This domain is found in the human ATP-binding cassette sub-family F member 3 (ABCF3) and related proteins. ABCF3 enhances OAS1B-mediated flavivirus resistance by localising to the virus-remodelled endoplasmic reticulum and reducing viral RNA synthesis [, ]. In humans, ABCF3 promotes cell proliferation through interactions with tumour protein D52 family members. The domain represented by this entry, located at the N-terminal has detectable similarity to known PWI domains, and it is predicted to adopt a similar structure composed of four ��-helical up-and-down bundle.
