Thick bands of expression radiated from the hand and along the digit borders. Expression was also visible at presumptive joint sites along the digits, but was not observed in the distal digit tips.
Thick bands of expression radiated from the hand and along the digit borders. Expression was also visible at presumptive joint sites along the digits, but was not observed in the distal digit tips.
Expression was asymmetrical. Expression was clearly restricted to visceral endoderm on one side of the egg cylinder and extended from the distal tip to about half way up the embryonic region.
Expression was evident in the visceral endoderm in a stripe that extends from the embryonic/extraembryonic boundary down toward the distal tip of the embryo. Expression was observed opposite the site of the primitive streak.
Expression was detected in the nuclei of ecto- and mesodermal cells of the visceral endoderm in the area of the primitive streak with the highest intensity being found in the ectodermal cells.
Robust expression remained in the distal extraembryonic visceral endoderm. Once the chorion formed, low-level expression was seen in the proximal extraembryonic visceral endoderm near a developing yolk sac blood island.
Expression was present throughout the length of the vertebral column and somites, marking the caudal half of the forming vertebrae. Expression is confined to perichondrium and osteoblasts; the centers of ossification are negative.
The pattern of labelling does not differ greatly from the previous stage. The number of neurofilament-positive cells or fibers appears increased. Description of the pattern was summarized in Table 2.
Expression in the perichondrium was restricted to the cells directly adjacent to the cartilage. Expression was detected in the bone and in chondrocytes of the hypertrophic zone and the transition zone.
Expression was detected in chondrocytes in the upper hypertrophic zone and in calcified chondrocytes of the lower hypertrophic zone and into the transition zone. Expression was patchy in the proliferative zone. No expression was in the resting zone.
Expression is present in growth plates. It is strongest in the resting zone chondrocytes, whereas it was weaker in the chondrocytes differentiating into the secondary ossification center--the proliferating zone and the hypertrophic zone chondrocytes.
Expression level was unchanged in Atf4-/- growth plates. Authors state that the zone of expression in hypertrophic chondrocytes remained unchanged, or were expanded, if one takes into account the overall length of humeri.
Expression was detected most intensely in the prehypertrophic chondrocytes. Expression was detected in the ostoblasts both in the marrow space and in the bone collar. Smpd3 was not highly expressed in the proliferating zone of the growth plate.
Expressed in multiple clusters aligned in a thick layer under the surface. Expression was roughly similar to that at E17.5, but no expression in in the paramedian rostrodorsal cerebellum.
More cells remained in the cell cycle in mutant (coexpressed with BrdU) than in wild type embryos. Not only the areas around the ventricular zone, but also the inner layer of the cerebellar primodium was labelled by both.
Expression in the external granule cell layer was still detected in the mutant. The Purkinje cell layer expression was largely absent. The posterior region expression was absent in the mutant.
Originally this result was annotated to a female-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Originally this result was annotated to a female-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Expression was detected in all layers of the cortical neuroepithelium, from the ventricular zone to the cortical plate. In interphase cells within the ventricular zone, immunostaining appeared to be symmetrically distributed.
Expression was detected in the intermediate zone of the neocortex in a gradient with highest expression in the lateral borders of the cerebral hemispheres and lower expression near midline.
As in wild type, expression was detected in a broad, dense band with additional scattered cells beneath. However, the dense band is less developed in a large medial region of the cortex with only sparse scattered cells in the mutant.
As in wild type, expression was detected in a broad, dense band with additional scattered cells beneath. However, the dense band is less developed in a large medial region of the cortex with only sparse scattered cells in the mutant.
Expression was detected in the neuroepithelial cell zone. Very low levels of expression were seen in radial processes extending to the ventricular surface. High levels were detected in the upper differentiating zones.
Expression was detected in most regions of the ventricular zone, the cortical plate, layers V/VI and the intermediate zone. Signal in the cortical plate was stronger toward the marginal zone and gradually weakened toward the intermediate zone.
Immunoreactivity in corticofugal fibers was located closer to the pial surface in mutants. The front of staining extended to similar regions of the striatocortical junction and was more widespread as it reached the lateral part of the internal capsule.
Immunoreactivity in corticofugal fibers was located closer to the pial surface in mutants. The front of staining extended to similar regions of the striatocortical junction and was more widespread as it reached the lateral part of the internal capsule.
High expression was detected in progenitor cells of the cortical ventricular zone, at much reduced levels in the subventricular zone, and at intermediate levels in a band of cells in the cortical plate.
