This entry represents GATOR complex protein WDR24, a component of the GATOR subcomplex GATOR2. GATOR2 is part of the amino acid-sensing branch of the TORC1 signaling pathway, activating mTORC1 by inhibition of the GATOR1 subcomplex. The GATOR2 complex consists of MIOS, SEC13, SEH1L, WDR24 and WDR59 []. WDR24 has a secondary role in the GATOR-independent promotion of lysosome acidity and regulation of autophagic flux [].This entry also includes the restriction of telomere capping protein 1 (Rtc1 or Sea2) from the budding yeast Saccharomyces cerevisiae. It is a component of the SEA complex, termed as GATOR in mammals, which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis [, ].
This entry includes the GATOR complex protein MIOS, a component of the GATOR subcomplex GATOR2. The GATOR2 complex consists of MIOS, SEC13, SEH1L, WDR24 and WDR59, and it activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex [].This entry also includes Sea4 from budding yeasts. Sea4 is a subunit of SEACAT, a subcomplex of the SEA complex. It inhibits the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1-Npr2-Npr3) subcomplex [].
