ANKS4B (also known as Harp) is part of the intermicrovillar adhesion complex (IMAC) and plays a role in epithelial brush border differentiation, controlling microvilli organization and length. It interacts with USH1C and MYO7B, which link protocadherins to the actin cytoskeleton []. In mouse epithelial tissues, HARP interacts with the PDZ domain of harmonin. This scaffolding complex facilitates signal transduction in epithelia []. ANKS4B has an N-terminal ankyrin repeat region and C-terminal SAM. This entry represents the SAM domain, which is a protein-protein interaction domain.
