AMIGO-1 was identified as a protein induced in neurons by the neurite-promoting protein amphoterin. It is highly expressed in the nervous system. AMIGO-1 has a role in regulating dendritic growth and neuronal survival []. It is involved in fasciculation and myelination of developing neural axons, as well as in regeneration and plasticity of the adult fibre tracts []. It displays a homophilic and heterophilic binding mechanism, which suggest a role as a cell adhesion molecule []. AMIGO acts as a function-modulating auxiliary subunit for potassium channel alpha-subunit Kv2.1, which is highly expressed in the brain [].