Expression was detected in tangentially migrating interneurons in the cortex. No obvious differences in number or laminar distribution of expressing cells within the cortex was seen in the mutant compared to wild type.
Expression was detected in tangentially migrating interneurons in the cortex. No obvious differences in number or laminar distribution of expressing cells within the cortex was seen in the mutant compared to wild type.
Expression was detected in tangentially migrating interneurons in the cortex. No obvious differences in number or laminar distribution of expressing cells within the cortex was seen in the mutant compared to wild type.
Expression was detected in tangentially migrating interneurons in the cortex. No obvious differences in number or laminar distribution of expressing cells within the cortex was seen in the mutant compared to wild type.
Expression was detected in tangentially migrating interneurons in the cortex. No obvious differences in number or laminar distribution of expressing cells within the cortex was seen in the mutant compared to wild type.
Expression was detected in tangentially migrating interneurons in the cortex. No obvious differences in number or laminar distribution of expressing cells within the cortex was seen in the mutant compared to wild type.
Expressed in the cortical interneurons. There was no differences in the number of positive cells in rostral-middle levels. A small but just significant decrease (11%) was observed within the caudal relative to heterozygote littermates.
Expressed in the cortical interneurons. There was a decrease in the total number of labeled cells relative to an animal which was heterozygote for both Robo1 and Robo2 receptors and fully deficient for the Robo3 receptor.
Expression was detected in neurons as they migrated out of the ganglionic eminence and entering the cortex. However, the medial pallium was not reached by the neurons in the mutants.
Coexpression was noted with the pan-neuronal marker Rbfox3. Cux2 was expressed in upper layer neurons as well as in individual neurons distributed in the deep layers of the cortex.
Expression pattern was inverted in the Reeler cortex compared with wild type. The expression pattern indicated that upper layers and deep layers were not only inverted, but also disorganized.
Expression was detected in the radial glia fibers, but there was a severe disruption in the radial glia scaffold, with frequent large gaps between a reduced number of glial fibers.
Highest expression in a layer of relatively large pyramidal neurons. The proportion of strongly positive cells was lower in the adult. Mainly in the cell bodies of neurons, with much fainter staining in the dendrites.
Expression was prominent in the lower half of the cerebral wall. The outer layers are mostly devoid of signal, except for a narrow layer of cells beneath the pia.
Late born interneurons (GFP+/BrdU+) were found mostly in the lower aspect of the cortex. A substantial accumulation of late-born cells was also observed within and below Level I in the cortex.
Expression was detected in an intermediate population of cells between immature progenitors of the cortical hem and mature Cajal-Retzius cells. Many of these cells expressed Dkk3, Sox2, and Reln.
Expression was detected in an intermediate population of cells between immature progenitors of the cortical hem and mature Cajal-Retzius cells. Many cells expressed a mixture of Dkk3, Eomes, and Reln.
Expression was detected in an intermediate population of cells between immature progenitors of the cortical hem and mature Cajal-Retzius cells. Many cells expressed a mixture of Dkk3, Eomes, and Reln.
Expression was detected in an intermediate population of cells between immature progenitors of the cortical hem and mature Cajal-Retzius cells. Many of these cells expressed Dkk3, Sox2, and Reln.
Expression was abnormal in the cortex and showed no obvious decrease on the pallial side of the pallial-subpallial boundary. Expression in subpallium continued across the boundary deep into the lateral cortex where they now overlapped high Pax6 expression.
Expression was detected in perivascular macrophages, identified based on their close proximity to the abluminal side of Pecam1+ endothelial cells between the endothelial and the parenchymal basement membrane (laminin+), the perivascular space.
Expression was detected in the caudal cortex. Labeling weakened after the migrating cells entered the caudal cortex, but continued to be co-localized with Calb1 (56.8% of the Calb1+ cells).
Expression was detected in intermediate progenitor cells (Eomes+) and cells in the transition stage between radial glial cells/intermediate progenitor cells (Eomes+/Pax6+). There was co-localization with Esco2 in both Eomes+ and Eomes+/Pax6+ cells.
Expression was detected in radial glial progenitor cells (Pax6+) and cells in the transition stage between radial glial progenitor cells/intermediate progenitor cells (Eomes+/Pax6+). There was co-localization with Esco2 in both Pax6+ and Eomes+/Pax6+ cells.
Expression was detected in intermediate progenitor cells. In the conditional mutant, expression was lost in the medial and dorsal areas of the cortex and decreased in the lateral area of the cortex.
