1536-46
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Protein
Q9JLJ0
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Protein
Q9D7R2
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: false
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Publication
27786273 | J:242637
 
First Author: Yip KH
Year: 2016
Journal: Nat Commun
Title: The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation.
Volume: 7
Pages: 13198
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Publication
22417925 | -
First Author: Lackovic J
Year: 2012
Journal: Exp Neurol
Title: Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke.
Volume: 235
Issue: 1
Pages: 326-35
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Publication
12697834 | -
First Author: Vecchione A
Year: 2003
Journal: Mol Cell Biol
Title: The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor.
Volume: 23
Issue: 9
Pages: 3363-72
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Publication
18286479 | -
First Author: Monami G
Year: 2008
Journal: J Cell Physiol
Title: Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization.
Volume: 216
Issue: 2
Pages: 426-37
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Publication
12050153 | -
First Author: Konstas AA
Year: 2002
Journal: J Biol Chem
Title: Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein.
Volume: 277
Issue: 33
Pages: 29406-16
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Publication
32971525 | J:297419
First Author: Gitlin AD
Year: 2020
Journal: Nature
Title: Integration of innate immune signalling by caspase-8 cleavage of N4BP1.
Volume: 587
Issue: 7833
Pages: 275-280
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Publication
12730195 | J:121604
First Author: Watanabe N
Year: 2003
Journal: J Biol Chem
Title: Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination.
Volume: 278
Issue: 28
Pages: 26102-10
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Publication
18360097 | J:136919
First Author: Matsuoka T
Year: 2008
Journal: J Reprod Dev
Title: Identification of ZAG1, a novel protein expressed in mouse preimplantation, and its putative roles in zygotic genome activation.
Volume: 54
Issue: 3
Pages: 192-7
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Protein Coding Gene
MGI:1929512 | Litaf
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
28931009 | J:249835
First Author: Trimpert C
Year: 2017
Journal: PLoS One
Title: NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation.
Volume: 12
Issue: 9
Pages: e0183774
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Strain
MGI:5700681 | C57BL/6N-N4bp3<tm1b(KOMP)Mbp>/Ucd
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6768560 | C57BL/6JGpt-N4bp2l2<em3Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6768559 | C57BL/6JGpt-N4bp2l2<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6392821 | C57BL/6-Ndfip2<tm1.1Pmo>/J
Attribute String: targeted mutation, mutant strain, coisogenic
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Strain
MGI:6768586 | C57BL/6JGpt-Ndfip2<em5Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6768587 | C57BL/6JGpt-Ndfip2<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6768557 | C57BL/6JGpt-N4bp2l1<em5Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6392819 | C57BL/6-Ndfip1<tm1.1Pmo>/J
Attribute String: coisogenic, mutant strain, targeted mutation
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Strain
MGI:6768558 | C57BL/6JGpt-N4bp2l1<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:5557483 | C57BL/6N-Ndfip2<tm1b(EUCOMM)Hmgu>/3Ieg
Attribute String: coisogenic, targeted mutation
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Strain
MGI:5557484 | C57BL/6N-Ndfip2<tm1b(EUCOMM)Hmgu>/2Ieg
Attribute String: coisogenic, targeted mutation
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Strain
MGI:5557871 | C57BL/6N-Ndfip2<tm1b(EUCOMM)Hmgu>/Ieg
Attribute String: coisogenic, targeted mutation
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Strain
MGI:5556471 | C57BL/6N-Ndfip2<tm1a(EUCOMM)Hmgu>/Ieg
Attribute String: mutant strain, targeted mutation, coisogenic
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Strain
MGI:5806243 | C57BL/6N-Ndfip2<tm1a(EUCOMM)Hmgu>
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Ndfip1/Ndfip1 Tg(Nes-cre)1Kln/?
Background: involves: C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd28/Cd28 Ndfip1/Ndfip1
Background: involves: 129P2/OlaHsd * 129S2/SvPas
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ndfip2/Ndfip2
Background: C57BL/6N-Ndfip2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ndfip2/Ndfip2
Background: C57BL/6N-Ndfip2/Ieg
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ndfip1/Ndfip1 Tg(Nes-cre)1Kln/?
Background: involves: C57BL/6J * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: N4bp3/N4bp3
Background: C57BL/6N-N4bp3/Ucd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: N4bp3/N4bp3
Background: C57BL/6N-N4bp3/Ucd
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:6344600 | C57BL/6N-A<tm1Brd> N4bp3<tm1a(KOMP)Mbp>/MbpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6344601 | C57BL/6N-A<tm1Brd> N4bp3<tm1b(KOMP)Mbp>/MbpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Il4/Il4 Ndfip1/Ndfip1
Background: involves: 129P2/OlaHsd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ndfip1/Ndfip1 Tg(Cd4-cre)1Cwi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: N4bp3/N4bp3<+>
Background: C57BL/6N-N4bp3/Ucd
Zygosity: ht
Has Mutant Allele: true
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Protein
Q8C7U1
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
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Protein
A2AA66
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: true
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Protein
A2AA65
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
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Protein
A4FUQ1
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
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Publication
24044555 | -
 
First Author: Schmeisser MJ
Year: 2013
Journal: Neural Dev
Title: The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons.
