Originally this result was annotated to a male-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Originally this result was annotated to a male-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Originally this result was annotated to a male-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Originally this result was annotated to a male-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Originally this result was annotated to a male-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Originally this result was annotated to a male-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Originally this result was annotated to a male-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Originally this result was annotated to a male-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Originally this result was annotated to a male-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Originally this result was annotated to a male-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Originally this result was annotated to a male-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Originally this result was annotated to a male-specific term, but as the specimen was not sexed, it is likely the data annotator intended to use a non-gender specific term.
Expression is in the proliferating cells of the epithelial compartment, including the matrix and precortex. More diffuse staining was detected in the differentiating precursors of the hair shaft cuticle cells.
In the superficial region of the hair follicle, strong expression was detected in the outer root sheath. In the deep region of the hair follicle, expression was markedly reduced in the outer root sheath layer.
Immunostaining was homogeneously distributed on the sarcolemma of both large diameter primary and smaller diameter secondary myotubes, which were in clusters. Expression was also noted at the sites of contact between primary myotubes and myoblasts.
Expression was detected in primary spermatocytes in seminiferous tubules. Tubules at stages V-XI of the spermatogenic cycle express more abundantly than stages I-IV. Signal was not detected in interstitial regions consisting of testicular somatic cells.
Expression was present in the outer layers, where spermatogonia and early spermatocytes are found; it was not found in the inner cell layers where spermatids and sperm are located, nor in the Sertoli cells.
Expression was detected in spermatogonia and Sertoli cells located adjacent to the basement membrane of the seminiferous tubules and in Leydig cells. No differentiating spermatocytes or spermatids hybridized with the probe.
The expression domain was reduced in the mutant, due to the smaller size of the presomitic mesoderm. Expression oscillated normally in the presomitic mesoderm and the posterior nascent (0) somite.
The expression domain was reduced in the mutant, due to the smaller size of the presomitic mesoderm. Expression oscillated normally in the presomitic mesoderm and the posterior nascent (0) somite.
Authors report activation of expression was delayed in epaxial progenitors in the dorsal medial lip of posterior somites. Timing of expression in hypaxial muscle progenitors of ventral lateral lip of myotome is unaffected.
Expression patterns resembled those observed in the wild-type, although it is possible that expression in the hypaxial region of the myotome was slightly stronger. Some embryos had subtle alterations in the shape of the signal in the most rostral somites.
The shape of the somites was perturbed particularly in the inter-limb region correlating to the T1-T13 vertebral elements, which is also the same region of the embryo containing the gonad domain.
Still expressed in a segmented pattern in the mutant somites. Stripes were notably absent from the anterior-most paraxial mesoderm, and were compressed and posteriorly shifted, demonstrating that segmentation proceeded but was delayed.
Still expressed in a segmented pattern in the mutant somites. Stripes were notably absent from the anterior-most paraxial mesoderm, and were compressed and posteriorly shifted, demonstrating that segmentation proceeded but was delayed.
Expression was localized to the apical surface of the segment that is the precursor of the proximal tubule. The layer of cells that will form Bowman's capsule was not labeled.
Expressed in the lateral part of the medial motor column. Only weak immunoreactivity was observed in the medial part of the medial motor column and in the lateral motor column.
The decreased prominence (62%, summarized in Table 1) of the ventromedial columns was partly due to the dispersion of these cells, compared to their clustered arrangement in the heterozygote.
Section in situ hybridization confirmed specific expression in renal corpuscle. Validated anchor gene. Expression was restricted to the more mature Stage IV renal corpuscle. Expression marked the juxtaglomerular arterioles.
Expression was detected in the cilia, which were identified by anti-acetylated tubulin. No GFP fluorescence was observed in nonciliated cells, and no GFP fluorescence was seen in the cytoplasm of ciliated cells.
Expression was detected in several neural crest cell populations, including cells within the wall of the midgut that are enteric nervous system precursors, future spinal ganglia, and future sympathetic ganglia surrounding the aorta.
