Amyloid beta A4 precursor protein-binding family A member 3, also known as Mint3, X11gamma, or X11L2, is a adaptor protein that enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of FIH-1 (factor inhibiting HIF-1). It may be a potential therapeutic target to regulate macrophage-mediated inflammation []. X11gamma regulates the traffic of the Alzheimer's precursor protein (APP) from the trans-Golgi network [].The X11/Mint family members are multidomain proteins typically composed of a conserved PTB domain and two C-terminal PDZ domains. They are adaptor proteins that possess several functions, such as trafficking and transport, synaptic function and regulation of ion channel []. Two of the family members, X11alpha and X11beta, are expressed primarily in neurones [].
