AP-3 complex subunit delta-1 (AP3D1) is part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. AP3D1 is required for efficient transport of VSV-G (vesicular stomatitis virus glycoprotein) from the trans-Golgi network to the cell surface [].This entry represents the AP-3 complex subunit delta domain found in metazoa.
The adaptor protein complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 3 (AP-3) appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. AP-3 is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). The subunits of non-clathrin- and clathrin-associated adaptor protein complex 3 play a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or in endosomes. This group represents an adaptor protein complex AP-3, delta subunit.
