CDO (Cell Adhesion Molecule-Related/Down Regulated by Oncogenesis) and brother of CDO (BOC) are members of the Ig superfamily. They are components of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and promotes differentiation of myogenic cells []. Both CDO and BOC are also targets and signalling components of the Sonic hedgehog (Shh) pathway [].BOC has four Ig-like loops, three fibronectin type III (FNIII) repeats, a single transmembrane span, and an intracellular domain []. It has been identified as an axon-guidance molecule [, ].
CDO (Cell Adhesion Molecule-Related/Down Regulated by Oncogenesis) and brother of CDO (BOC) are members of the Ig superfamily. They are components of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and promotes differentiation of myogenic cells []. Both CDO and BOC are also targets and signalling components of the Sonic hedgehog (Shh) pathway [].CDO is a transmembrane glycoprotein with five Ig-like loops, three FNIII repeats, a single transmembrane span, and an intracellular domain [, ]. CDO has been shown to promote neuronal differentiation [, ].
