Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2), also known as multisynthase complex auxiliary component p38, is required for assembly and stability of the multi-tRNA synthetase complex (MSC complex) []. MSC is a macromolecular protein complex consisting of nine different ARSs and three ARS-interacting multifunctional proteins (AIMPs) [].
This entry represents the lysyl-tRNA synthetase (LysRS) binding domain of AIMP2 (aminoacyl tRNA synthase complex-interacting multifunctional protein 2). LysRS can serve as a transcription regulator that can be released from the cytoplasmic multi-tRNA synthetase complex (MSC) to activate the transcription factor MITF in stimulated mast cells. In quiescent cells, LysRS is held in the MSC via its interactions with AIMP2 [].
This is a thioredoxin like domain found in AIMP2 proteins (aminoacyl tRNA synthetase complex interacting multifunctional protein 2). AIMP2 is a component of human multi-tRNA synthetase complex (MSC). MSC is a macromolecular protein complex consisting of nine different ARSs and three ARS-interacting multifunctional proteins (AIMPs) [].