Expression was also observed in Casp3+ cells that were tdTomato negative, un-recombined cells that would notably include pyramidal cells, CGE-derived cortex inhibitory neurons, and glial cells. No significant difference in the number of Casp3+/tdTomato- cells was observed between genotypes.
Expression was also observed in Casp3+ cells that were tdTomato negative, un-recombined cells that would notably include pyramidal cells, CGE-derived cortex inhibitory neurons, and glial cells. No significant difference in the number of Casp3+/tdTomato- cells was observed between genotypes.
Expression was also observed in Casp3+ cells that were tdTomato negative, un-recombined cells that would notably include pyramidal cells, CGE-derived cortex inhibitory neurons, and glial cells. No significant difference in the number of Casp3+/tdTomato- cells was observed between genotypes.
Fewer immunoreactive granule cells were crossing the molecular layer than at earlier stages. Immunoreactivity was located in the leading elongated process and in some cells in the nascent parallel fibers.
Bergmann glial fibers were strongly labeled throughout the molecular layer. The ascending vertical fibers and subpial terminal feet were most strongly labeled, while labeling of the soma was less conspicuous.
Expressed in GABAergic precursors in the underlying white matter where inhibitory neurons transit after exiting the ventricular zone. Expression was more widespread than Tfap2a, may reflect the expression in non-cerebellar cell types.
Expressed in GABAergic precursors in the underlying white matter where inhibitory neurons transit after exiting the ventricular zone. Expression was more widespread than Tfap2a, may reflect the expression in non-cerebellar cell types.
At E11.5, immunoreactivity was found throughout the lens vesicle as fine granular punctate staining, often in association with Dcp2. Larger cytoplasmic complexes of Tob1 and Dcp2 were observed in posterior vesicle cells.
Expression was detected in all three sizes of ganglion cells, but a significant fraction of each cell type is unstained or lightly stained. The perikaryal cytoplasm and nucleolus are stained.
Cell counting analysis of expressing cells, summarized in Fig 7D. Only the ratio of positive cells in the layer VI was shown, since expression was only seen in the layer VI.
Cell counting analysis of expressing cells, summarized in Fig 7D. Highest expression. Only the ratio of positive cells in the layer VI was shown, since expression was only seen in the layer VI.
Cell counting analysis of expressing cells, summarized in Fig 7D. Decreased expression compared with that of P14. Only the ratio of positive cells in the layer VI was shown, since expression was only seen in the layer VI.
A continuous tract of labelled tissues was seen to extend posteriorly from the base of the thyroid duct to below, and around, the aortic arch. These tissues were tentatively identified as the thryoid and thymus glands.
Smaller clusters of thymic epithelial cells were identified as Krt8+Krt5-, as well as Krt8-Krt5+. Expression of Tbata was detected in both sets of clusters. Additionally, some Tbata+ cells were Krt8+Krt5+.
Smaller clusters of thymic epithelial cells were identified as Krt8+Krt5-, as well as Krt8-Krt5+. Expression of Tbata was detected in both sets of clusters. Additionally, some Tbata+ cells were Krt8+Krt5+.
Expression was exclusively in neural cell bodies; no other cell types were stained. Expression was in many regions of the limbic system: septum nucleus, horizontal & vertical limbs of the Diagonal band, hippocampus, amygdaloid nucleus, & habenula nucleus.
A gradient of expression was noted. Highest levels occurred in the in the newest born cells, and there was a marked decline of expression in mature neurons expressing the marker Rbfox3.
Expression is in cells engaged in mitosis. In early mitosis (prophase, prometaphase) expression was around the chromatin, whereas during anaphase it was at the spindle microtubules. Expression was also in asmall subset of interphase cells localizing predominantly to the nucleoli.
The proximal limit of ventral expression was more distal than the proximal extreme of the En1 expression domain (see assay MGI:5289698). There was no expression in the most distal dorsal ectoderm.
Expression is in the distal limb ectoderm. In all cases (14) expression was first detected in the right limb bud, followed by expression in the same region of the left limb bud.
In the corpus callosum there was a fourfold reduction in the total number of immunopositive cells in the mutant compared to wild type. However, the cell density per unit area was the same as in the wild type.
Individual expressing cells were detected in the migrating staging area over a length of four to five segments. Expression pattern in the tail region was similar to the pattern in Sl/Sl mutants.
Expressed in the median thyroid anlage. The proportion of Nkx2-1-positive cells labelled by BrdU was 13.2% in the mutant (see Fig 7A). But the number of Nkx2-1 positive progenitor cells was significantly lower (see Fig 7B).
