Filensin (also known as BFSP1) is a lens-specific cytoskeletal protein that interacts with aquaporin-0 (AQP0). It plays an important role during lens development []. Mutations of the Filensin gene cause Cataract 33, multiple types (CTRCT33), an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness [].