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Search results 2301 to 2400 out of 7122 for App

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Type Details Score
Genotype
Symbol: Apoe/Apoe Zbtb20/?
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Pin1/Pin1
Background: involves: 129 * 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Agrn/Agrn Tg(APPswe,PSEN1dE9)85Dbo/? Tg(Tek-cre)1Ywa/?
Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(APPswe,PSEN1dE9)85Dbo/? Tg(MGS1-19375/CFP)2R9Rwb/?
Background: involves: C3H * C57BL/6 * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Flot1/Flot1 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: involves: C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Flot1/Flot1 Flot2/Flot2 Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Psen1/Psen1<+> Zbtb20/?
Background: involves: 129 * C57BL/6 * C57BL/6J * DBA/2
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: App/App Klk7/Klk7
Background: involves: C57BL/6NTac
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Rtn3/Rtn3 Tg(APPswe,PSEN1dE9)85Dbo/?
Background: involves: 129S6/SvEvTac * C3H * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Culvenor JG
Year: 2004
Journal: Eur J Biochem
Title: Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.
Volume: 271
Issue: 2
Pages: 375-85
Publication
First Author: Sachse CC
Year: 2013
Journal: FASEB J
Title: BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels.
Volume: 27
Issue: 6
Pages: 2458-67
Allele
Name: transgene insertion 152H, Laurence Ozmen
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Tg(APPSWE)2576Kha/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Eno2-APPSwe)1223-3Ykk/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Bace1/Bace1 Nrg1/Nrg1<+>
Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/cJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Bace1/Bace1<+> Tg(Camk2a-tTA)1Mmay/? Tg(tetO-CDK5R1/GFP)337Lht/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Allele
Name: amyloid beta precursor protein; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Strain
Attribute String: coisogenic, mutant strain, targeted mutation
Allele
Name: amyloid beta precursor protein; targeted mutation 2, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Genotype
Symbol: App/App
Background: involves: C57BL/6JSmoc
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Iyaswamy A
Year: 2023
Journal: Signal Transduct Target Ther
Title: Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease.
Volume: 8
Issue: 1
Pages: 404
Allele
Name: transgene insertion 18, David R Borchelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
Allele
Name: transgene insertion A2, Frank M LaFerla
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion A6, Frank M LaFerla
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Genotype
Symbol: Tg(PDGFB-APPSweIndArc)48Lms/?
Background: B6.Cg-Tg(PDGFB-APPSweIndArc)48Lms
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Thy1-APPLon)2Vln/? Tg(Thy1-PSEN1*A246E)2Vln/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? Tg(Thy1-MAPT*)30Schd/?
Background: involves: C57BL/6 * C57BL/6J * CBA * SJL
Zygosity: cx
Has Mutant Allele: true
Publication  
First Author: Shen X
Year: 2016
Journal: eNeuro
Title: Neurons in Vulnerable Regions of the Alzheimer's Disease Brain Display Reduced ATM Signaling.
Volume: 3
Issue: 1
Publication
First Author: Sapkota D
Year: 2022
Journal: Brain
Title: Aqp4 stop codon readthrough facilitates amyloid-β clearance from the brain.
Volume: 145
Issue: 9
Pages: 2982-2990
Publication  
First Author: Guzmán EA
Year: 2014
Journal: Mol Neurodegener
Title: Abundance of Aβ₅-x like immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer's disease.
Volume: 9
Pages: 13
Genotype
Symbol: Tg(Eno2-APP*Ind)#Kakiz/Tg(Eno2-APP*Ind)#Kakiz
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(APP695)3Dbo/?
Background: involves: C3H/HeJ * C57BL/6J
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(APP695)3Dbo/?
Background: B6.C3-Tg(APP695)3Dbo
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Tg(Thy1-APPLon)2Vln/?
Background: involves: C57BL/6 * CBA * FVB/N
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(APPV717F)109Ili/?
Background: involves: BALB/c * C57BL * C57BL/6NTac
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(APPSWE)2576Kha/? Tg(PSEN1)5Dbo/?
Background: involves: C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Klc1/Klc1<+> Tg(APP695)3Dbo/?
Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Gsk3a/Gsk3a Tg(APPV717F)109Ili/? Tg(Camk2a-cre)#Stl/?
Background: involves: BALB/c * C57BL * C57BL/6NTac
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Arbogast T
Year: 2015
Journal: Dis Model Mech
Title: Deletion of the App-Runx1 region in mice models human partial monosomy 21.
Volume: 8
Issue: 6
Pages: 623-34
Allele
Name: transgene insertion 6799, Robert Vassar
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion 3, David R Borchelt
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Tg(Ckm-APPSw)A2Lfa/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Thy1-APPSweLon)41Ema/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Beher D
Year: 1996
Journal: J Biol Chem
Title: Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.