A sharp decrease in fiber density compared with that of the E13 mutant, but to a level which was still significantly higher than that of the wild-type male (quantified in Fig 5B).
At the interlimb level of the trunk, there was strong expression in the intercalated myotome but faint expression in the ventrolateral (hypaxial) portion of the myotome compared to Myogenin staining the whole myotome.
Expressed in the epithelial component of the juxta-oral organ. The distribution of the anterior and middle portions from mandible to orbit was the same in heterozygous and homozygous animals. Staining was generally more intense in the homozygous animals.
Expression was detected in the dental epithelium. Dmrt2-expressing cells in the posterior region delineate Irx1 staining in the dental lamina posteriorly. The anterior boundary was delineated with Cxcl14 expression.
The expression domain in the posterior hindbrain ventricular zone corresponds to the domain of neuroepithelium from which En1 expressing cells derive. The rostral limit of the ventral expression was at the rhombomere 1-2 border.
Expression extended over the caudal two thirds of the midbrain. Expression was not throughout the thickness of the neuroepithelium, but in single neuroblasts on the pial surface of the midbrain.
Intense staining was detected in trophoblast giant cells emerging around the embryo and penetrating the uterine surface epithelium at points of implantation. Also, smaller trophoblast cells in contact with the uterine surface gave signal.
Expression was in the junctional zone where positive cells were primarily clustered around maternal blood sinuses. Some smaller cells in this region also were positive, which be spongiotrophoblasts that have begun to differentiate into giant cells.
Twenty-four hours after BrdU pulse, the fraction of BrdU+ hem cells that were Mki67- (i.e. cells that exited the cell cycle within the 24-hour period) was decreased at E15.5.
Twenty-four hours after BrdU pulse, the fraction of BrdU+ hem cells that were Mki67- (i.e. cells that exited the cell cycle within the 24-hour period) was decreased at E15.5.
Expression was detected in the cortical hem, but only increased modestly compared to E14.5. Expression did not reach the same level as control, except for a few cells at the dorsal edge of the hem.
Moderate expression was detected in cells forming the external capsule of the Pacinian corpuscles. No expression was in the central axon or among the layers of the inner core of the corpuscle.
Expressed mainly on the oral side with extension to the oral portion of the medial edge epithelium region. Expressed only in the periderm layer, whereas the basal layer was negative.
Expression is present in the caecum. The distal half was uniformly stained. In the proximal part (up to the junction with the small intestine), the staining was restricted to the outer curvature.
Expression was diffuse, greatly reduced and cytoplasmic in the entire villus as compared to wild type. The wild type apical staining pattern was still visible in the crypt cells.
A smaller, but significant reduction in the immunopositive cortical inhibitory neuron population was observed, in agreement with the notion that a subpopulation of Reln+ cells is born in the medial ganglionic eminence.
Cell counting analysis of expressing cells, summarized in Fig 7D. Highest expression. Only the ratio of positive cells in the layer VI was shown, since expression was only seen in the layer VI.
Cell counting analysis of expressing cells, summarized in Fig 7D. Decreased expression compared with that of P14. Only the ratio of positive cells in the layer VI was shown, since expression was only seen in the layer VI.
Higher expression in Six2+ nephron progenitor cells on the peripheral side of the branching ureteric bud, but its expression was downregulated in the differentiating progenitors migrating to the ventral side.
Higher expression in Six2+ nephron progenitor cells on the peripheral side of the branching ureteric bud, but its expression was downregulated in the differentiating progenitors migrating to the ventral side.
The ventral-most parts of the tongue and epithelium overlying the tongue were not labelled. There was a sharp boundary at the anatomical boundary between the body and root of the tongue between labelled anterior and non-labelled posterior parts.
Expression is present in the dorsal lingual epithelium containing the filiform papillae, the stratum granulosum, and the stratum germinativum; the connective tissue between the striated muscle and the stratum germinativum was not immunoreactive.
A heterogeneous expression pattern was noted in the mutant cusps. In areas with reduced staining, mesenchymal cells were aligned parallel to each other but independently of other regions of the cusp.
