Type |
Details |
Score |
Genotype |
Symbol: |
Apoe/Apoe Zbtb20/? |
Background: |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Pin1/Pin1 |
Background: |
involves: 129 * 129P2/OlaHsd * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Agrn/Agrn Tg(APPswe,PSEN1dE9)85Dbo/? Tg(Tek-cre)1Ywa/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APPswe,PSEN1dE9)85Dbo/? Tg(MGS1-19375/CFP)2R9Rwb/? |
Background: |
involves: C3H * C57BL/6 * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Flot1/Flot1 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? |
Background: |
involves: C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Flot1/Flot1 Flot2/Flot2 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Psen1/Psen1<+> Zbtb20/? |
Background: |
involves: 129 * C57BL/6 * C57BL/6J * DBA/2 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
App/App Klk7/Klk7 |
Background: |
involves: C57BL/6NTac |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rtn3/Rtn3 Tg(APPswe,PSEN1dE9)85Dbo/? |
Background: |
involves: 129S6/SvEvTac * C3H * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Culvenor JG |
Year: |
2004 |
Journal: |
Eur J Biochem |
Title: |
Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations. |
Volume: |
271 |
Issue: |
2 |
Pages: |
375-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sachse CC |
Year: |
2013 |
Journal: |
FASEB J |
Title: |
BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels. |
Volume: |
27 |
Issue: |
6 |
Pages: |
2458-67 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 152H, Laurence Ozmen |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APPSWE)2576Kha/? |
Background: |
involves: C57BL/6 * SJL |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Eno2-APPSwe)1223-3Ykk/? |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Bace1/Bace1 Nrg1/Nrg1<+> |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Bace1/Bace1<+> Tg(Camk2a-tTA)1Mmay/? Tg(tetO-CDK5R1/GFP)337Lht/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
amyloid beta precursor protein; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
amyloid beta precursor protein; targeted mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
App/App |
Background: |
involves: C57BL/6JSmoc |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Iyaswamy A |
Year: |
2023 |
Journal: |
Signal Transduct Target Ther |
Title: |
Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease. |
Volume: |
8 |
Issue: |
1 |
Pages: |
404 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 18, David R Borchelt |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inducible, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion A2, Frank M LaFerla |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion A6, Frank M LaFerla |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(PDGFB-APPSweIndArc)48Lms/? |
Background: |
B6.Cg-Tg(PDGFB-APPSweIndArc)48Lms |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Thy1-APPLon)2Vln/? Tg(Thy1-PSEN1*A246E)2Vln/? |
Background: |
involves: FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? |
Background: |
involves: C57BL/6 * SJL |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? Tg(Thy1-MAPT*)30Schd/? |
Background: |
involves: C57BL/6 * C57BL/6J * CBA * SJL |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Shen X |
Year: |
2016 |
Journal: |
eNeuro |
Title: |
Neurons in Vulnerable Regions of the Alzheimer's Disease Brain Display Reduced ATM Signaling. |
Volume: |
3 |
Issue: |
1 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sapkota D |
Year: |
2022 |
Journal: |
Brain |
Title: |
Aqp4 stop codon readthrough facilitates amyloid-β clearance from the brain. |
Volume: |
145 |
Issue: |
9 |
Pages: |
2982-2990 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guzmán EA |
Year: |
2014 |
Journal: |
Mol Neurodegener |
Title: |
Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease. |
Volume: |
9 |
|
Pages: |
13 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Eno2-APP*Ind)#Kakiz/Tg(Eno2-APP*Ind)#Kakiz |
Background: |
involves: C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APP695)3Dbo/? |
Background: |
involves: C3H/HeJ * C57BL/6J |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APP695)3Dbo/? |
Background: |
B6.C3-Tg(APP695)3Dbo |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APPV717F)109Ili/Tg(APPV717F)109Ili |
Background: |
Not Specified |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Thy1-APPLon)2Vln/? |
Background: |
involves: C57BL/6 * CBA * FVB/N |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APPV717F)109Ili/? |
Background: |
involves: BALB/c * C57BL * C57BL/6NTac |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APPSWE)2576Kha/? Tg(PSEN1)5Dbo/? |
Background: |
involves: C57BL/6 * SJL |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Klc1/Klc1<+> Tg(APP695)3Dbo/? |
Background: |
involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gsk3a/Gsk3a Tg(APPV717F)109Ili/? Tg(Camk2a-cre)#Stl/? |
Background: |
involves: BALB/c * C57BL * C57BL/6NTac |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Arbogast T |
Year: |
2015 |
Journal: |
Dis Model Mech |
Title: |
Deletion of the App-Runx1 region in mice models human partial monosomy 21. |
Volume: |
8 |
Issue: |
6 |
Pages: |
623-34 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 6799, Robert Vassar |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 3, David R Borchelt |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Ckm-APPSw)A2Lfa/? |
Background: |
involves: C57BL/6 * SJL |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Thy1-APPSweLon)41Ema/? |
Background: |
involves: C57BL/6 * DBA/2 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Beher D |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. |
