This entry represents activating signal cointegrator 1 complex subunit 1 (ASCC1, or ASC-1 complex subunit p50). In humans ASSC1 is part of the ASC-1 complex, consists of ASC-1, P200, P100, and P50. ASC-1 complex serves as a transcription coactivator molecule of nuclear receptors []. Human ASC-1 complex seems to play an essential role in AP-1, SRF, and NF-kappaB transactivation [].This entry also include some uncharacterised proteins from fungi (such as C15D4.13c from S. pombe).
This entry represents the CUE domain found in ASCC2 and related proteins. ASCC2 (also known as ASC-1), together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo [, ].