Volume: 271
Issue: 3
Pages: 1613-20
Publication
First Author: Sturr MG
Year: 1996
Journal: J Bacteriol
Title: Purification of a cytochrome bd terminal oxidase encoded by the Escherichia coli app locus from a delta cyo delta cyd strain complemented by genes from Bacillus firmus OF4.
Volume: 178
Issue: 6
Pages: 1742-9
Publication
First Author: Reiserer RS
Year: 2007
Journal: Genes Brain Behav
Title: Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.
Volume: 6
Issue: 1
Pages: 54-65
Genotype
Symbol: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/? Tg(Prnp-MAPT*P301S)PS19Vle/?
Background: B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas Tg(Prnp-MAPT*P301S)PS19Vle
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas
Background: B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Deyts C
Year: 2019
Journal: Cell Rep
Title: APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.
Volume: 27
Issue: 5
Pages: 1345-1355.e6
Publication
First Author: Brower CS
Year: 2013
Journal: Mol Cell
Title: Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.
Volume: 50
Issue: 2
Pages: 161-71
Publication  
First Author: Du H
Year: 2021
Journal: Life Sci Alliance
Title: A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses.
Volume: 4
Issue: 7
Publication
First Author: Lee HJ
Year: 2021
Journal: Aging Cell
Title: Ibrutinib modulates Aβ/tau pathology, neuroinflammation, and cognitive function in mouse models of Alzheimer's disease.
Volume: 20
Issue: 3
Pages: e13332
Publication
First Author: Park M
Year: 2025
Journal: Theranostics
Title: Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer's disease mouse model.
Volume: 15
Issue: 2
Pages: 428-438
Publication  
First Author: Zhang Z
Year: 2017
Journal: Nat Commun
Title: Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease.
Volume: 8
Pages: 14740
Publication
First Author: Wickham L
Year: 2005
Journal: J Neurochem
Title: Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.
Volume: 92
Issue: 1
Pages: 93-102
Allele
Name: transgene insertion 2576, Karen Hsiao Ashe
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion 96, Bruce Lamb
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Clu/Clu Tg(APPV717F)109Ili/Tg(APPV717F)109Ili
Background: involves: 129S2/SvPas
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Psen1/Psen1 Tg(APPSWE)2576Kha/?
Background: involves: C57BL/6 * C57BL/6J * SJL
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Apoe/Apoe Tg(APPSWE)2576Kha/?
Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
Allele
Name: transgene insertion 19959, David Westaway
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Publication
First Author: Hou Y
Year: 2010
Journal: Neuropharmacology
Title: Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice.
Volume: 58
Issue: 6
Pages: 911-20
Publication
First Author: Song JX
Year: 2020
Journal: Aging Cell
Title: A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models.
Volume: 19
Issue: 2
Pages: e13069
Publication
First Author: Login H
Year: 2015
Journal: Brain Struct Funct
Title: Activity-dependent and graded BACE1 expression in the olfactory epithelium is mediated by the retinoic acid metabolizing enzyme CYP26B1.
Volume: 220
Issue: 4
Pages: 2143-57
Allele
Name: transgene insertion, Roger M Nitsch
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Tg(APP)6209Kha/?
Background: FVB/N-Tg(APP)6209Kha
Zygosity: ot
Has Mutant Allele: true
Allele
Name: transgene insertion, Josephine Nalbantoglu
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion M8, Caroline Graff
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Psen1/Psen1 Tg(Thy1-APP)28Lpr/?
Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)
Zygosity: cx
Has Mutant Allele: true
GO Term
GO Term
Publication
First Author: Wang M
Year: 2019
Journal: Sci Rep
Title: Acute restraint stress reverses impaired LTP in the hippocampal CA1 region in mouse models of Alzheimer's disease.
Volume: 9
Issue: 1
Pages: 10955
Publication
First Author: Byun J
Year: 2015
Journal: Cell Death Differ
Title: CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease.
Volume: 22
Issue: 6
Pages: 959-73
Publication
First Author: Son SM
Year: 2015
Journal: Neurobiol Aging
Title: Thrombospondin-1 prevents amyloid beta-mediated synaptic pathology in Alzheimer's disease.
Volume: 36
Issue: 12
Pages: 3214-3227
Publication
First Author: Chen L
Year: 2023
Journal: Alzheimers Res Ther
Title: Attenuation of Alzheimer's brain pathology in 5XFAD mice by PTH(1-34), a peptide of parathyroid hormone.
