The Arf GAPs (GTPase-activating proteins) are a family of multidomain proteins with the common function of accelerating the hydrolysis of GTP bound to Arf proteins. ASAP proteins are a subtype of Arf GAPs. ASAP3 (Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3), also known as DDEFL1 (development and differentiation-enhancing factor-like 1) or ACAP4, is a focal adhesion-associated Arf GAP that functions in cell migration and invasion of cancers [, ]. ASAP3 promotes cell proliferation [].
