This entry represents a coiled coil domain in the coiled-coil domain-containing protein 110 (CCDC110) family. CCDC110 is a nuclear protein that contains an extended coiled-coil domain spanning approximately 350 residues in the C-terminal region. The protein is expressed specifically in testis and is also found in tumours of different origins. CCDC110 has been identified as a cancer/testis antigen (CT52 or KM-HN-1) that can be recognised by both cellular and humoral immune responses []. The protein undergoes alternative splicing to produce multiple isoforms. While CCDC110 localises to the nucleus, the specific function of this protein remains to be determined.