Volume: 15
Issue: 1
Pages: 53
Publication
First Author: Durrant CS
Year: 2020
Journal: Cell Death Dis
Title: Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling.
Volume: 11
Issue: 2
Pages: 98
Publication  
First Author: Tataryn NM
Year: 2021
Journal: Neurobiol Aging
Title: Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer's Disease.
Volume: 107
Pages: 96-108
Publication
First Author: Neddens J
Year: 2020
Journal: PLoS One
Title: Correlation of pyroglutamate amyloid β and ptau Ser202/Thr205 levels in Alzheimer's disease and related murine models.
Volume: 15
Issue: 7
Pages: e0235543
Publication
First Author: Ohno M
Year: 2009
Journal: Nat Neurosci
Title: Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system.
Volume: 12
Issue: 12
Pages: 1506-13
Publication
First Author: Tüshaus J
Year: 2021
Journal: FASEB J
Title: The pseudoprotease iRhom1 controls ectodomain shedding of membrane proteins in the nervous system.
Volume: 35
Issue: 11
Pages: e21962
Protein
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
Protein Domain
Type: Family
Description: This family includes calsyntenin 1/2/3 (also known as alcadein-alpha/beta/gamma). They are single-pass type I membrane proteins that may modulate calcium-mediated postsynaptic signals [].CLSTN (also known as Alc) forms a tripartite complex with APP (amyloid beta-protein precursor) and X11L (a neuron-specific adaptor protein) in brain; this complex stabilizes both APP and CLSTN proteins metabolically. Deficiencies in the X11L-mediated interaction between CLSTN and APP and/or CTFbeta enhances the production of amyloid beta-protein and have been linked to the development or progression of Alzheimer's disease []. Moreover, CLSTN1 strongly associates with kinesin-1 light chains (KLC1) and acts as a cargo that regulates kinesin-1 function. It may affect the transport of APP-containing vesicles by kinesin-1 [].
Publication
First Author: Singer O
Year: 2005
Journal: Nat Neurosci
Title: Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.
Volume: 8
Issue: 10
Pages: 1343-9
Publication
First Author: De Rossi P
Year: 2019
Journal: Brain Pathol
Title: Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.
Volume: 29
Issue: 4
Pages: 485-501
Publication
First Author: Cui Y
Year: 2011
Journal: Am J Pathol
Title: Genetic ablation of apolipoprotein A-IV accelerates Alzheimer's disease pathogenesis in a mouse model.
Volume: 178
Issue: 3
Pages: 1298-308
Publication
First Author: Wang M
Year: 2024
Journal: Biochim Biophys Acta Mol Basis Dis
Title: GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease.
Volume: 1870
Issue: 4
Pages: 167093
Publication
First Author: Sesele K
Year: 2013
Journal: Aging Cell
Title: Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.
Volume: 12
Issue: 6
Pages: 1032-40
Publication
First Author: Kalovyrna N
Year: 2020
Journal: Sci Rep
Title: A 3'UTR modification of the TNF-α mouse gene increases peripheral TNF-α and modulates the Alzheimer-like phenotype in 5XFAD mice.
Volume: 10
Issue: 1
Pages: 8670
Publication
First Author: Baranger K
Year: 2016
Journal: Cell Mol Life Sci
Title: MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.
Volume: 73
Issue: 1
Pages: 217-36
Publication
First Author: Burgert T
Year: 2013
Journal: Mol Cell Biol
Title: SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes.
Volume: 33
Issue: 21
Pages: 4308-20
Publication
First Author: Zhang J
Year: 2014
Journal: J Neurosci
Title: Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease.
Volume: 34
Issue: 45
Pages: 14919-33
Publication
First Author: Illouz T
Year: 2021
Journal: Commun Biol
Title: Maternal antibodies facilitate Amyloid-β clearance by activating Fc-receptor-Syk-mediated phagocytosis.
Volume: 4
Issue: 1
Pages: 329
Publication
First Author: Song H
Year: 2013
Journal: Cell Death Differ
Title: Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis.
Volume: 20
Issue: 4
Pages: 639-48
Publication  
First Author: Qiu Y
Year: 2022
Journal: Front Aging Neurosci
Title: Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer's disease risk.
Volume: 14
Pages: 896522
Publication  
First Author: Mabrouk R
Year: 2023
Journal: Neurobiol Dis
Title: Most dystrophic neurites in the common 5xFAD Alzheimer mouse model originate from axon terminals.
Volume: 182
Pages: 106150
Publication
First Author: Son Y
Year: 2023
Journal: Int J Radiat Biol
Title: Low-dose-rate ionizing radiation affects innate immunity protein IFITM3 in a mouse model of Alzheimer's disease.
Volume: 99
Issue: 11
Pages: 1649-1659