ARHGEF37 (Rho guanine nucleotide exchange factor 37) contains a RhoGEF [or Dbl homology (DH)]domain followed by a Bin/Amphiphysin/Rvs (BAR) domain, and two C-terminal SH3 domains. Its specific function is unknown. This entry represents the second SH3 domain of ARHGEF37.
ARHGEF37 contains a RhoGEF (or Dbl homology, DH) domain followed by a Bin/Amphiphysin/Rvs (BAR) domain, and two C-terminal SH3 domains. Its specific function is unknown. Its domain architecture is similar to the C-terminal half of DNMBP or Tuba, a cdc42-specific GEF that provides a functional link between dynamin, Rho GTPase signaling, and actin dynamics, and plays an important role in regulating cell junction configuration. GEFsactivate small GTPases by exchanging bound GDP for free GTP [].This entry represents the firs C-terminal SH3 domain of ARHGEF37.
