This entry includes [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]]kinase (BCKDK) and [Pyruvate dehydrogenase (acetyl-transferring)]kinase (PDK). BCKDK catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways [].Pyruvatedehydrogenase kinase inhibits the pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism [].
