Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins. The BET proteins contain two bromodomains and a region of homology in the C-terminal region, designated the extra terminal (ET) motif. The first bromodomain in Brdt has been shown to be essential for male germ cell differentiation []. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [].This entry represents the second bromodomain found in Brdt and related proteins.
Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins. The BET proteins contain two bromodomains and a region of homology in the C-terminal region, designated the extra terminal (ET) motif. The first bromodomain in Brdt has been shown to be essential for male germ cell differentiation []. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [].This entry represents the first bromodomain found in Brdt and related proteins.