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Search results 1301 to 1400 out of 1419 for Ptk2

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Hits by Pathway

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Type Details Score
Strain
MGI:6429445 | C57BL/6J-Ptk2b<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7469307 | C57BL/6JGpt-Ptk2b<em4Gpt>/Gpt
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6771089 | C57BL/6J-Ptk2b<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Ptk2b/Ptk2b
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: CBA.Cg-Ptk2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: involves: C57BL/6 * CBA
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(Tek-cre)1Rwng/?
Background: involves: 129X1/SvJ * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(Nes-cre)1Sasa/?
Background: B6.Cg-Ptk2 Tg(Nes-cre)1Sasa
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2b/Ptk2b
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: B6.129P2-Ptk2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(Tek-cre)12Flv/?
Background: involves: 129P2/OlaHsd * C3H * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: involves: 129S/SvEv * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: involves: 129S/SvEv * C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(MMTV-PyVT)634Mul/?
Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2b/Ptk2b
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2b/Ptk2b
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2
Background: involves: 129X1/SvJ * CD-1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2b/Ptk2b
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
34529077 | J:326577
First Author: Zheng J
Year: 2022
Journal: J Mol Cell Biol
Title: Pyk2 suppresses contextual fear memory in an autophosphorylation-independent manner.
Volume: 13
Issue: 11
Pages: 808-821
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Publication
25349423 | J:216771
First Author: Kinoshita Y
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress.
Volume: 111
Issue: 45
Pages: 16130-5
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Publication
29911975 | J:264145
   
First Author: Fan L
Year: 2018
Journal: Elife
Title: Alpha protocadherins and Pyk2 kinase regulate cortical neuron migration and cytoskeletal dynamics via Rac1 GTPase and WAVE complex in mice.
Volume: 7
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Protein Coding Gene
MGI:96602 | Itga3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96600 | Itga2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q62469
Organism: Mus musculus/domesticus
Length: 1178  
Fragment?: false
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Protein
Q62470
Organism: Mus musculus/domesticus
Length: 1053  
Fragment?: false
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Strain
MGI:6344787 | C57BL/6N-A<tm1Brd> Ptk2<tm1a(KOMP)Wtsi>/MbpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(KRT14-cre/ERT2)1Ipc/?
Background: involves: 129P2/OlaHsd * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2<+>
Background: involves: 129S/SvEv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Publication
12771146 | J:230354
First Author: Kruljac-Letunic A
Year: 2003
Journal: J Biol Chem
Title: The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1.
Volume: 278
Issue: 32
Pages: 29560-70
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Publication
7499242 | J:29773
First Author: Avraham S
Year: 1995
Journal: J Biol Chem
Title: Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain.
Volume: 270
Issue: 46
Pages: 27742-51
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Publication
11238453 | J:67886
First Author: Ren XR
Year: 2001
Journal: J Cell Biol
Title: Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein.
Volume: 152
Issue: 5
Pages: 971-84
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Publication
14739300 | J:89495
First Author: Miyazaki T
Year: 2004
Journal: J Biol Chem
Title: Src kinase activity is essential for osteoclast function.
Volume: 279
Issue: 17
Pages: 17660-6
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Publication
26642240 | J:231935
First Author: Jabara HH
Year: 2016
Journal: Nat Genet
Title: A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
Volume: 48
Issue: 1
Pages: 74-8
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Publication
20727793 | J:163910
First Author: Davidson D
Year: 2010
Journal: Immunity
Title: The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2.
Volume: 33
Issue: 2
Pages: 167-80
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Publication
22544749 | J:186506
First Author: Xu J
Year: 2012
Journal: J Biol Chem
Title: Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity.
Volume: 287
Issue: 25
Pages: 20942-56
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Publication
28385807 | J:243304
First Author: Soni D
Year: 2017
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca2+ entry regulates disassembly of adherens junctions.
Volume: 312
Issue: 6
Pages: L1003-L1017
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Publication
23589331 | J:204493
First Author: Rhee I
Year: 2013
Journal: Mol Cell Biol
Title: Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12.
Volume: 33
Issue: 12
Pages: 2458-69
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Publication
11274221 | J:79952
First Author: Andreev J
Year: 2001
Journal: J Biol Chem
Title: Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade.