Volume: |
271 |
Issue: |
3 |
Pages: |
1613-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sturr MG |
Year: |
1996 |
Journal: |
J Bacteriol |
Title: |
Purification of a cytochrome bd terminal oxidase encoded by the Escherichia coli app locus from a delta cyo delta cyd strain complemented by genes from Bacillus firmus OF4. |
Volume: |
178 |
Issue: |
6 |
Pages: |
1742-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reiserer RS |
Year: |
2007 |
Journal: |
Genes Brain Behav |
Title: |
Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease. |
Volume: |
6 |
Issue: |
1 |
Pages: |
54-65 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? |
Background: |
involves: C57BL/6 * SJL |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? Tg(Prnp-MAPT*P301S)PS19Vle/? |
Background: |
B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas Tg(Prnp-MAPT*P301S)PS19Vle |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas |
Background: |
B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Deyts C |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model. |
Volume: |
27 |
Issue: |
5 |
Pages: |
1345-1355.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brower CS |
Year: |
2013 |
Journal: |
Mol Cell |
Title: |
Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway. |
Volume: |
50 |
Issue: |
2 |
Pages: |
161-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Du H |
Year: |
2021 |
Journal: |
Life Sci Alliance |
Title: |
A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses. |
Volume: |
4 |
Issue: |
7 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Lee HJ |
Year: |
2021 |
Journal: |
Aging Cell |
Title: |
Ibrutinib modulates Aβ/tau pathology, neuroinflammation, and cognitive function in mouse models of Alzheimer's disease. |
Volume: |
20 |
Issue: |
3 |
Pages: |
e13332 |
|
•
•
•
•
•
|
Publication |
First Author: |
Park M |
Year: |
2025 |
Journal: |
Theranostics |
Title: |
Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer's disease mouse model. |
Volume: |
15 |
Issue: |
2 |
Pages: |
428-438 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Z |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. |
Volume: |
8 |
|
Pages: |
14740 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wickham L |
Year: |
2005 |
Journal: |
J Neurochem |
Title: |
Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. |
Volume: |
92 |
Issue: |
1 |
Pages: |
93-102 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 2576, Karen Hsiao Ashe |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 96, Bruce Lamb |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Clu/Clu Tg(APPV717F)109Ili/Tg(APPV717F)109Ili |
Background: |
involves: 129S2/SvPas |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Psen1/Psen1 Tg(APPSWE)2576Kha/? |
Background: |
involves: C57BL/6 * C57BL/6J * SJL |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Apoe/Apoe Tg(APPSWE)2576Kha/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * SJL |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 19959, David Westaway |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Hou Y |
Year: |
2010 |
Journal: |
Neuropharmacology |
Title: |
Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice. |
Volume: |
58 |
Issue: |
6 |
Pages: |
911-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Song JX |
Year: |
2020 |
Journal: |
Aging Cell |
Title: |
A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. |
Volume: |
19 |
Issue: |
2 |
Pages: |
e13069 |
|
•
•
•
•
•
|
Publication |
First Author: |
Login H |
Year: |
2015 |
Journal: |
Brain Struct Funct |
Title: |
Activity-dependent and graded BACE1 expression in the olfactory epithelium is mediated by the retinoic acid metabolizing enzyme CYP26B1. |
Volume: |
220 |
Issue: |
4 |
Pages: |
2143-57 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Roger M Nitsch |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APP)6209Kha/? |
Background: |
FVB/N-Tg(APP)6209Kha |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Josephine Nalbantoglu |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion M8, Caroline Graff |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Psen1/Psen1 Tg(Thy1-APP)28Lpr/? |
Background: |
either: 129/Sv or (involves: 129/Sv * C57BL/6) |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang M |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Acute restraint stress reverses impaired LTP in the hippocampal CA1 region in mouse models of Alzheimer's disease. |
Volume: |
9 |
Issue: |
1 |
Pages: |
10955 |
|
•
•
•
•
•
|
Publication |
First Author: |
Byun J |
Year: |
2015 |
Journal: |
Cell Death Differ |
Title: |
CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease. |
Volume: |
22 |
Issue: |
6 |
Pages: |
959-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Son SM |
Year: |
2015 |
Journal: |
Neurobiol Aging |
Title: |
Thrombospondin-1 prevents amyloid beta-mediated synaptic pathology in Alzheimer's disease. |
Volume: |
36 |
Issue: |
12 |
Pages: |
3214-3227 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2023 |
Journal: |
Alzheimers Res Ther |
Title: |
Attenuation of Alzheimer's brain pathology in 5XFAD mice by PTH(1-34), a peptide of parathyroid hormone. |
Volume: |
15 |
Issue: |
1 |
Pages: |
53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Durrant CS |
Year: |
2020 |
Journal: |
Cell Death Dis |
Title: |
Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling. |
Volume: |
11 |
Issue: |
2 |
Pages: |
98 |
|
•
•
•
•
•
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Publication |
First Author: |
Tataryn NM |
Year: |
2021 |
Journal: |
Neurobiol Aging |
Title: |
Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease. |
Volume: |
107 |
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Pages: |
96-108 |
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Publication |
First Author: |
Neddens J |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models. |
Volume: |
15 |
Issue: |
7 |
Pages: |
e0235543 |
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Publication |
First Author: |
Ohno M |
Year: |
2009 |
Journal: |
Nat Neurosci |
Title: |
Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system. |
Volume: |
12 |
Issue: |
12 |
Pages: |
1506-13 |
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Publication |
First Author: |
Tüshaus J |
Year: |
2021 |
Journal: |
FASEB J |
Title: |
The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system. |
Volume: |
35 |
Issue: |
11 |
Pages: |
e21962 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
64
 |
Fragment?: |
true |
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Protein Domain |
Type: |
Family |
Description: |
This family includes calsyntenin 1/2/3 (also known as alcadein-alpha/beta/gamma). They are single-pass type I membrane proteins that may modulate calcium-mediated postsynaptic signals [].CLSTN (also known as Alc) forms a tripartite complex with APP (amyloid beta-protein precursor) and X11L (a neuron-specific adaptor protein) in brain; this complex stabilizes both APP and CLSTN proteins metabolically. Deficiencies in the X11L-mediated interaction between CLSTN and APP and/or CTFbeta enhances the production of amyloid beta-protein and have been linked to the development or progression of Alzheimer's disease []. Moreover, CLSTN1 strongly associates with kinesin-1 light chains (KLC1) and acts as a cargo that regulates kinesin-1 function. It may affect the transport of APP-containing vesicles by kinesin-1 []. |
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Publication |
First Author: |
Singer O |
Year: |
2005 |
Journal: |
Nat Neurosci |
Title: |
Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. |
Volume: |
8 |
Issue: |
10 |
Pages: |
1343-9 |
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Publication |
First Author: |
De Rossi P |
Year: |
2019 |
Journal: |
Brain Pathol |
Title: |
Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models. |
Volume: |
29 |
Issue: |
4 |
Pages: |
485-501 |
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Publication |
First Author: |
Cui Y |
Year: |
2011 |
Journal: |
Am J Pathol |
Title: |
Genetic ablation of apolipoprotein A-IV accelerates Alzheimer's disease pathogenesis in a mouse model. |
Volume: |
178 |
Issue: |
3 |
Pages: |
1298-308 |
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Publication |
First Author: |
Wang M |
Year: |
2024 |
Journal: |
Biochim Biophys Acta Mol Basis Dis |
Title: |
GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease. |
Volume: |
1870 |
Issue: |
4 |
Pages: |
167093 |
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Publication |
First Author: |
Sesele K |
Year: |
2013 |
Journal: |
Aging Cell |
Title: |
Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model. |
Volume: |
12 |
Issue: |
6 |
Pages: |
1032-40 |
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Publication |
First Author: |
Kalovyrna N |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
A 3'UTR modification of the TNF-α mouse gene increases peripheral TNF-α and modulates the Alzheimer-like phenotype in 5XFAD mice. |
Volume: |
10 |
Issue: |
1 |
Pages: |
8670 |
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Publication |
First Author: |
Baranger K |
Year: |
2016 |
Journal: |
Cell Mol Life Sci |
Title: |
MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease. |
Volume: |
73 |
Issue: |
1 |
Pages: |
217-36 |
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Publication |
First Author: |
Burgert T |
Year: |
2013 |
Journal: |
Mol Cell Biol |
Title: |
SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. |
Volume: |
33 |
Issue: |
21 |
Pages: |
4308-20 |
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Publication |
First Author: |
Zhang J |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease. |
Volume: |
34 |
Issue: |
45 |
Pages: |
14919-33 |
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Publication |
First Author: |
Illouz T |
Year: |
2021 |
Journal: |
Commun Biol |
Title: |
Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis. |
Volume: |
4 |
Issue: |
1 |
Pages: |
329 |
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Publication |
First Author: |
Song H |
Year: |
2013 |
Journal: |
Cell Death Differ |
Title: |
Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis. |
Volume: |
20 |
Issue: |
4 |
Pages: |
639-48 |
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Publication |
First Author: |
Qiu Y |
Year: |
2022 |
Journal: |
Front Aging Neurosci |
Title: |
Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer's disease risk. |
Volume: |
14 |
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Pages: |
896522 |
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Publication |
First Author: |
Mabrouk R |
Year: |
2023 |
Journal: |
Neurobiol Dis |
Title: |
Most dystrophic neurites in the common 5xFAD Alzheimer mouse model originate from axon terminals. |
Volume: |
182 |
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Pages: |
106150 |
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Publication |
First Author: |
Son Y |
Year: |
2023 |
Journal: |
Int J Radiat Biol |
Title: |
Low-dose-rate ionizing radiation affects innate immunity protein IFITM3 in a mouse model of Alzheimer's disease. |
Volume: |
99 |
Issue: |
11 |
Pages: |
1649-1659 |
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