A heterogeneous expression pattern was noted in the mutant cusps. In areas with reduced staining, mesenchymal cells were aligned parallel to each other but independently of other regions of the cusp.
Reduced expression in both the proximal and distal duodenum, compared with the wild type. Expression was uniform when no atresia formed. Expression was restricted to the mesenteric side. Little or no expression within the antimesenteric mesoderm.
A gradient of expression was noted. Highest levels occurred in the in the newest born cells, and there was a marked decline of expression in mature neurons expressing the marker Rbfox3.
Expression was unchanged in the dorsal subventricular zone and mantle zone. Expression was moderately/mildly decreased in the ventral subventricular zone and mantle zone. It was undetectable in the ventricular zone.
Expression was detected throughout the urogenital ridge in the gonadal part and the mesonephric part with the exception of the epithelium of the mesonephric tubules and the Wolffian duct.
Wnt10b is expressed at the mesial tip of the jaw in a short, thin strip of epithelial cells that extends distally. In all cases, expression was symmetrical on either side of the median sulcus.
Bmp2 is expressed at the mesial tip of the jaw in a short, thin strip of epithelial cells that extends distally. In all cases, expression was symmetrical on either side of the median sulcus.
Prior to contact of the shelves, expression was in a broad domain of the mid-posterior palatal epithelium. Expression was detected along the medial aspect of the approaching shelves with strongest expression in the posterior half of the palate.
Expression was particularly concentrated in epithelial cells of the region of palatal outgrowth. In some sections the mRNA was more abundant in oral epithelium than elsewhere in the palate.
Expression was strongly nuclear with cytoplasmic staining also observed in epithelia. Expression was throughout the tissues with no apparent regionalization, and there appeared to be few cells without immunostaining. Immunostaining was significantly higher in epithelium compared to mesenchyme.
Expression was detected in periderm cells at the palate fusion point. The periderm cells were concentrated in the epithelial triangles, with occasional remaining cells in the medial epithelial seam.
Expression was greatly reduced in double mutants, particularly in the region caudal to the sulcus telodiencephalicus. Caudal limit shifted rostrally and expression was restricted to the more dorsal region.
From the region near the otocyst a rod of expressing cells was seen, running down from the otic region parallel to the branchial artery towards the distal tip of the second arch.
Present in the outer retina, including the peripheral margin, in a graded fashion, with higher expression in the dorsal retina compared to the ventral retina. There was no expression in the retinal ganglion cell layer.
Present in the outer retina, including the peripheral margin, in a graded fashion, with higher expression in the dorsal retina compared to the ventral retina. There was no expression in the retinal ganglion cell layer.
Expression was detected in the inner neuroblastic layer and a subset of cells in the outer neuroblastic layer. The expression level was higher in the subset of cells in the outer neuroblastic layer.
Expression was detected in the scleral inner neuroblastic layer and a subset of cells in the scleral outer neuroblastic layer. The expression level was higher in the scleral inner neuroblastic layer.
Expression was detected in the inner neuroblastic layer and a subset of cells in the scleral outer neuroblastic layer. The expression level was higher in the inner neuroblastic layer.
Expression was detected in a subset of cells in the outer neuroblastic layer and in the scleral inner neuroblastic layer. The expression level was higher in the scleral inner neuroblastic layer.
Expression was detected in a subset of cells in the outer neuroblastic layer and in the scleral inner neuroblastic layer. The expression level was higher in the scleral inner neuroblastic layer.
Expression was detected in dividing progenitor cells in the outer neuroblast layer of the retina. Much lower levels were noted in postmitotic precursors and differentiated cells in the inner neuroblast layer.
Expression was detected in dividing progenitor cells in the outer neuroblast layer of the retina. Expression was excluded from postmitotic precursors and differentiated cells in the inner neuroblast layer.
Expression was detected in dividing progenitor cells in the outer neuroblast layer of the retina. Much lower levels were noted in postmitotic precursors and differentiated cells in the inner neuroblast layer.
