Centrosomal protein of 152kDa (Cep152) acts as a scaffold for recruitment of centriole regulators, Plk4 and CPAP, to the centrosome [, ]. In multiciliated cell (MCCs), the basal bodies of the motile cilia are derived from centroles, which are amplified in a structure known as the deuterostome. Cep152 is required for the centriole biogenesis in deuterostome [].
Centriole amplification is controlled by two duplicated genes, Cep63 (centrosomal protein of 63kDa) and Deup1 (Deuterosome assembly protein 1).Cep63 regulates mother-centriole-dependent centriole duplication, whereas Deup1 is involved in large-scale de novo centriole biogenesis. Deup1, previously known as coiled-coil domain-containing protein 67, is a structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deup1 binds to Cep152 and then recruits Plk4 to activate centriole biogenesis [].
