The Arp2/3 complex binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures [].The human Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. This entry represents actin-related protein 2/3 complex subunit 1A (ARC1A) from vertebrates. ARC1A shares protein sequence similarity with ARPC1B and is predicted to function as ARPC1B in the Arp2/3 complex.
