ADAMDEC1 peptidase (also known as decysin; MEROPS identifier M12.219) unusually for an ADAM peptidase lacks the disintegrin and ADAM-CR domains []. It is the only ADAM metallopeptidase in which the third zinc ligand is an aspartic acid rather than a histidine []. It is synthesized as a precursor and activated by furin []. The active enzyme has limited specificity for Leu in P1' []. ADAMDEC1 was initially thought to be involved in the immune response, because it was found in mature spleen follicular dendritic cells and germinal centres [], but it is also found in uterine stromal cells []and transcripts are highly expressed in pulmonary sarcoidosis [].
