Cyclin-dependent kinase inhibitor 1B (CDKN1B, also known as p27Kip1) controls cell proliferation by binding to and regulating the activity of cyclin-dependent kinases (Cdks) []. It is also involved in cell migration through binding and regulation of RhoA or stathmin [, , ]. It also inhibits DNA replication by binding to the DNA replication licensing factor MCM7 [].
This entry represents the zinc-ribbon domain found in RCHY1 and related proteins. RCHY1, also known as Pirh2, is a ubiquitin E3 ligase that mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B [, ].
