This family represents Arylsulfatase B (ARSB) and its paralogues, ARSI and ARSJ. ARSB removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation [, ]. It is involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium []. ARSI displays arylsulfatase activity at neutral pH, when co-expressed with SUMF1. Arylsulfatase activity has been detected in the secretion medium of retinal cell line, but no activity has been recorded when measured in cell extracts [, ].
This entry includes Trivalent organoarsenical cleaving enzyme from Thermomonospora curvata (ArsI), Cadmium-induced protein CadI from Mycobacterium tuberculosis, and related bacterial proteins. ArsI is a nonhaeme iron-dependent dioxygenase that can break carbon-arsenic bonds, playing a role in the detoxification of environmental organoarsenical compounds. It catalyses the oxygen-dependent demethylation of highly toxic methylarsonous acid (MAs(III)) to arsenite, which can then be exported out of the cell [, ]. Proteins in this entry contain a VOC (Vicinal Oxygen Chelate) domain (). Members of this family have an invariant CC sequence motif at about position 95, and have poorly conserved C-terminal regions that frequently contain at least one addition CC motif [].