Expression was strong in clustered cells at the proximal tubule and was detected in thin walled tubules of the prospective terminal sacs but in hardly any cells compared to wild type.
Expression was strong in clustered cells at the proximal tubule and was detected in thin walled tubules of the prospective terminal sacs but in hardly any cells compared to wild type.
Expression was strong in the proximal core and then extended distally. Expression was tightly associated with the prechondrogenic cell condensations. Expression was mutually exclusive with Sox9 in the perichondrium.
Expression was limited to a domain that encompasses parts of adjacent areas of both the lesser epithelial ridge and greater epithelial ridge. Immunoreactivity was more intense in the lesser epithelial ridge.
Expression was detected in the Telenecephalic Vesicles, dorsal spinal cord and the laterovertebral mesenchyme. The latervertebral mesenchyme is defined as the cells located between the prevertebrae and the dorsal root ganglia.
The boundary of Emx1 expression was largely overlapping with Emx2 expression in the pallial region, but ended more laterally that the Emx2-positive domain, especially evident in the posterior hippocampal region.
The boundary of Emx1 expression was largely overlapping with Emx2 expression in the pallial region, but ended more laterally that the Emx2-positive domain, especially evident in the posterior hippocampal region.
Authors state that the BF-1 (Foxg1)-positive region was normally present, but the negative region was greatly reduced; the border of expression was close to the morphological sulci that delineated the pallium from the roof.
Authors report alterations in expression in the LGE; remains ectopically expressed in LGE occupying more than half of LGE VZ. Stream of Pax6-expressing cells in lateral LGE was severely reduced.
Expression was detected in basal telencephalon including the presumptive region of pallidum and a differentiating field in the posterior rhinencephalon as in wild type. Expression was also detected in a vesicle-like structure in the telencephalic wall.
Expression was absent from the ventricular zone of dorsolateral telencephalic wall and at the border of the cortex and lateral ganglionic eminence. No change of expression was detected in the ventricular zone of medial (hippocampal) telencephalic wall.
Expression was absent from the ventricular zone of dorsolateral telencephalic wall and at the border of the cortex and lateral ganglionic eminence. No change of expression was detected in the ventricular zone of medial (hippocampal) telencephalic wall.
Expression was strong in the periventricular layer and in the cortical plate and was faint in the prefrontal area of the dorsal telencephalon but was absent in the fimbria.
Laterally, only the domain in the telencephalon is noted. Expression was in the lateral and medial ganglionic eminences (LGE,MGE). Caudal boundary between the MGE and caudal ganglionic eminence; rostral boundary between the LGE and cerebral cortex.
Expression was detected in the neuroepithelium of the basal telencephalon. No expression was found in the neuroepithelium of the cortex or hippocampus. Expression was strong in the synthetic zone and weaker in the differentiating zone.
Expression was detected in the neuroepithelium of the basal telencephalon and in the diagonal band of Broca. Expression was strong in the synthetic zone and weaker in the differentiating zone.
Immunopositive fibers extend from the diencephalon toward the ventral surface of the pallidum. The bundle connects the dorsal thalamus and the basal-marginal telencephalon and was not detected in wild type.
Expression was detected in the subventricular rostral migratory stream and in the anlage of central and medial amygdala including the supracapsular and amygdaloid portions of the bed nucleus striae terminalis.
Expression was in the pallial ventricular zone, but was absent from the pallial mantle. Expression extends from the lateral ganglionic eminence to the pial surface in a radial stream.
Expressed across the A-P axis of dorsal telencephalon, with a shallow high to low A-P gradient. Expression was excluded from the increasingly restricted Fgf8 domain in the commissural plate.
Expressed across the A-P axis of dorsal telencephalon, with a shallow high to low A-P gradient. Expression was excluded from the increasingly restricted Fgf8 domain in the commissural plate.
Expression was detected in the neuroepithelium and ventricular zone. Many immunopositive processes extended radially towards the pial surface. In the preplate expression was also found in tangentially orientated processes. Mitotic cells were visible in the intermediate zone.
Expression in glial populations associated with, in particular, the indusium griseum glia, was evident above the corpus callosum from rostral to caudal, and in glial wedge under rostral part of corpus callosum.
Intense labeling was detected in the archicortex at the site of the tela chorioidea attachment. Part of the adjoining hippocampal primordia is negative. Prosomere 6 labeling was found in the olfactory bulb and septal primordia.
Expressed around the ventricle. Expressed in a band of cells a short distance away from the apical surface of the ventricles. In addition, in cortex there was a second band of cells closer to the ventricle.
