This entry represents a middle domain found in proteins of the calcium channel subunit alpha-2/delta family in vertebrates. This includes CACHD1 (VWFA and cache domain-containing protein 1). These are single-pass type I membrane proteins that regulate voltage-dependent calcium channels. CACHD1 contains a VWFA domain () and two Cache domains. Cache domains are extracellular sensory domains that typically bind small ligands. CACHD1 interacts with Wnt receptors and regulates neuronal asymmetry in zebrafish brain development []. This domain contains a CACHE-like fold.
This entry represents a Cache domain found centrally in proteins of the calcium channel subunit alpha-2/delta family mainly in vertebrates. This includes CACHD1 (VWFA and cache domain-containing protein 1) and CACNA2D (voltage-dependent calcium channel subunit alpha-2/delta) proteins. These are single-pass type I membrane proteins that regulate voltage-dependent calcium channels. CACHD1 contains a VWFA domain () and two Cache domains, while CACNA2D proteins contain a VWFA domain and one Cache domain []. Cache domains are extracellular sensory domains that typically bind small ligands. CACHD1 interacts with Wnt receptors and regulates neuronal asymmetry in zebrafish brain development []. The specific ligand-binding properties of this domain remain to be determined.
This entry represents the C-terminal domain of VWFA and cache domain-containing protein 1 (CACHD1). CACHD1 is a single-pass type I membrane protein that may regulate voltage-dependent calcium channels. The protein belongs to the calcium channel subunit alpha-2/delta family and is found in animals []. CACHD1 contains an N-terminal signal peptide. The specific function of this C-terminal domain remains to be determined. This domain is followed by a large disordered region.