Volume: 8
Pages: 18
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Protein Domain
IPR033571 | N4BP3
Type: Family
Description: N4BP3 was identified as a protein expressed during development that interacts with Nedd4 ubiquitin ligase. N4BP3 is not a ubiquitylation substrate of Nedd4, but it can alter Nedd4 subcellular location, indicating a functional interaction []. N4BP3 has been shown to be essential in neurite branching and circuit formation [].
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Publication
20233849 | J:159635
First Author: Sharma P
Year: 2010
Journal: J Cell Sci
Title: N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies.
Volume: 123
Issue: Pt 8
Pages: 1227-34
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Genotype
Genotype
Symbol: Ndfip1/Ndfip1 Rag1/Rag1 Tg(TcraTcrb)425Cbn/?
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Emx1/Emx1<+> Ndfip1/Ndfip1
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Publication
22733818 | J:286941
First Author: Glowacka WK
Year: 2012
Journal: J Biol Chem
Title: LAPTM5 protein is a positive regulator of proinflammatory signaling pathways in macrophages.
Volume: 287
Issue: 33
Pages: 27691-702
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Protein
Q3KQN1
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: true
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Protein
Q3UBS1
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
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Publication
19343052 | -
First Author: Mund T
Year: 2009
Journal: EMBO Rep
Title: Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.
Volume: 10
Issue: 5
Pages: 501-7
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Publication
17429078 | -
First Author: Sullivan JA
Year: 2007
Journal: Mol Biol Cell
Title: Multiple interactions drive adaptor-mediated recruitment of the ubiquitin ligase rsp5 to membrane proteins in vivo and in vitro.
Volume: 18
Issue: 7
Pages: 2429-40
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Publication
9115231 | -
First Author: Liu XF
Year: 1997
Journal: J Biol Chem
Title: Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene.
Volume: 272
Issue: 18
Pages: 11763-9
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Protein Domain
IPR019325 | NEDD4/Bsd2
Type: Family
Description: Proteins in this entry include the human NEDD4 family-interacting protein 1/2 (Ndfip1 and Ndfip2) and the yeast Bsd2 metal homeostatis proteins. Ndfip1 and Ndfip2 are endosomal membrane proteins that bind to and activate members of the Nedd4 family of E3 ubiquitin ligases [, ]. Ndfip1 plays a role in regulating metal transport in human neurons []. Bsd2 is required for the targeting of several proteins into the MVB (multivesicular body) pathway []. It prevents metal hyperaccumulation by exerting negative control over the Smf1 and Smf2 metal transport systems [].
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Publication
26555021 | -
First Author: Koshizuka T
Year: 2016
Journal: J Gen Virol
Title: Degradation of host ubiquitin E3 ligase Itch by human cytomegalovirus UL42.
Volume: 97
Issue: 1
Pages: 196-208
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Protein Domain
IPR035110 | UL42
Type: Family
Description: Members of this family include UL42 proteins found in Human cytomegalovirus (HCMV). UL42 has two Pro-Pro-X-Tyr (PPxY) sequences, a hydrophobic region at the C terminus and no N-terminal signal peptide. These features are shared with herpes simplex virus (HSV) UL56. UL42 has a putative C-terminal trans-membrane region. HCMV UL42 interacts with Itch, a member of the Nedd4 family of ubiquitin E3 ligases, through its PY motifs as observed in HSV UL56, suggestive of a regulatory function [].
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Publication
20519653 | J:161622
First Author: Ouchida R
Year: 2010
Journal: J Immunol
Title: A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation.
Volume: 185
Issue: 1
Pages: 294-301
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Publication
18619870 | J:137841
First Author: Ouchida R
Year: 2008
Journal: Immunity
Title: A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation.
Volume: 29
Issue: 1
Pages: 33-43
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Publication
17116753 | -
First Author: Pak Y
Year: 2006
Journal: J Cell Biol
Title: Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination.
Volume: 175
Issue: 4
Pages: 631-45
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Protein Domain
IPR018397 | Lysosomal-assoc_TM_prot5
Type: Family
Description: The lysosome associated protein transmembrane (LAPTM) family is comprised of three members: LAPTM5, LAPTM4a and LAPTM4b; they are lysosome-associated transmembrane proteins, found in mammals, insects and nematodes.This entry represents LAPTM5, which is a lysosomal protein expressed in cells of lymphoid and myeloid origin. LAPTM5 trafficking from the Golgi to the lysosome requires its association with the ubiquitin ligase Nedd4 and the clathrin adaptor GGA3 []. LAPTM5 negatively regulates T and B cell receptor signaling by directly interacting with these receptors and mediating their down-regulation [, ]. It is also a positive regulator of NF-kB and MAPK signaling allowing efficient proinflammatory cytokine production in response to macrophage activation [].
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Protein Coding Gene
MGI:1929597 | Bean1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0031439 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034001 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033982 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033909 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033687 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1929597 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033017 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033661 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033815 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033762 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033906 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033804 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034514 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032718 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033130 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023036 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032556 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
15314237 | J:92442
First Author: Nassar MA
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain.
Volume: 101
Issue: 34
Pages: 12706-11
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Protein
Q3U2D0
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
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Protein
B1ASF7
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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