Volume: 276
Issue: 23
Pages: 20130-5
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Publication
9988732 | J:53091
First Author: Lakkakorpi PT
Year: 1999
Journal: J Biol Chem
Title: Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone.
Volume: 274
Issue: 8
Pages: 4900-7
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Publication
15761030 | J:99228
First Author: Sekimoto H
Year: 2005
Journal: Mol Endocrinol
Title: (alpha)v(beta)3 integrins and Pyk2 mediate insulin-like growth factor I activation of Src and mitogen-activated protein kinase in 3T3-L1 cells.
Volume: 19
Issue: 7
Pages: 1859-67
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Publication
16546139 | J:107563
First Author: Guignandon A
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Cyclic strain promotes shuttling of PYK2/Hic-5 complex from focal contacts in osteoblast-like cells.
Volume: 343
Issue: 2
Pages: 407-14
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Publication
17684059 | J:128374
First Author: Faure C
Year: 2007
Journal: J Cell Sci
Title: Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons.
Volume: 120
Issue: Pt 17
Pages: 3034-44
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Publication
19380485 | J:149899
First Author: Bruzzaniti A
Year: 2009
Journal: Mol Cell Biol
Title: Dynamin reduces Pyk2 Y402 phosphorylation and SRC binding in osteoclasts.
Volume: 29
Issue: 13
Pages: 3644-56
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Publication
18483407 | J:151384
First Author: Fisslthaler B
Year: 2008
Journal: Circ Res
Title: Inhibition of endothelial nitric oxide synthase activity by proline-rich tyrosine kinase 2 in response to fluid shear stress and insulin.
Volume: 102
Issue: 12
Pages: 1520-8
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Publication
19841181 | J:157191
First Author: Pierau M
Year: 2009
Journal: J Immunol
Title: Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation.
Volume: 183
Issue: 10
Pages: 6124-34
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Publication
23711511 | J:202540
First Author: Martel-Gallegos G
Year: 2013
Journal: Biochim Biophys Acta
Title: Oxidative stress induced by P2X7 receptor stimulation in murine macrophages is mediated by c-Src/Pyk2 and ERK1/2.
Volume: 1830
Issue: 10
Pages: 4650-9
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Publication
27796369 | J:259915
 
First Author: Chung IC
Year: 2016
Journal: Sci Rep
Title: Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis.
Volume: 6
Pages: 36214
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Publication
32693110 | J:299443
First Author: Canino J
Year: 2020
Journal: Biochim Biophys Acta Mol Cell Res
Title: The proline-rich tyrosine kinase Pyk2 modulates integrin-mediated neutrophil adhesion and reactive oxygen species generation.
Volume: 1867
Issue: 10
Pages: 118799
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(Tek-cre)12Flv/?
Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(KRT5-cre)5132Jlj/?
Background: involves: 129X1/SvJ * C57BL/6 * CBA * DBA/2J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2<+>
Background: CBA.Cg-Ptk2
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fyn/Fyn Ptk2/Ptk2<+>
Background: involves: 129X1/SvJ * C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Tg(Tek-cre)12Flv/?
Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2<+>
Background: involves: C57BL/6 * CBA
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2 Trp53/Trp53
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Neurod6/Neurod6<+> Ptk2/Ptk2
Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:88447 | Col11a2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88446 | Col11a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919351 | Megf6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q64739
Organism: Mus musculus/domesticus
Length: 1736  
Fragment?: false
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Protein
Q80V70
Organism: Mus musculus/domesticus
Length: 1572  
Fragment?: false
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Protein
Q61245
Organism: Mus musculus/domesticus
Length: 1804  
Fragment?: false
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Publication
15786712 | J:180575
First Author: Watanabe N
Year: 2005
Journal: Mol Cell Biochem
Title: Leupaxin binds to PEST domain tyrosine phosphatase PEP.
Volume: 269
Issue: 1-2
Pages: 13-7
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Publication
25967238 | J:226138
First Author: Canobbio I
Year: 2015
Journal: Biochem J
Title: The focal adhesion kinase Pyk2 links Ca2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets.
Volume: 469
Issue: 2
Pages: 199-210
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Publication
19416922 | J:248211
First Author: Marqués M
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Specific function of phosphoinositide 3-kinase beta in the control of DNA replication.
Volume: 106
Issue: 18
Pages: 7525-30
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Strain
MGI:6446958 | B6.Cg-Apoe<tm1.1(APOE*4)Adiuj> Ptk2b<em1Adiuj> App<em1Adiuj> Trem2<em1Adiuj>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Myl2/Myl2<+> Ptk2/Ptk2
Background: involves: 129P2/OlaHsd * 129S4/SvJae
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ptk2/Ptk2<+> Trp53/Trp53
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI:88458 | Col5a2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88457 | Col5a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1858212 | Col5a3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O88207
Organism: Mus musculus/domesticus
Length: 1838  
Fragment?: false
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Protein
Q3U962
Organism: Mus musculus/domesticus
Length: 1497  
Fragment?: false
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Protein
Q9JLI2
Organism: Mus musculus/domesticus
Length: 1739  
Fragment?: false
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Publication
9211912 | J:41724
First Author: Malgaretti N
Year: 1997
Journal: J Biol Chem
Title: Mmot1, a new helix-loop-helix transcription factor gene displaying a sharp expression boundary in the embryonic mouse brain.
Volume: 272
Issue: 28
Pages: 17632-9
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Publication
22984613 | J:191757
First Author: Balasubramanian S
Year: 2012
Journal: PLoS One
Title: β3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse.
Volume: 7
Issue: 9
Pages: e45076
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Publication
29436516 | J:273748
First Author: Iskander SM
Year: 2018
Journal: J Am Soc Nephrol
Title: Protein Kinase 2β Is Expressed in Neural Crest-Derived Urinary Pacemaker Cells and Required for Pyeloureteric Contraction.
Volume: 29
Issue: 4
Pages: 1198-1209
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Protein Coding Gene
MGI:88453 | Col3a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88467 | Col1a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88452 | Col2a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96079 | Hgf
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88468 | Col1a2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96969 | Met
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P08121
Organism: Mus musculus/domesticus
Length: 1464  
Fragment?: false
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Protein
Q01149
Organism: Mus musculus/domesticus
Length: 1372  
Fragment?: false
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Protein
Q08048
Organism: Mus musculus/domesticus
Length: 728  
Fragment?: false
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Protein
P28481
Organism: Mus musculus/domesticus
Length: 1487  
Fragment?: false
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Protein
P16056
Organism: Mus musculus/domesticus
Length: 1379  
Fragment?: false
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Protein
P11087
Organism: Mus musculus/domesticus
Length: 1453  
Fragment?: false
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Publication
7543411 | J:28084
First Author: Böttger V
Year: 1995
Journal: Eur J Biochem
Title: Epitope mapping of monoclonal antibodies to keratin 19 using keratin fragments, synthetic peptides and phage peptide libraries.
Volume: 231
Issue: 2
Pages: 475-85
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Publication
17460065 | J:121087
First Author: Bjarnadottir M
Year: 2007
Journal: J Neurosci
Title: Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/- knock-outs compared with wild-type mice.
Volume: 27
Issue: 17
Pages: 4519-29
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Publication
18542050 | J:137676
First Author: Yamamoto S
Year: 2008
Journal: Nat Med
Title: TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration.
Volume: 14
Issue: 7
Pages: 738-47
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Publication
16899073 | J:112589
First Author: Le HT
Year: 2006
Journal: J Neurochem
Title: Reduced NMDA receptor tyrosine phosphorylation in PTPalpha-deficient mouse synaptosomes is accompanied by inhibition of four src family kinases and Pyk2: an upstream role for PTPalpha in NMDA receptor regulation.
Volume: 98
Issue: 6
Pages: 1798-809
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Protein Coding Gene
MGI:95566 | Fn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96610 | Itgb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P09055
Organism: Mus musculus/domesticus
Length: 798  
Fragment?: false
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Protein
P11276
Organism: Mus musculus/domesticus
Length: 2477  
Fragment?: false
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Protein
P34152
Organism: Mus musculus/domesticus
Length: 1052  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom