This entry represents leucine-rich repeat-containing protein 16C, also known as F-actin-uncapping protein RLTPR or CARMIL2 in humans. It belongs to the CARMIL (capping protein, Arp2/3 and Myosin-I linker) family. CARMIL family members are potential regulators of actin capping proteins, which control the polymerisation of actin filaments by capping their barbed ends []. CARMIL2 associates with vimentin intermediate filaments and controls cell polarity []. It is necessary for cell migration, lamellipodial assembly, membrane ruffling and macropinocytosis [, ].
