This entry represents the type I KH domain of ANKHD1 and similar animal proteins.ANKHD1, also called HIV-1 Vpr-binding ankyrin repeat protein, or multiple ankyrin repeats single KH domain, or Hmask, is highly expressed in various cancer tissues and is involved in cancer progression, including proliferation and invasion [, , , , , ]. It acts as a scaffolding protein that may be associated with the abnormal phenotype of leukaemia cells. It may play a role in multiple myeloma cell proliferation and cell cycle progression by regulating expression of p21 [, , ]. ANKHD1 is a component of Hippo signalling pathway. It functions as a positive regulator of YAP1 and promotes cell growth and cell cycle progression through Cyclin A upregulation in prostate cancer cells [].
