ARID5B, also known as modulator recognition factor-2 (Mrf-2), is a member of the AT-rich interaction domain (ARID) family of transcription factors []. Human ARID5B forms complex with PHF2, a jmjC demethylase; this complex serves as a signal-sensing modulator of histone methylation and gene transcription []. It facilitates chondrogenesis by recruiting the histone demethylase PHF2 to Sox9-regulated genes []. Mouse Mrf-2 is required for adipogenesis and to maintain normal functions in mature adipocytes []. The genetic variations in the ARID5B gene have been linked to susceptibility to type 2 diabetes [], acute lymphoblastic leukemia[]and coronary atherosclerosis [].
