With increasing loss of Sox9 dosage on the Pdx1 null background, dorsal and ventral pancreatic buds become increasingly hypoplastic and not discernable.
With increasing loss of Sox9 dosage on the Pdx1 null background, dorsal and ventral pancreatic buds become increasingly hypoplastic and not discernable.
With increasing loss of Sox9 dosage on the Pdx1 null background, dorsal and ventral pancreatic buds become increasingly hypoplastic and not discernable.
With increasing loss of Sox9 dosage on the Pdx1 null background, dorsal and ventral pancreatic buds become increasingly hypoplastic and not discernable.
With increasing loss of Sox9 dosage on the Pdx1 null background, dorsal and ventral pancreatic buds become increasingly hypoplastic and not discernable.
With increasing loss of Sox9 dosage on the Pdx1 null background, dorsal and ventral pancreatic buds become increasingly hypoplastic and not discernable.
Co-expressed with Sox9 only in the paired ventral condensations of the presternum. None of these presternum elements showed contribution from Meox1-Cre labelled somite derived cells.
Co-expressed with Sox9 only in the paired ventral condensations of the presternum. None of these presternum elements showed contribution from Meox1-Cre labelled somite derived cells.
Amh-positive cells were found co-expressing Sox9 at the border between testis cords and the rete testis at E16.5. These cells were also found to express Pax8.
Co-expressed with Sox9 within the intercostoclavicular mesenchyme at the lateral edges of the ventral sternum, with the Hoxa5 domain extending more broadly ventral to Sox9.
Co-expressed with Sox9 within the intercostoclavicular mesenchyme of the ventral sternum, with the Hoxa5 domain extending more broadly ventral to Sox9.
Expressed in a lateral domain that was Sox9 negative and throughout the region of rib 1 attachment, although appear continuous with the Sox9 positive domain.
Expressed in a lateral domain that was Sox9 negative and throughout the region of rib 1 attachment, although appear continuous with the Sox9 positive domain.
Partial sex reversal, with ectopic expression in the mutant. SOX9 and FOXL2 expression was not segregated spatially, the proteins were not expressed in the same cell.
Expression was restricted to the pre-pancreatic domain. The Sox2-positive domain, from which the stomach develops, formed a boundary with both the Pdx1+ and Sox9+ domains. Very few cells co-expressing Sox2, Pdx1, and Sox9 were observed at this boundary.
Expression was strong in the proximal core and then extended distally. Expression was tightly associated with the prechondrogenic cell condensations. Expression was mutually exclusive with Sox9 in the perichondrium.
The Sox2-positive domain, from which the stomach develops, formed a boundary with both the Pdx1+ and Sox9+ domains. Very few cells co-expressing Sox2, Pdx1, and Sox9 were observed at this boundary.
Co-expressed with Sox9 within the intercostoclavicular mesenchyme at the lateral edges of the ventral presternum, with the Hoxa5+ only domain extending more broadly ventral to Sox9. None of these presternum elements showed contribution from Meox1-Cre labelled somite derived cells.
Co-expressed with Sox9 within the intercostoclavicular mesenchyme at the lateral edges of the ventral presternum, with the Hoxa5+ only domain extending more broadly ventral to Sox9. None of these presternum elements showed contribution from Meox1-Cre labelled somite derived cells.
Co-expressed with Sox9 within the intercostoclavicular mesenchyme at the lateral edges of the ventral presternum, with the Hoxa5 domain extending more broadly ventral to Sox9. None of these presternum elements showed contribution from Meox1-Cre labelled somite derived cells.
Co-expressed with Sox9 in the presternum. Rib 1 appeared to make contact with the rounded, medial region. Sternal bar fusion was also incomplete. None of these presternum elements showed contribution from Meox1-Cre labelled somite derived cells.
Co-expressed with Sox9 in the presternum. Rib 1 appeared to make contact with the rounded, medial region. Sternal bar fusion was also incomplete. None of these presternum elements showed contribution from Meox1-Cre labelled somite derived cells.
Co-expressed with Sox9 in the presternum. Rib 1 appeared to make contact with the rounded, medial region. Sternal bar fusion was also incomplete. None of these presternum elements showed contribution from Meox1-Cre labelled somite derived cells.
Expressed in the ventral elements, but remained excluded from the dorsal elements. expression is excluded from the most medial cells of the ventral elements, but overlapped with Sox9 in the lateral part of these condensations.
Expressed in the ventral elements, but remained excluded from the dorsal elements. expression is excluded from the most medial cells of the ventral elements, but overlapped with Sox9 in the lateral part of these condensations.
Expressed in the ventral elements, but remained excluded from the dorsal elements. expression is excluded from the most medial cells of the ventral elements, but overlapped with Sox9 in the lateral part of these condensations.
Over 90% of the hair follicles were unpolarized and displayed vertically-oriented growth. The Cdh3 staining was observed as a central cluster of immunostained cells surrounded by Sox9 immunostaining (described as a bicycle wheel like ring of staining). Few follicles displayed asymmetry and were oriented randomly.