Elevated expression was detected in photoreceptor precursors in the presumptive outer nuclear layer, retinal progenitor cells in the outer neuroblastic layer, and differentiating cells in the inner neuroblastic layer in a salt and pepper-like pattern.
Expression was detected in a small number of presumptive photoreceptor cells scattered throughout the upper presumptive outer nuclear layer and in retinal progenitor cells in the outer neuroblastic layer.
At the outer edge of the outer nuclear layer, cell bodies expressing significant levels of DCC protein were distributed sparsely. Overall, the level of DCC protein detected in the E15.5 outer nuclear layer was low.
Expression was detected in a transverse horizontal domain in the mutant, instead of the 2 lateral ones on the right and left hindlimb buds seen in the wild type.
Fgf5 mRNA levels were relatively high throughout the streak, with differential expression along the proximodistal axis; signal intensity in the most proximal region was 2- to 3-fold lower than in the most distal region.
In the half the mutants, expression was expanded relative to that seen in wild type but was still localized at its normal position at the distal tip of the primitive streak.
Expression was detected in ectoderm and mesoderm of the primitive streak. The expression domain spread to reach the anterior part of the primitive streak. The rostral extremity of expression was further anterior in the ectoderm than in the mesoderm.
Expression was detected within and along the posterior part of the primitive streak in ectoderm and mesoderm. The rostral boundary of expression was more posterior in the mesoderm than in the ectoderm.
Wnt4 signal was strongest at the junction where it contacts the ovary and two lines of signal in the mesonephric mesenchyme running medial to and parallel to the nephric duct and paramesonephric duct.
Expression is present throughout the prosomere 2 ventricular zone, with expression extending into a region of the postmitotic mantle zone. It was not present in the Rim/pTh-R/Zli-shell or the Zli.
Expression is present throughout the prosomere 2 ventricular zone, with expression extending into a region of the postmitotic mantle zone. It was not present in the Rim/pTh-R/Zli-shell or the Zli.
Expression is present throughout the prosomere 2 ventricular zone, with expression extending into a region of the postmitotic mantle zone. It was not present in the Rim/pTh-R/Zli-shell or the Zli.
Expression is present throughout the prosomere 2 ventricular zone, with expression extending into a region of the postmitotic mantle zone. It was not present in the Rim/pTh-R/Zli-shell or the Zli.
Expression is present throughout the prosomere 2 ventricular zone, with expression extending into a region of the postmitotic mantle zone. It was not present in the Rim/pTh-R/Zli-shell or the Zli.
In the mutant smooth muscle differentiation was severely deficient; some was seen in 5 of 10 right arches and 5 of 10 left arches. It was located in the posterior aspect of the vessel.
Expressed in all cells in a pattern that comprises a combination of cytoplasmic, perinuclear and nuclear localization. Nuclear staining was apparent, but weaker as compared to stronger staining in the cytoplasm.
Expressed in all cells in a pattern that comprises a combination of cytoplasmic, perinuclear and nuclear localization. Nuclear staining was apparent, but weaker as compared to stronger staining in the cytoplasm.
Expression was in dispersed cells, continuous with the positive staining in the lateral ganglionic eminence and olfactory bulb. Staining in the cerebral cortex was only a fraction of the staining in the subventricular zone of the ganglionic eminence.
Expressed in the cortical interneurons. There was a significant reduction in the number of positive cells compared with heterozygote littermates in rostral-middle levels and caudal levels of the cortex.
Expression was detected in horizontally orientated cells at the outer edge of the marginal zone. This was a distinct population from the Gad1-labeled cells localized at the inner edge of the marginal zone.
Expression was detected at the inner edge of the marginal layer. The Gad1-positive cells were a distinct population from the Rcan2-positive cells at the outer edge of the marginal zone.
At E16.5, there was no difference in the distribution of immunopositive cells between control and mutant mice, and the total number of labeled neurons was similar in the two genotypes.
At E16.5, there was no difference in the distribution of immunopositive cells between control and mutant mice, and the total number of labeled neurons was similar in the two genotypes.
