Macrophage-derived chemokine or CC chemokine 22 (MDC/CCL22) is a chemokine produced by macrophages and dendritic cells []. It is a chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells []. It binds to receptor CCR4 [, ]. MDC/CCL2 may play an important role in the recruitment of TH2 cells into the inflammatory sites and the regulation of T helper type 2 (TH2)-related immune responses [, ].
