AT-rich interactive domain-containing protein 1B (ARID1B or BAF250b) is part of the SWI/SNF-like ATP-dependent chromatin remodelling complex that regulates gene expression through regulating nucleosome remodelling [, ]. In humans there are two BAF250 isoforms, BAF250a/ARID1A and BAF250b/ARID1B []. Both BAF250a and BAF250b bind DNA non-specifically []. BAF250b is also a component of the BAF [], SWI/SNF-like EBAFb [], npBAF and nBAF complexes [], which remodel chromatin. ARID1B exhibits tumour-suppressor activities in pancreatic cancer cell lines [, [cite:]]. Mutations in the ARID1B gene cause Coffin-Siris syndrome, exhibiting developmental defects, and haplo-insufficiency of ARID1B, a frequent cause of intellectual disability [, ]. Moreover, mutations in the ARID1B gene have been found in many cancers [].This entry represents the ARID/BRIGHT DNA binding domain of ARI1B. It binds DNA in a non-sequence-specific manner similar to ARID1A [].
