The CD1 family of proteins includes exosome-associated cofactor Rrp47, and DNA double-strand repair protein C1D. Both of these proteins are implicated in DNA double-strand repair and in nuclear exosome activity.Rrp47 functions in nuclear RNA processing. Rrp47 is associated with nuclear exosomes, and with the nuclear exosome-specific 3'-5' exonuclease Rrp6.Rrp47 appears to be a substrate-specific nuclear cofactor that is required for the 3' processing of pre-rRNAs, snoRNAs and snRNAs (specifically U4 and U5) []. However, Rrp47 is not required for cytoplasmic exosome mRNA degradation. It also appears to have a role in DNA strand repair.C1D is an inducible nuclear matrix proteins that interacts with and activates the DNA-dependent protein kinase essential for DNA double-strand repair and V(D)J recombination []. C1D can interact with condensin, which is required for DNA repair and replication checkpoint control []. C1D also binds to nuclear exosomes and might regulate their functional activities, as it has RNA-binding activity [].
This entry represents Something about silencing protein 10 (SAS10, also known as UTP3)and U3 small nucleolar ribonucleoprotein protein LCP5 which are components of the U3 ribonucleoprotein complex []. It also includes Nuclear nucleic acid-binding protein C1D from Mus musculus (Mouse), which plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA [], Protein THALLO from Arabidopsis thaliana, essential during embryogenesis [, ]and the human protein Neuroguidin, an initiation factor 4E (eIF4E)-binding protein [].
